Controlled release of iodine from cross-linked cyclodextrin metal-organic frameworks for prolonged periodontal pocket therapy

Lu, Shan; Ren, Xiuyan; Guo, Tao; Cao, Zeying; Sun, Hongyu; Wang, Caifen; Wang, Fangyuan; Shu, Zixuan; Jing-hua, Hao; Gui, Shuangying; Lei, Chuanhu; Zhang, Jiwen

doi:10.1016/j.carbpol.2021.118187

Cited by 40 publications

(28 citation statements)

References 41 publications

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“…Loading of iodine with nanomaterials, such as graphene, halloysite, ZIF-8, CD-MOF, etc., is a convenient way to control the loading and release behavior [15][16][17]. A cross-linked cyclodextrin metal-organic framework (CD-MOF) is used for controlled iodine loading and release [18]. A slow and sustained release of iodine is found in artificial saliva.…”

Section: Introductionmentioning

confidence: 99%

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

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Iodine has been widely used as an effective disinfectant with broad-spectrum antimicrobial potency. However, the application of iodine in an antibacterial polymer remains challenging due to its volatile nature and poor solubility. Herein, iodine immobilized UiO-66-NH2 metal-organic framework (MOF) (UiO66@I2) with a high loading capacity was synthesized and used as an effective antibacterial additive for poly(ε-caprolactone) (PCL). An orthogonal design approach was used to achieve the optimal experiments’ conditions in iodine adsorption. UiO66@I2 nanoparticles were added to the PCL matrix under ultrasonic vibration and evaporated the solvent to get a polymer membrane. The composites were characterized by SEM, XRD, FTIR, and static contact angle analysis. UiO-66-NH2 nanoparticles have a high iodine loading capacity, up to 18 wt.%. The concentration of iodine is the most important factor in iodine adsorption. Adding 0.5 wt.% or 1.0 wt.% (equivalent iodine content) of UiO66@I2 to the PCL matrix had no influence on the structure of PCL but reduces the static water angle. The PCL composites showed strong antibacterial activities against Staphylococcus aureus and Escherichia coli. In contrast, the same content of free iodine/PCL composites had no antibacterial activity. The difference in the antibacterial performance was due to the different iodine contents in the polymer composites. It was found that MOF nanoparticles could retain most of the iodine during the sample preparation and storage, while there was few iodine left in the free iodine/PCL composites. This study offers a common and simple way to immobilize iodine and prepare antibacterial polymers with low antiseptic content that would reduce the influence of an additive on polymers’ physical properties.

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Section: Introductionmentioning

confidence: 99%

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

et al. 2022

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“…In addition, the connective tissue arrangement was returned to normal, with lack of osteoclasts in the periosteum and osteoblasts being observed instead (Figure 7). These histological changes signified that following the four-week treatment with minocycline or with iodine-loaded gel the morphology of periodontal gingival tissue was restored to that which is typically observed in the healthy rat [44].…”

Section: Application To Periosteum Bonementioning

confidence: 85%

“…Successful application of γ-CD-MOFs in periosteal bone, i.e., inside the buccal cavity, was achieved by generating cross-linked derivatives that do not degrade in aqueous media. One of these gels, when loaded with the biocidal iodine, showed equivalent activity to the antibiotic drug minocycline and contributed to bone tissue regeneration [44]. These results are quite exciting as they open way for application in the repair of bone fractures.…”

Section: Overview and Future Outlookmentioning

confidence: 96%

“…Metal-Organic Frameworks have been gaining interest as drug delivery vehicles because of their high loading ability and the flexibility of construction to obtain biocompatible and biodegradable materials. The use of cyclodextrins, either as building blocks or in coatings on the particles of these materials, is a strategy developed over the last two decades that contributes to ensure better biocompatibility and to a sustained release [31,38,39,44].…”

Section: Overview and Future Outlookmentioning

confidence: 99%

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confidence: 99%

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The Emerging Role of Cyclodextrin Metal–Organic Frameworks in Ostheotherapeutics

Braga

Paz

2022

Applied Sciences

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Metal–Organic Frameworks (MOFs) are a class of coordination compounds with high versatility of design and a high loading ability. These properties have made them increasingly attractive for drug delivery, with research focusing mostly on the preparation of biocompatible MOFs. A suitable strategy is the use of cyclodextrins, cyclic oligosaccharides with excellent biosafety profiles. This review summarises the early steps taken in the application of cyclodextrin-coated and cyclodextrin-based MOFs in the treatment of bone-related diseases divided into three categories: cyclodextrin-coated MOFs, cyclodextrin-based MOFs and cross-linked derivatives of CD-MOFs. Applications in the delivery of bisphosphonates, osteoporotic regulating drugs and non-steroidal anti-inflammatory drugs, for osteoarthritis management, are highlighted. Lastly, the use of these materials in dentistry is exemplified with a recent report.

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Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

et al. 2022

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Antibiotics provide promising strategies for treating periodontitis, while their delivery and controllable release with desired oral retention remain challenging. Here, inspired by the unique suction-cup structures of abalones, a novel adhesive and photo-responsive microparticle (MP) delivery system is developed to treat periodontitis through microfluidic electrospray technology. Such MPs are generated by quickly ionic cross-linking of sodium alginate together with photo-curing of poly(ethylene glycol) diacrylate of the distorted microfluidic droplets during their high-speed dropping into calcium chloride solution. Attributing to their unique concave structures, the abalone-inspired MPs exhibit desired underwater adhesion ability and stability under running water. In addition, due to the loading of antibiotics minocycline hydrochloride and near-infrared (NIR)-responsive black phosphorus during their fabrication, the resultant MPs can not only eradicate bacteria directly, but also realize a controllable and effective drug release upon NIR irradiation. Based on these features, it is demonstrated from in vivo periodontitis that the abalone-inspired MPs are firmly adhesive and can controlled-release drugs on the tooth, and thus have outstanding antibacterial efficacy against Porphyromonas gingivalis. These results indicate the particular values of the abalone-inspired MPs for oral-related disease treatment.

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Controlled release of iodine from cross-linked cyclodextrin metal-organic frameworks for prolonged periodontal pocket therapy

Cited by 40 publications

References 41 publications

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

Iodine Immobilized UiO-66-NH2 Metal-Organic Framework as an Effective Antibacterial Additive for Poly(ε-caprolactone)

The Emerging Role of Cyclodextrin Metal–Organic Frameworks in Ostheotherapeutics

Abalone‐Inspired Adhesive and Photo‐Responsive Microparticle Delivery Systems for Periodontal Drug Therapy

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