Controlled drug release from porous materials by plasma polymer deposition

Simović, Spomenka; Lošić, Dušan; Vasilev, Krasimir

doi:10.1039/b919840g

Cited by 147 publications

(114 citation statements)

References 27 publications

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“…Indeed, porous silica lms with more disordered pore geometry had release half-lives close to two hours for negatively-charged uo-rescein isothiocyanate molecules. 6 In another study, the pore openings of NAA lms were reduced by plasma polymerization to less than 20 nm, which in turn extended release half-life to 100s of hours, 54 supporting the signicance of morphology on release kinetics and suggesting that the release half-life for np-Au thin lms can be further enhanced by tuning pore diameters via additional gold deposition and/or polymerization.…”

mentioning

confidence: 93%

Molecular release from patterned nanoporous gold thin films

2014

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Nanostructured materials have shown significant potential for biomedical applications that require high loading capacity and controlled release of drugs. Nanoporous gold (np-Au), produced by an alloy corrosion process, is a promising novel material that benefits from compatibility with microfabrication, tunable pore morphology, electrical conductivity, well-established gold-thiol conjugate chemistry, and biocompatibility. While np-Au's non-biological applications are abundant, its performance in the biomedical field is nascent. In this work, we employ a combination of techniques including nanoporous thin film synthesis, quantitative electron microscopy, fluorospectrometry, and electrochemical surface characterization to study loading capacity and molecular release kinetics as a function of film properties and discuss underlying mechanisms. The sub-micron-thick sputter-coated nanoporous gold films provide small-molecule loading capacities up to 1.12 mg cm À2 and molecular release half-lives between 3.6 hours to 12.8 hours. A systematic set of studies reveals that effective surface area of the np-Au thin films on glass substrates plays the largest role in determining loading capacity. The release kinetics on the other hand depends on a complex interplay of micro-and nano-scale morphological features.

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confidence: 93%

Molecular release from patterned nanoporous gold thin films

2014

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“…Controlling the pore diameters and lengths of TNTs by anodization process is used as a simple method to control drug re-lease characteristics, but this method has considerable limitation for applications where sustained drug release is required [16]. In our previous studies, we showed that the surface modification of pore structures via plasma polymerisation that allows control over pore diameter, has the potential to significantly improve drug delivery performance of porous and nanotubular materials [17][18][19][20]. Even, progress is encouraging; the development of new strategies able to provide sustained and controllable drug release is still required.…”

Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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Titania nanotube arrays (TNT) prepared by self-ordering electrochemical anodization have attracted considerable attention for the development of new devices for local drug delivery applications. Two approaches to extend drug release of water insoluble drugs by integrating TNTs with polymeric micelles and biopolymer coatings are presented in this work. The proposed strategies emphasized on remarkable properties of these materials and their unique combination to design local drug delivery system with advanced performance. The first concept integrates TNTs with drug loaded polymeric micelles (Pluronic F127) as drug nanocarrier, until the second concept includes polymer coating of drug loaded TNT with biodegradable polymer (chitosan). The water insoluble, anti-inflammatory drug, indomethacin was used as a model drug. Both approaches showed a significant improvement of the drug release characteristics, withreduced burst release (from 77% to 39%) and extended overall release from 9 days to more than 28 days. These results suggest the capability of TNT based systems to be applied for local drug delivery deliver over an extended period with predictable kinetics that is particularly important for bone implant therapies.

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“…The study of plasma polymer coatings that could potentially be used in biomedical devices is an area of increasing research interest [1][2][3][4][5]. One of the most common classes of thin film treatments employed in biomaterial devices is that of 'low-fouling' or 'stealth' coatings [6].…”

Section: Introductionmentioning

confidence: 99%

An X-ray and neutron reflectometry study of ‘PEG-like’ plasma polymer films

Menzies

Nelson

Shen

et al. 2011

J. R. Soc. Interface.

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Plasma-enhanced chemical vapour-deposited films of di(ethylene glycol) dimethyl ether were analysed by a combination of X-ray photoelectron spectroscopy, atomic force microscopy, quartz crystal microbalance with dissipation monitoring (QCM-D), X-ray and neutron reflectometry (NR). The combination of these techniques enabled a systematic study of the impact of plasma deposition conditions upon resulting film chemistry (empirical formula), mass densities, structure and water solvation, which has been correlated with the films' efficacy against protein fouling. All films were shown to contain substantially less hydrogen than the original monomer and absorb a vast amount of water, which correlated with their mass density profiles. A proportion of the plasma polymer hydrogen atoms were shown to be exchangeable, while QCM-D measurements were inaccurate in detecting associated water in lower power films that contained loosely bound material. The higher protein resistance of the films deposited at a low load power was attributed to its greater chemical and structural similarity to that of poly(ethylene glycol) graft surfaces. These studies demonstrate the utility of using X-ray and NR analysis techniques in furthering the understanding of the chemistry of these films and their interaction with water and proteins.

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Controlled drug release from porous materials by plasma polymer deposition

Abstract: In this communication, we present a novel approach for control of drug release from porous materials. The method is based on deposition of a plasma polymer layer with controlled thickness which reduces a pore diameter and, hence, defines the rate of drug release.

Cited by 147 publications

References 27 publications

Molecular release from patterned nanoporous gold thin films

Molecular release from patterned nanoporous gold thin films

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

An X-ray and neutron reflectometry study of ‘PEG-like’ plasma polymer films

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