Controlled release of 5-aminosalicylicacid from chitosan based pH and temperature sensitive hydrogels

Bostan, Müge Sennaroglu; Senol, Murat; Cig, Tugce; Peker, Ismail; Goren, Ahmet C.; Öztürk, Turan; Eroğlu, Mehmet S.

doi:10.1016/j.ijbiomac.2012.09.018

Cited by 31 publications

(18 citation statements)

References 28 publications

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“…When PSA was combined with CMCS, the resulting hydro gel showed apparent pH sensitivity, similar to the property of chitosan and its derivatives. In contrast to other hydrogel systems [22][23][24], the PSA-CMCS hydrogel achieved a large swelling ratio under acidic conditions but not under neutral conditions. In addi tion, the physiochemical properties of the drugs to be loaded showed significant influences on the drug loading and release rates of the hydrogel.…”

Section: Resultscontrasting

confidence: 66%

Synthesis and characterization of polysialic acid/carboxymethyl chitosan hydrogel with potential for drug delivery

Zhan

Zheng

et al. 2015

Russ J Bioorg Chem

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A novel hydrogel was prepared from polysialic acid (PSA) and carboxymethyl chitosan (CMCS) using glutaraldehyde as the cross-linking agent. The resulting PSA-CMCS hydrogel exhibited pH sensitivity, in which the swelling ratio under acidic conditions was higher than those under neutral or alkaline conditions. The swelling ratio of PSA-CMCS hydrogel at equilibrium depended on the medium pH, the cross-linking agent concentration, and the ratio of PSA to CMCS (w/w). Bovine serum albumin (BSA) and 5-fluorouracil (5-FU) were used as model drugs to prepare hydrogel delivery systems. The loading efficiencies of the hydrogel for BSA and 5-FU were 26.25 and 36.74%, respectively. Release behaviors of BSA and 5-FU were influenced by the pH. MTT assays confirmed that PSA-CMCS hydrogel has no cytotoxicity toward the NIH-3T3 cell line; in fact, the 100% aqueous extract of the PSA-CMCS hydrogel enhanced cell growth. These results suggest that PSA-CMCS hydrogel may be a promising pH-sensitive delivery system, especially for hydrophobic chemicals.

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Section: Resultscontrasting

confidence: 66%

Synthesis and characterization of polysialic acid/carboxymethyl chitosan hydrogel with potential for drug delivery

Zhan

Zheng

et al. 2015

Russ J Bioorg Chem

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“…The proportion of the former unit depends upon the degree of deacetylation. It is a cationic polymer which is obtained by partial deacetylation of chitin and is biocompatible, biodegradable, and non-toxic [20,60]. Chitin is found in the exoskeleton of crustaceans such as shrimps, crabs, lobsters, etc.…”

Section: Base Materials For Ph Sensitive Hydrogelsmentioning

confidence: 99%

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

et al. 2017

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Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involve much expense and time. The efficacy of drugs is affected by a number of factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pK a and pK b values on the ionization, consequent swelling, and targeted drug release are also highlighted.

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“…These carboxylic groups make pectin a pH-sensitive polymer with an acidic character [36]. Chitosan is a polysaccharide composed of the copolymers glucosamine and N -acetylglucosamine and obtained by the N-deacetylation of chitin, a component present in the shell of crustaceans [39,40]. This polymer is also pH-sensitive due to the presence of amine groups, which confer a basic character [36].…”

Section: Introductionmentioning

confidence: 99%

Smart Freeze-Dried Bigels for the Prevention of the Sexual Transmission of HIV by Accelerating the Vaginal Release of Tenofovir during Intercourse

et al. 2019

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Sub-Saharan African women are still at risk from the human immunodeficiency virus (HIV), and sex with men is the main route of transmission. Vaginal formulations containing antiretroviral drugs are promising tools to give women the power to protect themselves. The aim of this work was to obtain freeze-dried bigels containing pectin, chitosan, or hypromellose for the vaginal controlled release of Tenofovir, which is accelerated in the presence of semen. Nine batches of bigels were formulated using different proportions of these polymers in the hydrogel (1, 2, and 3% w/w). The bigels obtained were freeze-dried and then underwent hardness and deformability, mucoadhesion, swelling, and drug release tests, the last two in simulated vaginal fluid (SVF) and SVF/simulated seminal fluid (SSF) mixture. The formulation containing 3% pectin (fd3P) has the highest values for hardness, resistance to deformation, and good mucoadhesivity. Its swelling is conditioned by the pH of the medium, which is responsive to the controlled release of Tenofovir in SVF, with the fastest release in the SVF/SSF mixture. fd3P would be an interesting smart microbicidal system to allow faster release of Tenofovir in the presence of semen, and thus increase women’s ability to protect themselves from the sexual transmission of HIV.

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Controlled release of 5-aminosalicylicacid from chitosan based pH and temperature sensitive hydrogels

Cited by 31 publications

References 28 publications

Synthesis and characterization of polysialic acid/carboxymethyl chitosan hydrogel with potential for drug delivery

Synthesis and characterization of polysialic acid/carboxymethyl chitosan hydrogel with potential for drug delivery

pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications

Smart Freeze-Dried Bigels for the Prevention of the Sexual Transmission of HIV by Accelerating the Vaginal Release of Tenofovir during Intercourse

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