Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

Karakurt, Ilkay; Özaltın, Kadir; Vargün, Elif; Kučerová, Liliana; Šuly, Pavol; Harea, Evghenii; Minařík, Antonín; Štěpánková, Kateřina; Lehocký, Marián; Humpolíček, Petr; Vesel, Alenka

doi:10.1016/j.msec.2021.112125

Cited by 31 publications

(19 citation statements)

References 69 publications

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“…The hydrogels that were obtained as a result of cross-linking with vanillin have self-healing properties due to the presence of reversible hydrogen bonds. For the same reason, the hydrogels are sensitive to temperature and pH and their stability increases at lower temperatures [ 189 , 190 , 191 , 192 , 193 ].…”

Section: Cross-linking Agents From Synthetic and Natural Sourcesmentioning

confidence: 99%

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Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

2023

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The main aim of this review is to assess the potential use of natural cross-linking agents, such as genipin, citric acid, tannic acid, epigallocatechin gallate, and vanillin in preparing chemically cross-linked hydrogels for the biomedical, pharmaceutical, and cosmetic industries. Chemical cross-linking is one of the most important methods that is commonly used to form mechanically strong hydrogels based on biopolymers, such as alginates, chitosan, hyaluronic acid, collagen, gelatin, and fibroin. Moreover, the properties of natural cross-linking agents and their advantages and disadvantages are compared relative to their commonly known synthetic cross-linking counterparts. Nowadays, advanced technologies can facilitate the acquisition of high-purity biomaterials from unreacted components with no additional purification steps. However, while planning and designing a chemical process, energy and water consumption should be limited in order to reduce the risks associated with global warming. However, many synthetic cross-linking agents, such as N,N’-methylenebisacrylamide, ethylene glycol dimethacrylate, poly (ethylene glycol) diacrylates, epichlorohydrin, and glutaraldehyde, are harmful to both humans and the environment. One solution to this problem could be the use of bio-cross-linking agents obtained from natural resources, which would eliminate their toxic effects and ensure the safety for humans and the environment.

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Section: Cross-linking Agents From Synthetic and Natural Sourcesmentioning

confidence: 99%

“…Karakurt et al [ 189 ] described films based on chitosan and polyvinyl alcohol that were crosslinked with a 1% or 3% vanillin solution. Based on the SEM micrographs, the authors observed a smooth material structure with no visible pores.…”

Section: Cross-linking Agents From Synthetic and Natural Sourcesmentioning

confidence: 99%

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

2023

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“…Prem Kumar et al used an inert polymer polyvinylpyrrolidone, which, due to its excellent hydrophilic properties, caused a more efficient release of enrofloxacin [ 25 ]. On the other hand, Karakurt et al presented a transdermal sustained release system for enrofloxacin, which is based on a matrix of chitosan and vanillin-crosslinked polyvinyl alcohol [ 26 ].…”

Section: Pharmacokinetics Of Enrofloxacinmentioning

confidence: 99%

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

Grabowski

Gaffke

Pierzynowska

et al. 2022

IJMS

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Enrofloxacin is a compound that originates from a group of fluoroquinolones that is widely used in veterinary medicine as an antibacterial agent (this antibiotic is not approved for use as a drug in humans). It reveals strong antibiotic activity against both Gram-positive and Gram-negative bacteria, mainly due to the inhibition of bacterial gyrase and topoisomerase IV enzymatic actions. The high efficacy of this molecule has been demonstrated in the treatment of various animals on farms and other locations. However, the use of enrofloxacin causes severe adverse effects, including skeletal, reproductive, immune, and digestive disorders. In this review article, we present in detail and discuss the advantageous and disadvantageous properties of enrofloxacin, showing the benefits and risks of the use of this compound in veterinary medicine. Animal health and the environmental effects of this stable antibiotic (with half-life as long as 3–9 years in various natural environments) are analyzed, as are the interesting properties of this molecule that are expressed when present in complexes with metals. Recommendations for further research on enrofloxacin are also proposed.

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“…The sustained release of the antibiotic was successfully carried out by increasing the concentration of vanillin. [29] Chen et al [91] synthesized a pH and GSH dual responsive disulfide bond crosslinked chitosan film on the surface of mesoporous crosslinked silica nanoparticles for the efficient release of doxorubicin, an anticancerous drug. They found that fabricated films have excellent efficiency in preventing the premature leakage of drug.…”

Section: Chitosan Films In Drug Delivery Applicationsmentioning

confidence: 99%

Chitosan‐Based Films in Drug Delivery Applications

2022

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The idea of controlled release of the pharmaceutical active ingredients in the human body has become a major thrust for designing sophisticated drug delivery systems. The mandatory requirement for developing these delivery vehicles is to support the delivery of pharmaceutical drugs in a pharmokinetically controlled manner. Though a variety of synthetic polymers address the above mentioned conditions, their toxicity and high cost have ultimately hampered their role. Consequently, natural polymers owing to their biocompatibility, biodegradability, and nontoxicity can be used for the successful designing of drug delivery supports. One such natural polymer extracted from crustaceans, is chitosan. Chitosan can be used in drug delivery in various forms like hydrogels, nanoparticles, nanofibers, films, etc. This review presents the properties of chitosan films and their pivotal role in various drug delivery approaches.

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Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends

Cited by 31 publications

References 69 publications

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Are Natural Compounds a Promising Alternative to Synthetic Cross-Linking Agents in the Preparation of Hydrogels?

Enrofloxacin—The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections?

Chitosan‐Based Films in Drug Delivery Applications

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