Controlled release from thermo-sensitive PNVCL- co -MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug

Liu, Lin; Bai, Shaoqing; Yang, Hongshan; Li, Shubai; Quan, Jing; Zhu, Li‐Min; Nie, Huali

doi:10.1016/j.msec.2016.05.083

Cited by 49 publications

(26 citation statements)

References 38 publications

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“…Results displayed in Figure 7 show that all formulations at every concentration are very biocompatible. This is similar to studies reported in literature which state that PNVCL-based hydrogels to be highly biocompatible [32,33]. In this study, the cell viability at 0.2 mg/mL is greater than or almost equal to the untreated control group, indicating excellent biocompatibility.…”

Section: Resultssupporting

confidence: 91%

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

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Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this study, however, temperature sensitive PNVCL was physically crosslinked with a pH-sensitive comonomer IA through ultraviolet (UV) free-radical polymerization, without the presence of a solvent, to produce hydrogels with dual sensitivity. The attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy indicated successful polymerisation of the hydrogels. The temperature and pH sensitivity of the hydrogels was investigated. The lower critical solution temperature (LCST) of the gels was determined using the UV spectrometry and it was found that the incorporation of IA decreased the LCST. Rheology was conducted to investigate the mechanical and viscoelastic properties of the hydrogels, with results indicating IA that enhances the mechanical properties of the gels. Swelling studies were carried out at ~20 °C and 37 °C in different buffer solutions simulating the gastrointestinal tract (pH 2.2 and pH 6.8). In acidic conditions, the gels showed gradual increase in swelling while remaining structurally intact. While in basic conditions, the gels had a burst in swelling and began to gradually degrade after 30 min. Results were similar for drug release studies. Acetaminophen was incorporated into the hydrogels. Drug dissolution studies were carried out at 37 °C in pH 2.2 and pH 6.8. It was found that <20% of acetaminophen was released from the gels in pH 2.2, whereas the maximum drug released at pH 6.8 was 74%. Cytotoxicity studies also demonstrated the hydrogels to be highly biocompatible. These results indicate that physically crosslinked P(NVCL-IA) gels possess dual pH and temperature sensitive properties, which may be beneficial for biomedical applications such as drug delivery.

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Section: Resultssupporting

confidence: 91%

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

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“…performed comparative release studies between the single PCL electrospun mat and the binary PCL/gelatin electrospun mat and found that the second mat totally suppressed the burst release of Ketoprofen and it exhibited a continuous and sustained drug release for >100 h (~4 days), while PCL fibers mat exhibited a burst release profile that reached a plateau after approximately only 12 min time at which it released ~90% of the drug. The release of ketoprofen from PNVCL‐ co ‐MAA nanofibers at different temperatures was previously evaluated by Liu et al . The results showed that slow release over several hours was observed at 40 °C (above the LCST of PNVCL‐ co ‐MAA), while the drug exhibited a burst release of several seconds at 20 °C (below the LCST).…”

Section: Resultsmentioning

confidence: 99%

“…Due to a balance between electrostatic forces and surface tension, the polymer solution or melt is projected on a grounded surface in the form of fibers that form a mesh with a structure that depends on the type of the collector used. The obtained polymeric nonwoven structures can then be employed in several applications such as filtration membranes, wound‐healing tissue, medical prostheses, scaffolds for tissue regeneration, and drug delivery, among others. In the latter case, drugs are entrapped in the fibers electrospinning polymer solutions to which the drug was previously added.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs

Sta

Aguiar

Forni

et al. 2019

J of Applied Polymer Sci

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In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N-vinylcaprolactam) (PNVCL) and its blends with poly(ε-caprolactone) and poly(N-vinylcaprolactam)-b-poly(ε-caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model-dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(Nvinylcaprolactam)-b-poly(ε-caprolactone)-based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs.

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“…In vitro drug concentration in the release media showed positive correlations with drug loading; however, no significant change was found in cumulative drug release with 50% nifedipine release at 24 h followed by 70% release at the end of the study (i.e., 72 h). The slow release behaviors were also observed for curcumin [ 95 , 96 ], ketoprofen [ 97 , 98 , 99 , 100 ], vancomycin [ 105 ], and methylene blue [ 106 ] providing the use of proper insoluble drug carriers.…”

Section: Release Of Small Molecule Drugsmentioning

confidence: 99%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

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Controlled release from thermo-sensitive PNVCL- co -MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug

Cited by 49 publications

References 38 publications

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

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