Controlled grafting modification of starch and UCST-type thermosensitive behavior in water

Cai, Shuwei; Gu, Shiyu; Li, Xian; Wan, Songhan; Chen, Songbo; He, Xianru

doi:10.1007/s00396-020-04670-z

Cited by 13 publications

(6 citation statements)

References 31 publications

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“…However, intermolecular hydrogen bonds are greatly affected, preventing the polymers from aggregating into large plate-like areas. The irregular protrusions on the surfaces of the immobilized enzymes also demonstrate the successful immobilization of cellulase [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

UCST-Type Soluble Immobilized Cellulase: A New Strategy for the Efficient Degradation and Improved Recycling Performance of Wastepaper Cellulose

Chen,

Wu,

Han

et al. 2024

Molecules

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This paper reports an innovative study that aims to address key issues in the efficient recycling of wastepaper cellulose. The research team utilized the temperature-responsive upper critical solution temperature (UCST) polymer P(NAGA-b-DMA) in combination with the LytA label’s affinity for choline analogs. This innovative approach enabled them to successfully develop a novel soluble immobilized enzyme, P(NAGA-b-DMA)-cellulase. This new enzyme has proven highly effective, significantly enhancing the degradation of wastepaper cellulose while demonstrating exceptional stability. Compared with the traditional insoluble immobilized cellulase, the enzyme showed a significant improvement in the pH, temperature stability, recycling ability, and storage stability. A kinetic parameter calculation showed that the enzymatic effectiveness of the soluble immobilized enzyme was much better than that of the traditional insoluble immobilized cellulase. After the immobilization reaction, the Michaelis constant of the immobilized enzyme was only increased by 11.5%. In the actual wastepaper degradation experiment, the immobilized enzyme was effectively used, and it was found that the degradation efficiency of wastepaper cellulose reached 80% of that observed in laboratory conditions. This novel, thermosensitive soluble immobilized cellulase can efficiently catalyze the conversion of wastepaper cellulose into glucose under suitable conditions, so as to further ferment into environmentally friendly biofuel ethanol, which provides a solution to solve the shortage of raw materials and environmental protection problems in the paper products industry.

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Section: Resultsmentioning

confidence: 99%

UCST-Type Soluble Immobilized Cellulase: A New Strategy for the Efficient Degradation and Improved Recycling Performance of Wastepaper Cellulose

Chen,

Wu,

Han

et al. 2024

Molecules

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“…A similar study also found that the grafting of P(AM/AN) copolymers decreased the structural regularity of starch, resulting in a rough and irregular morphology. [ 23 ] The SEM results indicated that FA grafting changed the surface structure of the starch granules to some extent.…”

Section: Resultsmentioning

confidence: 99%

Modification of Octenyl Succinic Anhydride Starch by Grafting Folic Acid and its Potential as an Oral Colonic Delivery Carrier

Gao

Cheng

et al. 2023

Starch Stärke

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In this study, an oral colonic delivery system is designed using octenyl succinic anhydride (OSA) starch grafted with folic acid (FA). OSA starch with different degrees of substitution (DS) (0.011, 0.027, and 0.039) is prepared by reacting OSA with waxy maize starch. To optimize the drug-loading efficiency, the study choses OSA6 starch (DS = 0.027) as the substrate to prepare OSA starch grafted with FA (FA-OSA6). Fourier transform infrared spectrum confirms the successful introduction of FA. The scanning electron micrograph indicates that the surface of the FA-OSA starch granules is rough and uneven. Drug loading analysis shows that FA-OSA6 starch efficiently loaded doxorubicin hydrochloride (DOX) up to 87.71%. In vitro release studies suggest that the drug-loaded complex released only 15.8% DOX through the upper gastrointestinal tract. The cell viability assay shows that the drug-loaded complex effectively inhibits the growth of colon cancer cells (Caco-2). These results suggest that OSA6 starch grafted with FA has potential as an oral colonic delivery carrier for DOX.

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“…Above that parameter, ΔS and ΔH decrease with the increase in temperature, showing the opposite behavior to that shown by LCST polymers, and thus these materials remain miscible in solution [69,70]. Nevertheless, a phase separation governed by the enthalpy of the system occurs at temperatures below the UCST due to the balance between intra-and intermolecular forces, as well as solvation changes [71].…”

Section: Phase Transition Thermodynamics and Critical Solution Tempermentioning

confidence: 91%

Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

Henríquez¹,

Castro-Alpízar²,

Lopretti-Correa³

et al. 2020

Preprint

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innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan can be used to create biocompatible and biodegradable scaffolds with 3D architectures similar to human structures, allowing their efficient and safe use as tissue engineering and drug delivery systems in chronic wounds. Locally heated tumors above polymer lower critical solution temperature can induce its conversion into a hydrophobic form, enhancing drug release until the thermal stimulus is gone, where a lower release is due to the swelling of the material. This paper integrates the relevant reported contributions of bioengineered scaffolds for thermo-responsive drug delivery in wound healing. Therefore, we present a comprehensive review that aims to demonstrate the capacity of these systems to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D-printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to the patient’s convenience, as well as reduce drug toxicity and side effects.

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Controlled grafting modification of starch and UCST-type thermosensitive behavior in water

Cited by 13 publications

References 31 publications

UCST-Type Soluble Immobilized Cellulase: A New Strategy for the Efficient Degradation and Improved Recycling Performance of Wastepaper Cellulose

UCST-Type Soluble Immobilized Cellulase: A New Strategy for the Efficient Degradation and Improved Recycling Performance of Wastepaper Cellulose

Modification of Octenyl Succinic Anhydride Starch by Grafting Folic Acid and its Potential as an Oral Colonic Delivery Carrier

Bioengineered Scaffolds for Thermo-responsive Drug Delivery in Wound Healing

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