Controlled delivery of the popular nonsteroidal anti-inflammatory drug, paracetamol, from chitosan-g-polyacrylamide microspheres prepared by the emulsion crosslinking technique

Abstract

In this paper, chitosan-graft-polyacrylamide (CS-g-PAAm) microspheres as drug delivery matrices of paracetamol were prepared by the emulsion crosslinking technique, using glutaraldehyde (GA) as a crosslinker. Graft copolymer of chitosan with acrylamide was synthesized using cerium (IV) ammonium nitrate (CAN). The microspheres formed had average particle sizes in the range of 78-252 μm. Paracetamol entrapment efficiency was found to vary between 31.89% and 72.61%, as determined by UV spectroscopy. Drug release in acidic and phosphate buffer solutions (pH 1.2 and 7.4) of the CS-g-PAAm microspheres was influenced by formulation factors such as the concentration of CS-g-PAAm, the paracetamol/polymer ratio (w/w), and the amount of crosslinker.

Chitosan-N-acetyl cysteine microspheres for ocular delivery of acyclovir: Synthesis and in vitro/in vivo evaluation

“…Emulsions were Lviv Polytechnic National University Institutional Repository http://ena.lp.edu.ua formulated based on different operating conditions of time and stirring speed, indicating that the emulsion systems were non-irritant with self-preserving properties and that they can be used as a template for the production of pharmaceutical and cosmetics vehicles intended for topical administration purposes [247]. E. Bulut [248] has also employed an emulsion crosslinking technique to obtain microspheres based on chitosan-graft-polyacrylamide (CS-g-PAAm) using glutaraldehyde (GA) and as a crosslinker to be used as drug delivery matrices. Paracetamol loading into the microspheres was observed in the range of 32-73 %, and the drug release CS-g-PAAm in acidic and phosphate buffer solutions (pH 1.2-7.4) was strongly dependent on the concentration of CS-g-PAAm and crosslinker, and the paracetamol/polymer ratio.…”

Drug Micro-Carriers Based on Polymers and Their Sterilization

“…Emulsions were formulated based on different operating conditions of time and stirring speed, indicating that the emulsion systems were non-irritant with self-preserving properties and that they can be used as a template for the production of pharmaceutical and cosmetics vehicles intended for topical administration purposes [247]. E. Bulut [248] has also employed an emulsion crosslinking technique to obtain microspheres based on chitosan-graft-polyacrylamide (CS-g-PAAm) using glutaraldehyde (GA) and as a crosslinker to be used as drug delivery matrices. Paracetamol loading into the microspheres was observed in the range of 32-73 %, and the drug release CS-g-PAAm in acidic and phosphate buffer solutions (pH 1.2-7.4) was strongly dependent on the concentration of CS-g-PAAm and crosslinker, and the paracetamol/polymer ratio.…”

Design of Controlled Release System for Paracetamol Based on Modified Lignin

“…Bulut et al studied the controlled-release behavior of paracetamol using chitosan-graft-polyacrylamide microspheres via an emulsion crosslinking technique [32]. They utilized glutaraldehyde (GA) as a crosslinker to investigate its effect on the drug release rate.…”