Controlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels

Peppas, Nikolaos A.; Klier, John D.

doi:10.1016/0168-3659(91)90044-e

Cited by 131 publications

(70 citation statements)

References 21 publications

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“…When functionalized polymer was desired, hydrogel synthesis remained the same and lyophilized ACR-PEG-B was added to the prepolymer mixture in an amount to give a final density of 100 nmol biotin/cm 3 . After the resulting film was washed and dried, the gel was crushed and sieved into microparticles between 90 to 150 µm (P(MAA-g-EG) PEG-B).…”

Section: Methodsmentioning

confidence: 99%

“…2 Our laboratory has successfully developed a class of environmentally sensitive complexation hydrogels containing methacrylic acid (MAA) and poly(ethylene glycol) (PEG) tethers (designated as P(MAA-g-EG)). 3,4 More specifically, P(MAAg-EG) is a pH responsive hydrogel that is capable of swelling and deswelling due to the formation of temporary physical crosslinks, or interpolymer complexes, between the PMAA pendant groups and the tethered PEG chains. Complexation of the hydrogel carrier is attributed to the hydrogen bonding between the carboxyl group of the MAA and the etheric oxygen of the PEG chains.…”

Section: Introductionmentioning

confidence: 99%

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Wheat Germ Agglutinin Functionalized Complexation Hydrogels for Oral Insulin Delivery

2008

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Insulin was loaded into hydrogel microparticles after two hours with loading efficiencies greater than 70% for both poly(methacrylic acid-grafted-ethylene glycol) (P(MAA-g-EG)) and poly(methacrylic acid-grafted-ethylene glycol) functionalized with wheat germ agglutinin (P(MAA-g-EG) WGA). The pH-responsive release results demonstrated that the pH shift from the stomach to the small intestine can be used as a physiologic trigger to release insulin from P(MAA-g-EG) and P(MAA-g-EG) WGA microparticles, thus limiting release of insulin into the acidic environment of the stomach. Microplates were successfully treated with PGM to create a surface that allowed for specific binding between mucins and lectins. The 1% PGM treatment followed by a 2 h BSA blocking step gave the most consistent results when incubated with F-WGA. In addition, the PGM-treated microplates were shown to create specific interactions between F-WGA and the PGM by use of a competitive carbohydrate. The 1% PGM treated microplates were also used to show that adhesion was improved in the P(MAA-g-EG) WGA microparticles over the P(MAA-g-EG) microparticles. The interaction between the PGM-treated microplate and P(MAA-g-EG) WGA was again shown to be specific by adding a competitive carbohydrate, while the interaction between P(MAA-g-EG) and the PGM-treated microplate was nonspecific. Cellular monolayers were used as another method for demonstrating that the functionalized microparticles increase adhesion over the nonfunctionalized microparticles. This work has focused on improving the mucoadhesive nature of P(MAA-g-EG) by functionalizing these hydrogel carriers with wheat germ agglutinin (WGA) to create a specific mucosal interaction and then evaluating the potential of these carriers as oral insulin delivery systems by in vitro methods. From these studies, it is concluded that the addition of the WGA on the microparticles produces a specific adhesion to carbohydrate-containing surfaces and that P(MAA-g-EG) WGA shows great promise as an oral insulin delivery system.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Wheat Germ Agglutinin Functionalized Complexation Hydrogels for Oral Insulin Delivery

2008

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“…ii) Characterization of PVA-Ma/PNIPAAm IPN hydrogels Many studies have been performed aiming the obtainment of hydrogels with better properties in response to external stimulus (AZEVEDO et al, 2006;GUILHERME et al, 2005;KLIER, 1991;SZILÁGYI;ZRÍNYI, 2005 enhance the mechanical properties, mainly the strength, relative to the not interpenetrated networks (BAJPAI et al, 2008;CRISPIM et al, 2006a). In the case of IPN hydrogel consisting of different polymer networks, it may display, at the same time, properties of different polymers (BAJPAI et al, 2008;DE MOURA et al, 2006).…”

Section: Results and Discussion I) Degree Of Substitution Of Pva-mamentioning

confidence: 99%

“…Hydrogel is a hydrophilic polymeric network that is able for absorbing large amounts of water, or biological fluids, without breaking its tridimensional (3D) structure (DÍEZ-PEÑA et al, 2002;KLIER, 1991). Two or more interpenetrated polymer networks constitute IPN-typed hydrogels.…”

Section: Introductionmentioning

confidence: 99%

IPN hydrogels based on PNIPAAm and PVA-Ma networks: characterization through measure of LCST, swelling ratio and mechanical properties

2012

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ABSTRACT. IPN hydrogels based on chemically modified poly(vinyl alcohol) (or PVA-Ma), with different degrees of substitution (DS), and poly(N-isopropylacrylamide) (or PNIPAAm) were obtained and characterized through measures of LCST, swelling ratio and mechanical properties. Linear PVA-Ma with several DS were obtained through the chemical reaction of PVA with glycidyl methacrylate (GMA). The DS of various PVA-Ma were determined through 1 H NMR spectroscopy. Two steps were used for preparation the PVA-Ma/PNIPAAm membrane hydrogels. In the first step the PVA-Ma hydrogels (using PVA-Ma with different DS) were prepared by reaction of double bonds on PVA-Ma, using the persulfate/TEMED system. Using a photoreaction pathway in the second step, PNIPAAm network was prepared within the parent PVA-Ma network at different PVA-Ma/NIPAAm ratios. The studies show that degree of swelling ratio (SR) of PVA-Ma/PNIPAAm IPN hydrogels is dependent of temperature. The LCST for each IPN-hydrogel was determined by measuring the intensity of light transmitted through the hydrogel. The LCST of the IPN hydrogels ranged from 34.6 to 38. Palavras-chave: hidrogéis IPN inteligentes, PNIPAAm, PVA-Ma, ajuste da LCST, sensibilidade a temperatura.

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“…Uno de los polímeros ampliamente utilizado en forma de hidrogel para aplicaciones en medicina y farmacia es el poli(N-vinil-2-pirrolidona) (P2VP) [41]. Mientras que la reticulación de este y otros polímeros mediante radiación γ fue reportada por Charlesby y Alexander [42], Nagaoka [43] aplicó radiación γ para inducir la polimerización y reticulación en Las aplicaciones biomédicas de hidrogeles con respuesta a la temperatura comenzaron a atraer la atención en la década de los 80's, particularmente basándose en los trabajos del grupo de Hoffman [48].…”

Section: Hidrogelesunclassified

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

Muñoz‐Muñoz¹,

Contreras-García²,

Bucio³

et al.

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

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Controlled release by using poly(methacrylic acid-g-ethylene glycol) hydrogels

Cited by 131 publications

References 21 publications

Wheat Germ Agglutinin Functionalized Complexation Hydrogels for Oral Insulin Delivery

Wheat Germ Agglutinin Functionalized Complexation Hydrogels for Oral Insulin Delivery

IPN hydrogels based on PNIPAAm and PVA-Ma networks: characterization through measure of LCST, swelling ratio and mechanical properties

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

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