Controlled production of oil-in-water emulsions containing unrefined pumpkin seed oil using stirred cell membrane emulsification

Dragosavac, Marijana M.; Sovilj, Milan N.; Kosvintsev, Serguei R.; Holdich, Richard; Vladisavljević, Goran T.

doi:10.1016/j.memsci.2008.05.026

Cited by 68 publications

(52 citation statements)

References 41 publications

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“…ME is not an obvious choice for cell encapsulation: the microfilters used would be expected to filter out the suspended cells, rather than allow the passage of the cells from one side of the membrane to the other. ME being a method to produce emulsions that consists of injecting the dispersed phase for the emulsion through the pores of a membrane into another phase [37]. The detachment of the drops is produced by applying a shear over the membrane surface [38].…”

Section: Introductionmentioning

confidence: 99%

Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification

Morelli

Holdich

Dragosavac

2017

Journal of Membrane Science

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Citation: MORELLI, S., HOLDICH, R. and DRAGOSAVAC, M., 2017. Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification. Journal of Membrane Science, 524, Additional Information:• This paper was accepted for publication in the journal Journal of This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. conditions. The liquid drops were loaded with increasing amount of yeast (3.14 x 10 7 to 3.14 x 10 8 cells/ mL). The stability and uniformity of the emulsions was independent of the cell concentration. PTFE coated hydrophobic membrane produced smaller W/O drops compared to FAS coated membranes. The liquid polymeric droplets were solidified in solid particles using thermal gelation and/or ionic crosslinking, obtaining yeast encapsulated particles sized ~100 µm.The pH sensitive polymer, Eudragit S100, was used as a coating to create gastro resistant particles suitable for intestinal-colonic targeted release. Viability of the released yeast cells was demonstrated using fluorescence probes and checking cell glucose metabolism with time. AbbreviationsW/O emulsion, water in oil

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Section: Introductionmentioning

confidence: 99%

Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification

Morelli

Holdich

Dragosavac

2017

Journal of Membrane Science

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“…This figure shows that the mean vesicle size was between 50 and 100 m when 5-m membrane was used and 150 to 200 m when the membrane with a 20 m pore size was used. In membrane emulsification, the particle size was found to increase linearly with the pore size [19,25,26]. The results show that it is feasible to tune the size of liposomal particles by using microengineered membranes with different nominal pore sizes, but the effect is limited to a relatively narrow range of mean vesicle sizes.…”

Section: Effect Of the Membrane Pore Sizementioning

confidence: 88%

“…(1), and the stirrer speed was 600 rpm. Previous studies in Dispersion Cell [17,18] have shown that a shear stress is not uniformly distributed over the membrane surface, but varies with the radial distance r, according to the equations [19]:…”

Section: Experimental Procedures and Shear Stress Calculationmentioning

confidence: 99%

Preparation of liposomes: A novel application of microengineered membranes–From laboratory scale to large scale

Laouini

Charcosset

Fessi

et al. 2013

Colloids and Surfaces B: Biointerfaces

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“…The PLGA particles were produced by membrane emulsification followed by solvent evaporation and the membrane emulsification method followed here has been thoroughly described previously [1][2][3][4][5]. Specifically, its application for PLGA particle production has been reported [6], from which this work follows.…”

Section: Introductionmentioning

confidence: 99%

“…Three pore size membranes were used, 7, 20 and 40 µm in diameter, with the same pore distance equal to 200 µm. A more detailed description can be found elsewhere [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

Gasparini

Holdich

Kosvintsev

2010

Colloids and Surfaces B: Biointerfaces

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Particles for subcutaneous depot use encapsulating a model water soluble drug have been produced from poly(lactic-glycolic acid) (PLGA) using a membrane emulsification -solvent evaporation technique. The release behaviour, mainly the change in size and inner morphology are reported.During release, the particles initially swelled in size, then reduced. A diffusion based model, taking in to account the change in particle size, is presented.Surface erosion is evident from the particle size and image evidence, and the diffusion model provides a fit to the data even during the surface erosion period, suggesting that the model drug diffuses before the particle degrades.

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Controlled production of oil-in-water emulsions containing unrefined pumpkin seed oil using stirred cell membrane emulsification

Cited by 68 publications

References 41 publications

Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification

Microparticles for cell encapsulation and colonic delivery produced by membrane emulsification

Preparation of liposomes: A novel application of microengineered membranes–From laboratory scale to large scale

PLGA particle production for water-soluble drug encapsulation: Degradation and release behaviour

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