Controlled Synthesis of Water Soluble Silver Nanoparticles and the Molluscicidal Effect

Yang, Xiao Hong; Wang, Jiang Jie; Ge, Jun; Wang, Jin Sheng; Dong, Fengquan

doi:10.4028/www.scientific.net/amr.399-401.527

Cited by 5 publications

(5 citation statements)

References 25 publications

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“…Second, our study highlighted that the longer the snails’ exposure to SNP, the higher the molluscicidal activity of SNP to snails. A similar result was also observed by Yang et al [ 36 ], who showed that all Oncomelania snails exposed to SNP were dead after 144 hrs [ 2 ]. Our study revealed that Ag-NPs molluscicidal activity is concentration-dependent ( Fig 2 ).…”

Section: Discussionsupporting

confidence: 86%

“…In order to reach the active center of CAT, H 2 O 2 needs to diffuse inside a narrow channel made of 14 amino acids. The decrease in the activity of CAT could also be illustrated by the interaction of Ag + ions released by Ag-NPs, and by amino acid residues within this narrow channel [ 43 ], impeding the approach of H 2 O 2 to the active center and decreasing the soluble CAT activity [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

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Molluscicidal and antioxidant activities of silver nanoparticles on the multi-species of snail intermediate hosts of schistosomiasis

Zayed

Guo²,

Lv³

et al. 2022

PLoS Negl Trop Dis

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Background Schistosomiasis, also known as bilharzia, is the second important parasitic disease after malaria. The present study aimed to evaluate the molluscicidal effects of silver nanoparticles on Biomphalaria alexandrina, B. glabrata, Oncomelania hupensis, snail intermediate hosts of intestinal schistosomes (i.e. Schistosoma mansoni and S. japonicum), along with the changes their antioxidant enzymes. Methods Silver (Ag) nano powder (Ag-NPs) was selected to test the molluscicidal effects on three species of freshwater snails. Exposure to Ag-NPs induced snail mortality and the LC50 and LC90 values of Ag-NPs for each snail species were calculated by probit analysis. Control snails were maintained under the same experimental conditions in dechlorinated water. Snail hemolymph was collected to measure the levels of antioxidant enzymes, such as total antioxidants capacity (TCA), glutathione (GSH), catalase (CAT) and nitric oxide (NO). In addition, the non-target organism, Daphnia magna, was exposed to a series of Ag-NPs concentration, similar to the group of experimental snails, in order to evaluate the LC50 and LC90 and compare these values to those obtained for the targeted snails. Results The results indicated that Ag-NPs had a molluscicidal effect on tested snails with the variation in lethal concentration. The LC50 values of Ag-NPs for B. alexandrina snails exposed for 24, 48, 72 hrs and 7 days were 7.91, 5.69, 3.83 and 1.91 parts per million (ppm), respectively. The LC50 values for B. glabrata snails exposed for 24, 48, 72 hrs and 7 days were 16.55, 10.44, 6.91 and 4.13 ppm, respectively, while the LC50 values for O. hupensis snails exposed for 24, 48, 72 hrs and 7 days were 46.5, 29.85, 24.49 and 9.62 ppm, respectively. Moreover, there is no mortality detected on D. magna when exposed to more than double and half concentration (50 ppm) of Ag-NPs during a continuous period of 3 hrs, whereas the LC90 value for B. alexandrina snails was 18 ppm. The molluscicidal effect of the synthesized Ag-NPs seems to be linked to a potential reduction of the antioxidant activity in the snail’s hemolymph. Conclusions Synthesized Ag-NPs have a clear molluscicidal effect against various snail intermediate hosts of intestinal schistosome parasites and could potentially serve as next generation molluscicides.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Molluscicidal and antioxidant activities of silver nanoparticles on the multi-species of snail intermediate hosts of schistosomiasis

Zayed

Guo²,

Lv³

et al. 2022

PLoS Negl Trop Dis

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“…So that our experimental results have reached a new nding that the membrane could be worsened by the creation of pits on the surface of the cell wall membrane, the creation of pits on the membrane resulted in an increase in the permeability and irregular transport that caused the death of the cells. Besides, [31] observed that all Oncomelania snails were dead after 144 h under the condition of SNP existence [2], which revealed that Ag-NPs have molluscicidal activity against B. alexandrina and cercaricidal in a concentration-dependent manner. In addition, the great impact of Ag-NPs on cercariae was due to Ag ions, which are unceasingly released in water suspension and can bind to the papillary sites on the cercarial surface, thereby, inhibiting fatty acid-induced cercarial acetabular gland secretion [32].…”

Section: Discussionmentioning

confidence: 96%

“…In order to reach the active center of CAT, H 2 O 2 needs to diffuse inside a narrow channel made of 14 amino acids, inside this channel. The decrease in the activity of CAT could also be illustrated by the interaction of Ag + ions released by Ag-NPs, and by amino acid residues within this narrow channel [38] impeding the approach of H 2 O 2 to the active center and decreasing the soluble CAT activity [31].…”

