Controlled Release Imatinib Mesylate Tablet Formulation: Using Hydrophilic Matrix System

Mohajeri, Ehsan; Ansari, Mehdi; Pardakhty, Abbas

doi:10.15171/ps.2015.31

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…The formulation technology employed is beneficial for industrial applications, in the potential ease of scaling up, ease of formulation, enhanced stability of therapeutic principles and reproducibility coupled with the use of unsophisticated equipment, A simple, convenient, cost effective, and environmentally friendly method is a beneficial approach. The use of natural antimicrobials for treatment provides a holistic approach to typhoid fever management [42,43].…”

Section: Discussionmentioning

confidence: 99%

Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Adi-Dako

Kumadoh

Egbi

et al. 2021

Heliyon

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Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis. The findings indicate that the effervescent granules were suitable for use in the delivery of the therapeutic constituents for the treatment of typhoid fever as done with the decoction due to minimal herbal extract-excipient interaction.

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Section: Discussionmentioning

confidence: 99%