Controlled-Release Theophylline Inhibits Early Morning Airway Obstruction and Hyperresponsivenes in Asthmatic Subjects

Effect of specific immunotherapy added to pharmacologic treatment and allergen avoidance in asthmatic patients allergic to house dust mite

“…The sample size was estimated a priori on the basis of previous experience with PD 20 FEV 1 . 15 Assuming a minimum significant difference of 2-fold methacholine doses, 28 subjects in each group would be required to reject the null hypothesis at the 5% significance level for 90% power. Quantitative data are presented as means ± SDs.…”

Diagnosis and Management of Work-Related Asthma

“…Other Medical Regimens Used During SICs: Studies have assessed the effect of medications on asthmatic responses and airway responsiveness induced by various occupational sensitizing agents (mainly diisocyanates and flour) during SICs in subjects with sensitizer-induced OA. [233][234][235][236][237] Although these data bring additional information on pathophysiology, they have a limited impact on the pharmacologic management of patients with sensitizer-induced OA.…”

Outpatient treatment of chronic obstructive pulmonary disease: Comparisons with asthma

“…89 The use of low-dose theophylline appears to reduce the number of activated lymphocytes in the peripheral blood after allergen challenge, 90 and in subjects with nocturnal asthma, theophylline results in significant reductions in the percentage of bronchoalveolar lavage neutrophils and eosinophils at 4 AM. 91 Theophylline also protects against airway responsiveness in asthma, 92,93 but despite the antiinflammatory effects of theophylline, the results from multiple clinical trials indicate that methyl xanthines are inferior to inhaled corticosteroids in the treatment of chronic asthma.…”