Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials

Asefa, Tewodros; Otuonye, Amy N.; Wang, Gang; Blair, E.; Vathyam, Rajyalakshmi; Denton, Kelley

doi:10.1007/s10450-009-9176-7

Cited by 14 publications

(7 citation statements)

References 54 publications

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“…Due to the presence of silanol groups on their surface, nanoporous silica materials have a versatile surface chemistry. These groups can be used for the coupling of other silanes and thus the functionalization with a wide variety of functional groups [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

et al. 2018

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BackgroundIn orthopedic surgery, implant-associated infections are still a major problem. For the improvement of the selective therapy in the infection area, magnetic nanoparticles as drug carriers are promising when used in combination with magnetizable implants and an externally applied magnetic field. These implants principally increase the strength of the magnetic field resulting in an enhanced accumulation of the drug loaded particles in the target area and therewith a reduction of the needed amount and the risk of undesirable side effects. In the present study magnetic nanoporous silica core–shell nanoparticles, modified with fluorophores (fluorescein isothiocyanate/FITC or rhodamine B isothiocyanate/RITC) and poly(ethylene glycol) (PEG), were used in combination with metallic plates of different magnetic properties and with a magnetic field. In vitro and in vivo experiments were performed to investigate particle accumulation and retention and their biocompatibility.ResultsSpherical magnetic silica core–shell nanoparticles with reproducible superparamagnetic behavior and high porosity were synthesized. Based on in vitro proliferation and viability tests the modification with organic fluorophores and PEG led to highly biocompatible fluorescent particles, and good dispersibility. In a circular tube system martensitic steel 1.4112 showed superior accumulation and retention of the magnetic particles in comparison to ferritic steel 1.4521 and a Ti90Al6V4 control. In vivo tests in a mouse model where the nanoparticles were injected subcutaneously showed the good biocompatibility of the magnetic silica nanoparticles and their accumulation on the surface of a metallic plate, which had been implanted before, and in the surrounding tissue.ConclusionWith their superparamagnetic properties and their high porosity, multifunctional magnetic nanoporous silica nanoparticles are ideal candidates as drug carriers. In combination with their good biocompatibility in vitro, they have ideal properties for an implant directed magnetic drug targeting. Missing adverse clinical and histological effects proved the good biocompatibility in vivo. Accumulation and retention of the nanoparticles could be influenced by the magnetic properties of the implanted plates; a remanent martensitic steel plate significantly improved both values in vitro. Therefore, the use of magnetizable implant materials in combination with the magnetic nanoparticles has promising potential for the selective treatment of implant-associated infections.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0422-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

et al. 2018

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“…On the other hand, the porous matrices that contain amine functional groups showed greater adsorption capacity and better release properties for ibuprofen molecules. Improved adsorption and release properties of porous materials by simple changes of functional groups on the porous channels walls are the key for drug delivery systems [27]. Poor aqueous solubility is acknowledged as one of the major barriers in the development of novel pharmaceutical agents.…”

Section: Porous Materials For a Drug Deliverymentioning

confidence: 99%

Micro, Meso and Macro Porous Materials on Medicine

Solano-Umaña¹,

Vega-Baudrit²

2015

JBNB

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An enormous development is experimented on the porous materials. The porous was considered a defect on solid materials some years ago, but right now, this defect is an advantage, based on the properties obtained from a micro and mesoporous materials. Microporous, mesoporous and macroporous materials with an uniformed pore distribution offer new properties, such as absorption, adsorption, exchange separation, and catalysis of different compounds, also they can play different roles as hosts for a nanocomposite materials to modify or improve their properties. Today, the structural types of open framework porous compounds have rapidly increased by their unique structural properties, porous size window and accessible void space are critical factors on a medical application.

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“…By coating or grafting functional groups on mesoporous materials, it can be made feasible for the development of functionalized mesoporous material drug delivery vehicles and for controlled release of drugs over extended periods. By selecting organic groups and deploying systematic design and fabricate approaches, nanoporous materials having different adsorption capacities and release properties for many drug molecules can be achieved [28,29]. Amino group modified mesoporous materials were intensively investigated for controlled release of small molecular acidic drugs.…”

Section: Drug-host Interaction Controlmentioning

confidence: 99%

Applications of Mesoporous Materials as Excipients for Innovative Drug Delivery and Formulation

Shen¹,

Chia³

et al. 2013

CPD

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Due to uniquely ordered nanoporous structure and high surface area as well as large pore volume, mesoporous materials have exhibited excellent performance in both controlled drug delivery with sustained release profiles and formulation of poorly aqueoussoluble drugs with enhanced bioavailability. Compared with other bulk excipients, mesoporous materials could achieve a higher loading of active ingredients and a tunable drug release profile, as the high surface density of surface hydroxyl groups offered versatility to be functionalized. With drug molecules stored in nano sized channels, the pore openings could be modified using functional polymers or nano-valves performing as stimuli-responsive release devices and the drug release could be triggered by environmental changes or other external effects. In particular, mesoporous silica nanoparticles (MSN) have attracted much attention for application in functional target drug delivery to the cancer cell. The smart nano-vehicles for drug delivery have showed obvious improvements in the therapeutic efficacy for tumor suppression as compared with conventional sustained release systems, although further progress is still needed for eventual clinical applications. Alternatively, unmodified mesoporous silica also exhibited feasible application for direct formulation of poorly water-soluble drugs to enhance dissolution rate, solubility and thus increase the bioavailability after administration. In summary, mesoporous materials offer great versatility that can be used both for on-demand oral and local drug delivery, and scientists are making great efforts to design and fabricate innovative drug delivery systems based on mesoporous drug carriers.

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Controlling adsorption and release of drug and small molecules by organic functionalization of mesoporous materials

Cited by 14 publications

References 54 publications

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

Micro, Meso and Macro Porous Materials on Medicine

Applications of Mesoporous Materials as Excipients for Innovative Drug Delivery and Formulation

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