Controlled Synthesis of Au Nanoparticles by Modified Polyol Methods: Determination of Their Size, Shape, and Crystal Structure

Hang, Nguyen Thi Nhat; Yang, Yong; Nam, Nguyen Quang Thanh; Nogami, Masayuki; Phuc, Le Hong; Tri, Nguyen Huu; Cừu, Hồ Văn; Long, Nguyen Viet

doi:10.3390/cryst11111297

Cited by 8 publications

(2 citation statements)

References 25 publications

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“…Our discovery of Au@Alg-DA nanoparticles, which are spherical and uniform, measures approximately 8.7 nm. This finding is consistent with earlier research that used biopolymer-based methods to synthesize gold nanoparticles 37 , 38 . However, other studies indicate that even smaller sizes can be achieved by modifying the biopolymer used and adjusting reaction conditions 39 , 40 .…”

Section: Resultssupporting

confidence: 93%

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Ghaffarlou,

Rashidzadeh,

Mohammadi

et al. 2024

Sci Rep

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Radiation therapy and phototherapy are commonly used cancer treatments that offer advantages such as a low risk of adverse effects and the ability to target cancer cells while sparing healthy tissue. A promising strategy for cancer treatment involves using nanoparticles (NPs) in combination with radiation and photothermal therapy to target cancer cells and improve treatment efficacy. The synthesis of gold NPs (AuNPs) for use in biomedical applications has traditionally involved toxic reducing agents. Here we harnessed dopamine (DA)-conjugated alginate (Alg) for the facile and green synthesis of Au NPs (Au@Alg-DA NPs). Alg-DA conjugate reduced Au ions, simultaneously stabilized the resulting AuNPs, and prevented aggregation, resulting in particles with a narrow size distribution and improved stability. Injectable Au@Alg-DA NPs significantly promoted ROS generation in 4T1 breast cancer cells when exposed to X-rays. In addition, their administration raised the temperature under a light excitation of 808 nm, thus helping to destroy cancer cells more effectively. Importantly, no substantial cytotoxicity was detected in our Au@Alg-DA NPs. Taken together, our work provides a promising route to obtain an injectable combined radio enhancer and photothermally active nanosystem for further potential clinic translation.

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Section: Resultssupporting

confidence: 93%

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Ghaffarlou,

Rashidzadeh,

Mohammadi

et al. 2024

Sci Rep

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“…These obtained results corroborate with previously reported results. [53][54][55] Apart from the distinct peaks, few other peaks were observed (denoted as "*" in the Figure 4), and among them, two peaks between 20° and 30° 2 theta angle might be due to the presence of different amino acids in the sericin. 50 To identify the major functional groups present in the SSP and SSP-AuNPs, the FT-IR analysis was carried out.…”

Section: Dovepressmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles by Using Sericin Protein from Bombyx mori Silk Cocoon and Investigation of Its Wound Healing, Antioxidant, and Antibacterial Potentials

Das¹,

Seo²,

Yang³

et al. 2023

IJN

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Introduction A number of biological wastes and factory waste materials have been tested recently for the eco-friendly biosynthesis of nanoparticles. Sericin protein (SSP) is usually removed from the silk cocoon during the degumming process in the process of making the silk, and this sericin protein is normally thrown away by the sericulture industries as waste materials. It is found that this sericin protein possesses a number of biological properties. Methods Considering this, in the present study, an effort has been made to biosynthesize gold nanoparticles (SSP-AuNPs) using the waste sericin solution as the reducing and capping agent and investigate its biopotential in terms of its wound healing, antioxidant and antibacterial activities. Results The synthesis of SSP-AuNPs was perceived by the visual color change and confirmed by UV-Vis spectroscopy with absorption maxima at 522 nm. Further characterization of SSP-AuNPs was done by TEM, EDS, XRD, FTIR, DLS, zeta potential, TGA, AFM, etc. The size of SSP-AuNPs was found out to be 54.82 nm as per the particle size analyzer and the zeta potential is −19.8 mV. The SSP-AuNPs displayed promising wound healing potential of 70.96 and 69.76% wound closure rate at 5 and 10 µg/mL respectively as compared to 74.91% by the Centella asiatica taken as a positive control. It also exhibited promising antioxidant potential in terms of the DPPH, ABTS free radical scavenging, reducing power potential, and total antioxidant capacity. Besides, the SSP-AuNPs also displayed significant antibacterial activities against the tested pathogenic bacterial with the diameter of inhibition zones ranging between 12.10 and 14.96 mm as compared to the positive control cephalexin that displayed inhibition zones ranging between 12.08 and 13.24 mm. Discussion Taken together, SSP-AuNPs could serve as an interesting candidate for food, cosmetics, and biomedical fields in the applications of wound healing, cosmetics, antibacterial bandages, and ointments, etc.

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Comparative performance analysis of mussel-inspired polydopamine, polynorepinephrine, and poly-α-methyl norepinephrine in electrochemical biosensors

Bisht,

Patel,

Mondal

et al. 2024

Microchim Acta

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Controlled Synthesis of Au Nanoparticles by Modified Polyol Methods: Determination of Their Size, Shape, and Crystal Structure

Cited by 8 publications

References 25 publications

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Photothermal and radiotherapy with alginate-coated gold nanoparticles for breast cancer treatment

Synthesis of Biogenic Gold Nanoparticles by Using Sericin Protein from Bombyx mori Silk Cocoon and Investigation of Its Wound Healing, Antioxidant, and Antibacterial Potentials

Comparative performance analysis of mussel-inspired polydopamine, polynorepinephrine, and poly-α-methyl norepinephrine in electrochemical biosensors

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