Section: Discussionmentioning

confidence: 99%

Molluscicidal and Antioxidant Activities of Silver Nanoparticles on the Snail Intermediate Hosts of Schistosomiasis

Zayed¹,

Guo²,

Zhou³

2021

Preprint

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Background: Schistosomiasis, also known as bilharzia, is a disease caused by parasitic worms. This disease is the second important parasitic disease after malaria in terms of its burden of disease. Methods: One of control intervention for schistosomiasis control programme is to perform the mollusciciding to interrupt the transmission through snail intermediate host where the parasites developed from miracidia to cercaria that is the infective stage. Accordingly, it is possible to improve the molluscicding effects after adding nanoparticulate agents in molluscicides. Results: This research field has caused more attention, since silver nanoparticles (Ag-NPs) were characterized by the transmission electron micrographs (TEM) with X-Ray fluorescence (XRF), showed that it’s mostly spherical in shape with average particle size diameters 20nm with high purity of synthesized particles (99.99%) of element was Ag. The aim of the present study is to demonstrate the molluscicidal effects of Ag-NPs against the three species of snails, including two species of intermediate snail host of Schistosoma mansoni (Biomphalaria alexandarina and Biomphalria glabrata) and one species of intermediate snail host of S. japonicum (Oncomelania hupensis), and the cercaricidal effects of Ag-NPs against Schistosoma mansoni cercariae. At the same time, their effects on snail’s antioxidant enzymes, e.g. catalase (CAT), glutathione reduced (GSH), nitric oxide (NO) and total antioxidants capacity (TAC), and on freshwater cladoceran (crustacean) Daphnia magna that represent the potential toxicity to other aquatic organisms were observed as well. The results indicated that Ag-NPs had a molluscicidal effect on tested snails with the variation in lethal concentration dose. LC50 of Ag-NPs exposure for 24, 48, 72 hrs and 7 days to B. alexandrina snails was 7.91, 5.69, 3.83 and 1.91 ppm respectively, LC50 for 24, 48, 72 hrs and 7 days exposure to B. glabrata snails was 16.55, 10.44, 6.91 and 4.13 ppm respectively, while LC50 for 24, 48, 72 hrs and 7 days exposure to Oncomelania hupensis snails was 46.5, 29.85, 24.49 and 9.62 ppm respectively. While the cercaricidal effects on S. mansoni cercariae was fast, since the lethal time LT50 and LT90 exposed to Ag-NP with 80 ppm concentration was 27 min and 45 min, respectively; and its 100 ppm exposed was 15min and 41 min, respectively. Moreover, there is no mortality rate to Daphnia magna when exposed to more than double and half dose (50 ppm) of Ag-NPs for continuous 3 hs, of which LC90 to B. alexandarina snails was 18 ppm. Conclusions: The synergistic effect of synthesized Ag-NPs as molluscicidal and cercaricidal was clearly revealed that it’s promising to be effectively used against various intermediate host snails of intestinal schistosomes and reduced it’s a potential antioxidant activity.

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“…Another strategy for controlling schistosomiasis is by combating the mollusk vector Biomphalaria glabrata through the use of metal nanoparticles. Silver nanoparticles have been studied as a molluscicidal with low toxicity to other aquatic organisms (Yang et al, 2011;Guang et al, 2013).…”

Section: Schistosomiasismentioning

confidence: 99%

Nanopharmaceuticals as a solution to neglected diseases: Is it possible?

et al. 2017

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The study of neglected diseases has not received much attention, especially from public and private institutions over the last years, in terms of strong support for developing treatment for these diseases. Support in the form of substantial amounts of private and public investment is greatly needed in this area. Due to the lack of novel drugs for these diseases, nanobiotechnology has appeared as an important new breakthrough for the treatment of neglected diseases. Recently, very few reviews focusing on filiarasis, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, trypanosomiasis, and tuberculosis, and dengue virus have been published. New developments in nanocarriers have made promising advances in the treatment of several kinds of diseases with less toxicity, high efficacy and improved bioavailability of drugs with extended release and fewer applications. This review deals with the current status of nanobiotechnology in the treatment of neglected diseases and highlights how it provides key tools for exploring new perspectives in the treatment of a wide range of diseases.

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Controlled Synthesis of Water Soluble Silver Nanoparticles and the Molluscicidal Effect

Cited by 5 publications

References 25 publications

Molluscicidal and antioxidant activities of silver nanoparticles on the multi-species of snail intermediate hosts of schistosomiasis

Molluscicidal and antioxidant activities of silver nanoparticles on the multi-species of snail intermediate hosts of schistosomiasis

Molluscicidal and Antioxidant Activities of Silver Nanoparticles on the Snail Intermediate Hosts of Schistosomiasis

Nanopharmaceuticals as a solution to neglected diseases: Is it possible?

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