2016
DOI: 10.1557/adv.2016.320
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Controlled Drug Release Formulation by Sequential Crosslinking of Multilayered Electrospun Gelatin Nanofiber Mat

Abstract: The major aim of the present study is to develop and explore the potential of large surface area electrospun polymer nanofabric as a carrier for controlled and sustained release, in particular for hydrophobic drugs. Gelatin (type A), FDA approved natural polymer was electrospun in a mixture of solvent (20% acetic acid in water) to yield long, continuous and uniform fibers with average diameter ∼ 200 nm. Piperine was chosen as a model hydrophobic drug in this study. As gelatin is highly soluble in aqueous mediu… Show more

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Cited by 8 publications
(5 citation statements)
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“…Using GA vapor crosslinking, Laha et al used gelatin nanofiber mats for oral drug delivery with piperine as a model drug [52,133]. By modulating the pH value of the release medium and the crosslinking efficiency, they could tailor the piperine release rate.…”
Section: Biomedical Applications Of Crosslinked Gelatin Nanofiber Matsmentioning
confidence: 99%
“…Using GA vapor crosslinking, Laha et al used gelatin nanofiber mats for oral drug delivery with piperine as a model drug [52,133]. By modulating the pH value of the release medium and the crosslinking efficiency, they could tailor the piperine release rate.…”
Section: Biomedical Applications Of Crosslinked Gelatin Nanofiber Matsmentioning
confidence: 99%
“…The enzymatic degradation was evaluated under acidic pH in the presence of pepsin, and only 6% degradation was observed in the rst 4 h. Also, acid-cured gelatin was protonated in acidic pH conditions, hence the water dissolution could not happen. 81,82 In a similar approach, Marilena Vlachou et al (2019) developed a furosemide (a diuretic drug to treat kidney failure)-loaded eudragit polymerbased nanobrous tablet using hydraulic press with a 10 mm die set. 83 The compression of the nanobres restricted uid penetration and hence achieved a slower release.…”
Section: Oral/gi Tract Routementioning
confidence: 99%
“…Although a few works have reported minimizing the use of crosslinkers either by lowering their concentration or time of exposure, a crosslinker-free approach would always be welcomed. 57,81 We can exclusively highlight the crosslinker-free drug-release studies carried out by Bhutani et al with gelatin-based hydrogels, which could be implemented with nanobre-based drug-delivery systems too. [113][114][115][116] In one such approach, a deseeded cardamom husk, a natural shell with crude bres, with a proper incision at the top, was encased with a drug-gelatin hydrogel.…”
Section: Green Electrospinningmentioning
confidence: 99%
“…The the safety profiles of GEL and PEG-CH 3 (FDA-approved polymers for biomedical applications; Dias et al, 2016;Laha et al, 2016).…”
Section: Characterization Of the Aumss Nanorods Biocompatibilitymentioning
confidence: 99%