Controlled Synthesis of Peptide-Based Amphiphilic Copolymers

Supramolecular Self‐Assembly of Nonlinear Amphiphilic and Double Hydrophilic Block Copolymers in Aqueous Solutions

“…The incorporation of polypeptide sequences, such as pH‐responsive poly( L ‐lysine) (PLL) and PLGA, into DHBCs can endow them with additional structural versatility, tunable spatial arrangement of chain segments within self‐assembled nanostructures, enhanced biocompatibility and broader applications in the field of biomedicines, which represents a promising new direction in the field of DHBCs. Previous literature reports mainly focused on linear purely polypeptide‐based or polypeptide hybrid block copolymers 71, 72. In two notable examples, Lecommandoux et al73 reported that linear PLGA‐ b ‐PLL diblock copolymer can self‐assemble in aqueous solution into two types of unilamellar vesicles at pH 3 and 12, respectively, by taking advantage of the formation of secondary structures and block composition asymmetry.…”

Polymer gene delivery vectors encapsulated in thermally sensitive bioreducible shell

“…5 Thus, numerous copolymers of various architectures with cationic segments and potential application in gene delivery systems were synthesized. [6][7][8] Besides the low toxicity these copolymers may impart other properties to the gene delivery vehicles such as 'smart' response to environmental changes and targeting functions. 9,10 However, in all cases a surplus of positively charged copolymers must be used to form stable polyplexes.…”

Preparation and aggregation behavior of mannose-terminated poly(ethylene glycol)-b-poly(l-leucine) in water

“…The relative integration ratio of these two peaks was close to 1:1, thus confirming the proposed structure of the purified product. The above prepared N 3 -PEG-NH 2 ·HCl was then used as a macroinitiator to initiate the ROP of Leu-NCA in DMF [27][28][29]32,42,43]. We prepared three polymer samples with different chain lengths of PLeu by varying the molar ratio of Leu-NCA to initiator N 3 -PEG-NH 2 ·HCl (Table 1).…”

“…With a macroinitiator, polypeptidebased hybrid block copolymers can be prepared with this method. Recent progress in the controlled ROP of NCA has enabled the synthesis of well-defined copolypeptides and hybrid copolymers with lower polydispersities [24][25][26][27][28][29][30][31]. The primary amine hydrochloride macroinitiator initiated ROP of NCA has proved to be a simple and easily handled approach to prepare well-defined hybrid copolymers.…”

“…The primary amine hydrochloride macroinitiator initiated ROP of NCA has proved to be a simple and easily handled approach to prepare well-defined hybrid copolymers. Amine hydrochloride end-functionalized poly(ethylene glycol) (PEG) is among the most widely used macroinitiators to endow polypeptide-based hybrid block copolymers with watersoluble and biocompatible properties [28,32].…”