Controlled sulfation of poly(vinyl alcohol) for biological and technical applications using response surface methodology

Solhi, Laleh; Sun, He Song; Daswani, Sailesh Haresh; Springate, Christopher M. K.; Brumer, Harry

doi:10.1039/d0me00139b

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Furthermore, the FT-IR results reveal that the OH peak observed at ∼3300 cm –1 smears out after c-H 2 SO 4 treatment, while the observed blue shift persists. These results can be explained by the partial sulfation of PVA by the reaction between c-H 2 SO 4 and the hydroxyl groups of PVA (see the chemical structures in Figure a). – Therefore, the suggested mechanism of HG is as follows (Figure e). H 2 SO 4 molecules penetrate into the cross-linked PVA–PSS solid by weakening the hydrogen bonds in PVA crystallites and a certain number of hydroxyl groups are converted into sulfate groups.…”

Section: Results and Discussionmentioning

confidence: 99%

Synthesis of Superabsorbent Hydrogels with Predefined Geometries and Controlled Swelling Properties for Versatile 3D Cell Culture Scaffolds

Kang,

Wang,

Goh

et al. 2024

ACS Appl. Mater. Interfaces

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This research presents a simple but general method to prepare water-soluble-polymer-based superabsorbent hydrogels with predefined microscale geometries and controlled swelling properties. Unlike conventional hydrogel preparation methods based on bulk solution-phase cross-linking, poly(vinyl alcohol) is homogeneously mixed with polymer-based cross-linkers in the solution phase and thermally cross-linked in the solid phase after drying; the degree of cross-linking is modulated by controlling the cross-linker concentration, pH, and/or thermal annealing conditions. After the shape definition process, cross-linked films or electrospun nanofibers are treated with sulfuric acid to weaken hydrogen bonds and introduce sulfate functionality in polymer crystallites. The resultant superabsorbent hydrogels exhibit an isotropic expansion of the predefined geometry and tunable swelling properties. Particularly, hydrogel microfibers exhibit excellent optical transparency, good biocompatibility, large porosity, and controlled cell adhesion, leading to versatile 3D cell culture scaffolds that not only support immortalized cell lines and primary neurons but also enable stiffness-modulated cell adhesion studies.

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Section: Results and Discussionmentioning

confidence: 99%

Synthesis of Superabsorbent Hydrogels with Predefined Geometries and Controlled Swelling Properties for Versatile 3D Cell Culture Scaffolds

Kang,

Wang,

Goh

et al. 2024

ACS Appl. Mater. Interfaces

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Controlled sulfation of mixed-linkage glucan by Response Surface Methodology for the development of biologically applicable polysaccharides

Solhi

Sun²,

Daswani³

et al. 2021

Carbohydrate Polymers

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Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin–expressing cancers

Koshrovski-Michael,

Ajamil,

Dey

et al. 2024

Sci. Adv.

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Combined therapies in cancer treatment aim to enhance antitumor activity. However, delivering multiple small molecules imposes challenges, as different drugs have distinct pharmacokinetic profiles and tumor penetration abilities, affecting their therapeutic efficacy. To circumvent this, poly(lactic-co-glycolic acid) (PLGA)–polyethylene glycol (PEG)–based nanoparticles were developed as a platform for the codelivery of synergistic drug ratios, improving therapeutic efficacy by increasing the percentage of injected dose reaching the tumor. Nonetheless, extravasation-dependent tumor accumulation is susceptible to variations in tumor vasculature; therefore, PLGA-PEG was modified with sulfates to actively target P-selectin–expressing cancers. Here, we show the potential of our platform in unique three-dimensional (3D) in vitro and in vivo models. The P-selectin–targeted nanoparticles showed enhanced accumulation in 3D spheroids and tissues of P-selectin–expressing BRAF-mutated melanomas and BRCA-mutated breast cancers, resulting in superior in vivo efficacy and safety. This nanoplatform could advance the codelivery of a plethora of anticancer drug combinations to various P-selectin–expressing tumors.

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Controlled sulfation of poly(vinyl alcohol) for biological and technical applications using response surface methodology

Abstract: Sulfated polymers are widely used for diverse applications in chemistry and biology due to their polyanionic nature. Sulfated poly(vinyl alcohol) (SPVA) represents one of the most broadly useful sulfated polymers,...

Cited by 3 publications

References 41 publications

Synthesis of Superabsorbent Hydrogels with Predefined Geometries and Controlled Swelling Properties for Versatile 3D Cell Culture Scaffolds

Synthesis of Superabsorbent Hydrogels with Predefined Geometries and Controlled Swelling Properties for Versatile 3D Cell Culture Scaffolds

Controlled sulfation of mixed-linkage glucan by Response Surface Methodology for the development of biologically applicable polysaccharides

Two-in-one nanoparticle platform induces a strong therapeutic effect of targeted therapies in P-selectin–expressing cancers

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