Controlling Fiber Morphology and Scaffold Design for Treatment of Dry Age-Related Macular Degeneration

Haneef, Atikah; Downes, S.

doi:10.1080/00914037.2014.886231

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…The persistent substrate has already been designed [81,82] and work has been undertaken to optimise fabrication of nanoparticles and encapsulation of detectable compounds to measure nanoparticle degradation and sustained release [83].…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

Biomaterials Targeting AMD: Are We There Yet?

Lawless¹,

Hidalgo-Alvarez²,

Haneef³

2020

Preprint

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Age-related macular degeneration (AMD) is the leading cause of central blindness in developed countries. It affects people mainly over the age of 50 years. It is a disease of the macula, an area of the retina responsible for sharp central vision. It particularly affects the Bruch’s membrane (BM); a layer in the retina that acts as the basement upon which retinal pigment epithelial cells (RPE) attach and survive. The pathology of AMD is not fully understood, but age is considered the main risk factor. There are two forms; nonexudative, leading to the end-stage of the disease, called nonexudative (or dry) AMD (90% of cases) where fatty deposits called drusen form under the RPE on top of the BM lifting off the RPE, and neovascular (or wet) AMD (10% of cases) where abnormal new blood vessels grow and push through the BM, bleeding in and disrupting the RPE. Neovascular AMD is well controlled with regular antiangiogenic drug injections of anti-vascular endothelial growth factor (anti-VEGF) into the eye, whereas there is no current treatment for nonexudative AMD. Many research groups across the world are working on a treatment for nonexudative AMD. This review discusses the research currently being conducted including cell therapies, development of cell transplantation membranes, targeting other disease structures in affected retina (i.e. drusen), and drug delivery to the retina using nanoparticles. Finally, we include our research contributing to the field; developing a bioactive membrane intended to function two-fold: target diseased structures and transplant healthy RPE to the desired area.

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Section: Conclusion and Future Directionmentioning

confidence: 99%

Biomaterials Targeting AMD: Are We There Yet?

Lawless¹,

Hidalgo-Alvarez²,

Haneef³

2020

Preprint

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Assessing the Suitability of Electrospun Poly(Ethylene Terephthalate) and Polystyrene as Cell Carrier Substrates for Potential Subsequent Implantation as a Synthetic Bruch's Membrane

Haneef

Downes

2014

International Journal of Polymeric Materials and Polymeric Biom

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Electrospun poly(ethylene terephthalate) (PET) and polystyrene (PS) were tested for suitability as cell carrier substrates. Membranes were UV=ozone treated, which improved protein adsorption, with aminolysis observed on PET. PET demonstrated greater handling and durability compared to PS. Treated and untreated PET supported cell proliferation, with cells exhibiting the desired monolayer morphology. Untreated PS did not support cell proliferation and although treated PS did, the resultant RPE cell morphology was undesirable. Preliminary tests investigating thickness of mats were also undertaken, with PET exhibiting better results. Electrospun PET exhibited cytocompatibility, and could prove to be a suitable candidate for potential subsequent implantation.

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Controlling Fiber Morphology and Scaffold Design for Treatment of Dry Age-Related Macular Degeneration

Cited by 2 publications

References 22 publications

Biomaterials Targeting AMD: Are We There Yet?

Biomaterials Targeting AMD: Are We There Yet?

Assessing the Suitability of Electrospun Poly(Ethylene Terephthalate) and Polystyrene as Cell Carrier Substrates for Potential Subsequent Implantation as a Synthetic Bruch's Membrane

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