Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers

Kabay, Gözde; Meydan, Ahmet Ersin; Can, Gizem Kaleli; Demirci, Ceylan; Mutlu, Mehmet

doi:10.1016/j.msec.2017.08.003

Cited by 32 publications

(9 citation statements)

References 41 publications

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“…Comparison of drug release rates between the experimental study of Sultanova et al [30] and our numerical results Initial drug concentration is significant for the drug release behavior, as graphically depicted in Figure 5a. When lower concentrations of the drug are loaded to the nanofibers, faster drug release is consistently observed, which agrees with the experimental study of Kabay et al [32]. While 98.05% of the loaded drug is released for CA0=0.05, 84.5% of the loaded drug is released for CA0=0.8.…”

Section: Figuresupporting

confidence: 90%

Numerical Analysis of Ampicillin Release from Electrospun Nanofibrous Mats

Canpolat

Tatlisöz

2021

Çukurova Üniversitesi Mühendislik Fakültesi Dergisi

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The electrospun nanofibrous mat is an emerging tool for drug release studies. Therefore, it is essential to predict this type of system's drug release behavior to overcome the existing problems and generate novel drug release systems. In the present work, a numerical study is performed for fulfilling this requirement, and the current numerical data is validated with the experimental study, which is available in the open literature. Transient Langmuir-Freundlich adsorption-desorption isotherm is employed for describing the drug release behavior of the electrospun nanofibrous system under perfect sink conditions. The effect of the diffusion phenomenon is also taken into account. Drug release rates are investigated for different initial drug concentrations, porosity values, permittivity mass coefficients, and mat surface areas. Moreover, the relationship between the porosity and the initial drug concentration is also presented. It can be reported that significant alterations occur in drug release rates through varied initial drug concentrations and porosity. Although the drug release rate is altered with permittivity coefficient or surface area, minor variations are observed compared to the parameters above. The results of the numerical code agree well with the experimental data.

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Section: Figuresupporting

confidence: 90%

Numerical Analysis of Ampicillin Release from Electrospun Nanofibrous Mats

Canpolat

Tatlisöz

2021

Çukurova Üniversitesi Mühendislik Fakültesi Dergisi

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“…For example, ciprofloxacin, a hydrophilic antibiotic drug for wound healing, showed burst release behavior in 2 min when incorporated into a water-soluble polymer [ 81 ] whereas sustained release of the same drug was reported up to 10 days (80% cumulative) when using a hydrophobic polymer [ 82 ]. Similar release behaviors with respect to the polymer used for small molecule hydrophilic antibiotics such as ampicillin [ 83 , 84 , 85 ], metronidazole [ 86 , 87 , 88 ], and cefazolin [ 89 , 90 ] were reported by others. In addition, drug loading in the polymer matrix plays an important role in the release mechanism of small molecule drugs from fibers.…”

Section: Release Of Small Molecule Drugssupporting

confidence: 74%

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

et al. 2018

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Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g., gels and creams) have demonstrated only a slow improvement with current available technologies. Among all available current technologies, electrospun fibers exhibit several characteristics that may provide novel replacement dressing materials for the above-mentioned wounds. Therefore, in this review, we focus on recent achievements in electrospun drug-eluting fibers for wound healing applications. In particular, we review drug release, including small molecule drugs, proteins and peptides, and gene vectors from electrospun fibers with respect to wound healing. Furthermore, we provide an overview on multifunctional dressing materials based on electrospun fibers, including those that are capable of achieving wound debridement and wound healing simultaneously as well as multi-drugs loading/types suitable for various stages of the healing process. Our review provides important and sufficient information to inform the field in development of fiber-based dressing materials for clinical treatment of non-healing wounds.

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“…Oral controlled drug release systems are characteristic in formulation, and researchers have developed electrospun nanofibers for usage in treatment and management of disorders that need special drug release patterns. Scientists have developed amyloid-like bovine serum albumin with ampicillin sodium salt nanofibers by electrospinning, and the in vitro results showed controlled release behavior [47]. Electrospun fiber mats were also investigated as drug delivery systems using tetracycline hydrochloride as a model drug.…”

Section: Electrospinning In Controlled Per Oral Drug Deliverymentioning

confidence: 99%

Electrospinning and Drug Delivery

Vlachou¹,

Siamidi²,

Kyriakou³

2019

Electrospinning and Electrospraying - Techniques and Applications

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A detailed account of the construction, properties, and practical applications of electrospinning for the fabrication of high-quality ultrafine fibers, suitable for drug delivery, is given. With respect to the electrospinning method, various parameters are of crucial importance. The electrospinning parameters are classified as solution properties, process parameters, and environmental conditions. The solution properties include the polymer concentration, molecular weight and viscosity, the solution conductivity and relative volatility, volatility of the solvent, surface tension, and dielectric constant. The process parameters refer to the flow rate, the applied voltage, the needle diameter, and the distance between the tip of the needle and collector and the geometry of the collector. The environmental conditions include the relative humidity and temperature. All these factors are responsible for a flawless electrospinning process, which leads to the formation of the desirable electrospun nanofibers with the requisite characteristics. In this chapter, it has been shown that the electrospinning technology could provide a useful method for modifying drug release behavior and opens new routes for the development of effective and tailormade drug release carriers.

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Controlled release of a hydrophilic drug from electrospun amyloid-like protein blend nanofibers

Cited by 32 publications

References 41 publications

Numerical Analysis of Ampicillin Release from Electrospun Nanofibrous Mats

Numerical Analysis of Ampicillin Release from Electrospun Nanofibrous Mats

Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications

Electrospinning and Drug Delivery

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