Controlled Release: Mechanisms and Rates

Baker, Richard W.; Lonsdale, H.K.

doi:10.1007/978-1-4684-7239-4_2

Cited by 311 publications

(162 citation statements)

References 70 publications

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“…Several theoretical models have been postulated to fit experimental release profiles, typically first-order, 41 Higuchi 42 and their combination. 43 Release generally occurs in two different steps, i.e., a rapid release of molecules that should be deposited near on the surface of fibers and a slow release that should involve the diffusion of inner molecules through the polymer bulk towards the release medium. In this way, a combined model based on the Higuchi and first-order models (eqs.…”

Section: Plots Inmentioning

confidence: 99%

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

2015

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Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.

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Section: Plots Inmentioning

confidence: 99%

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

2015

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“…To assess this and to exclude the effect of the third layer on lysozyme release, twolayered constructs were prepared, exempt from the third layer. The release of lysozyme was measured and compared to a mathematical diffusion model of drug release from PEGT/PBT films, based on Fick's second law [31,34]. The validity of this model for PEGT/PBT films has been discussed elsewhere [27], Table 1 Myoglobin and lysozyme initial diffusion coefficients from single PEGT/PBT films (D initial , cm 2 and was successfully applied to describe the release of lysozyme from 1000PEGT70PBT30 films.…”

Section: Three-layered Constructs and Releasementioning

confidence: 99%

Dual release of proteins from porous polymeric scaffolds

Sohier¹,

Vlugt

Cabrol³

et al. 2006

Journal of Controlled Release

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To create porous scaffolds releasing in a controlled and independent fashion two different proteins, a novel approach based on protein-loaded polymeric coatings was evaluated. In this process, two water-in-oil emulsions are forced successively through a prefabricated scaffold to create coatings, containing each a different protein and having different release characteristics. In a first step, a simplified three-layered system was designed with model proteins (myoglobin and lysozyme). Poly(ether -ester) multiblock copolymers were chosen as polymer matrix, to allow the diffusion of proteins through the coatings. The model system showed the independent release of the two proteins. The myoglobin release was tailored from a burst to a linear release still on-going after 60 days, while the lysozyme release rate was kept constant. Macro-porous scaffolds, with a porosity of 59 vol.%, showed the same ability to control the release rate of the model proteins independently. The relation between the coatings properties and their release characteristics were investigated with the use of a mathematical diffusion model based on Fick's second law. It confirmed that the multiple coated scaffolds are biphasic system, where each coating controls the release of the protein that it contains. This approach could be of value for tissue engineering applications. D

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“…Materials for pellet matrices must meet the following criteria: should be nontoxic; should not interact with the carcinogen/toxicant; should be easily fabricated into solid cylindrical pellets (14 (19). Invariably, an initial high release rate (burst effect) occurs (20) until the equilibrium is reached and the release takes place in a controlled fashion.…”

Section: Technology Of Pellet Productionmentioning

confidence: 99%

Heterotopic tracheal transplants: techniques and applications.

Klein‐Szanto¹,

Pal²,

Terzaghi³

et al. 1984

Environ Health Perspect

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Heterotopic tracheal transplants, placed subcutaneously in syngeneic rats have been extensively used in our laboratory. The objective of these experiments was to study the toxic and/or carcinogenic effect of several compounds on the respiratory tract mucosa. This was attained by exposing the transplants to an intraluminal pettet containing the toxicant or carcinogen mixed with an adequate matrix (gelatin, beeswax, stearyl alcohol, silastic, etc.). By varying the concentration of the test chemicals, it is possible to study dose-response relationships, and by changing the pellet matrix, the effects of release rate (dose rate) can be analyzed. Several end points can be studied, such as histological changes in the mucociliary epithelium, changes in mucus secretion, tumor induction and changes in the in vitro behavior of the epithelial cells after in vivo exposure. In addition, by de-epithelializing the tracheal transplants and reseeding them with another cell population, e.g., from previously treated cell cultures or from human specimens and transplanting them subcutaneously in nude mice, completely new vistas on the effect of chemicals can be opened.

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Controlled Release: Mechanisms and Rates

Cited by 311 publications

References 70 publications

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

Dual release of proteins from porous polymeric scaffolds

Heterotopic tracheal transplants: techniques and applications.

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