Controlled Release from Erodible Slabs, Cylinders, and Spheres

Hopfenberg, H. B.

doi:10.1021/bk-1976-0033.ch003

Cited by 171 publications

(95 citation statements)

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“…Choosing the right mathematical model is crucial to achieve a system with optimum drug release. Currently, several models are available to describe the drug release rate from different drug delivery systems [19,20]. In this study, the used mathematical models are zero order kinetic model, first order kinetic model, Higuchi model, Korsemeyer-peppas model and Hixson-crowell model.…”

Section: Mathematical Models For Furosemide Release Studiesmentioning

confidence: 99%

Self-emulsifying Drug Delivery System (SEDDS): An Approach for Solubility, Dissolution and Bioavailability Enhancement of Furosemide

Kabir¹,

Munir²,

Rahman³

2016

SAJP

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Abstract:Furosemide is a high-ceiling (loop) diuretic, which is extensively used in the treatment of hypertension and oedema associated complications. However, when delivered orally, furosemide is poorly water-soluble and in turn suffers from poor bioavailability. The aim of this study was to investigate and develop SEDDS of furosemide and to enhance its solubility, dissolution and consequently its bioavailability. The formulation technique of this study included selection of oil phase based on solubility studies and based on emulsification abilities surfactants and co-surfactants were screened. Calibration curve was constructed to determinethe concentration of dissolved drug by using a serial dilution method. The prepared formulations of SEDDS were evaluated based on their release patterns. Mathematical models used for furosemide release studies were zero order kinetic model, first order kinetic model, Higuchi model, Korsemeyer-peppas model and Hixson-crowell model. In vitro release studies revealed that release profiles of furosemide was best expressed by Higuchi equation, as the plots showed highest linearity (coefficient of determination, R 2 = 0.94). Likewise, the formulation DS3 showed highest linearity (R 2 = 0.94). Nonetheless, poor linearity's (R 2 = 0.66 to 0.71) were found in first order and in zero order kinetic model (R 2 = 0.68 to 0.76). The results of this study clearly indicated the potential opportunity to modulate the rate and to extend the drug (furosemide) release with the used polymers and formulations. Furthermore, the results of this study strongly recommend the successful use of SEDDS to increase solubility, dissolution and in turn bioavailability of poorly soluble drugs like furosemide.

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Section: Mathematical Models For Furosemide Release Studiesmentioning

confidence: 99%

Self-emulsifying Drug Delivery System (SEDDS): An Approach for Solubility, Dissolution and Bioavailability Enhancement of Furosemide

Kabir¹,

Munir²,

Rahman³

2016

SAJP

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“…, N, according to (2.13). This release rate is derived from Hopfenberg (1976), assuming each particle is uniform and spherical with radius R. The constants k and C L represent the decay rate and particle loading, respectively. Our previous work (Miller et al, 2013) demonstrated that LTP particles distribute uniformly throughout the biofilm.…”

Section: Model Developmentmentioning

confidence: 99%

Mathematical modelling of Pseudomonas aeruginosa biofilm growth and treatment in the cystic fibrosis lung

Miller

Brantner

Clemons

et al. 2013

Mathematical Medicine and Biology

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Lung failure due to chronic bacterial infection is the leading cause of death for patients with cystic fibrosis (CF). It is thought that the chronic nature of these infections is, in part, due to the increased tolerance and recalcitrant behaviour of bacteria growing as biofilms. Inhalation of silver carbene complex (SCC) antimicrobial, either encased in polymeric biodegradable particles or in aqueous form, has been proposed as a treatment. Through a coordinated experimental and mathematical modelling effort, we examine this proposed treatment of lung biofilms. Pseudomonas aeruginosa biofilms grown in a flow-cell apparatus irrigated with an artificial CF sputum medium are analysed as an in vitro model of CF lung infection. A 2D mathematical model of biofilm growth within the flow-cell is developed. Numerical simulations demonstrate that SCC inactivation by the environment is critical in aqueous SCC, but not SCC-polymer, based treatments. Polymer particle degradation rate is shown to be an important parameter that can be chosen optimally, based on environmental conditions and bacterial susceptibility.

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“…A liberação de fármacos de sistemas com diversas geometrias em cuja superfície ocorre erosão foi objeto de estudo por Hopfenberg (1976), e mais tarde por Katzhendler et al (1997), que propôs a seguinte equação para matrizes planas, esféricas e cilíndricas apresentando erosão heterogênea:…”

Section: Modelo De Hopfenbergunclassified

Avaliação in vitro da lioequivalência de formulações farmacêuticas

Costa¹

2002

Rev. Bras. Cienc. Farm.

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A avaliação e a comparação da liberação dos fármacos a partir das formas farmacêuticas têm preocupado a indústria farmacêutica INTRODUÇÃOA avaliação e a comparação da liberação dos fármacos a partir das formas farmacêuticas têm preocupado a indústria farmacêutica e as autoridades de registro. Sempre que se produz ou desenvolve uma forma farmacêutica sólida, é necessário garantir que os fármacos sejam liberados de modo adequado. Utilizam-se, hoje em dia, diversos métodos para ajudar a decidir se diferentes formulações liberam os seus fármacos de modo semelhante. Para a realização destes estudos utilizam-se mais freqüentemente os perfis cumulativos de fármaco ao longo do tempo em oposição aos seus perfis diferenciais.Alguns métodos para comparar perfis de liberação foram recentemente propostos (CDER, 1995; Shah, Poli, 1996, Poli et al., 1997Ju, Liaw, 1997;Fassihi, Pillay, 1998;Costa, Lobo, 2001 MÉTODOS ESTATÍSTICOSOs métodos estatísticos utilizados (Tsong et al., 1996;Bartoszynski, et al., 2001) podem ser baseados em testes não-paramétricos, como o teste de Mann-Whitney (Bolton, 1984), o teste de Kolmogorov-Smirnov Z ou o teste do Qui quadrado) ou testes paramétricos (como a

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Controlled Release from Erodible Slabs, Cylinders, and Spheres

Cited by 171 publications

References 0 publications

Self-emulsifying Drug Delivery System (SEDDS): An Approach for Solubility, Dissolution and Bioavailability Enhancement of Furosemide

Self-emulsifying Drug Delivery System (SEDDS): An Approach for Solubility, Dissolution and Bioavailability Enhancement of Furosemide

Mathematical modelling of Pseudomonas aeruginosa biofilm growth and treatment in the cystic fibrosis lung

Avaliação in vitro da lioequivalência de formulações farmacêuticas

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