Controlling morphology of hydroxyapatite nanoparticles through hydrothermal microemulsion chemical synthesis

García, Carlos; García, Cristhian; Paucar, Carlos

doi:10.1016/j.inoche.2012.02.024

Cited by 32 publications

(14 citation statements)

References 15 publications

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“…An example of such a cosurfactant is a long-chain alcohol, which is also known to reduce the rigidity of water-in-oil interfaces [149]. García et al [210] studied the effect of cosurfactant (n-butanol) in a CTAB/toluene/water microemulsion system under hydrothermal conditions. They found that the cosurfactant to surfactant molar ratio also played an important role in controlling the morphology of HAp nanoparticles.…”

Section: Emulsion Methods (Surfactant-based Biphasic Process)mentioning

confidence: 99%

“…The HAp surface possesses hydroxyl groups and calcium and phosphate ionic sites that can react with several functional groups. For example, alkoxysilyl groups (silane coupling agents) [210,366] and isocyanate groups [367] can covalently react with surface hydroxyl groups of HAp, and carboxyl groups can interact ionically with calcium ions on the HAp surfaces. Polymer and metal substrates have been used [346][347][348][349][350][351][352][353][354][355].…”

Section: Nanocrystal Coatingmentioning

confidence: 99%

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Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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Hydroxylapatite (or hydroxyapatite, HAp) exhibits excellent biocompatibility with various kinds of cells and tissues, making it an ideal candidate for tissue engineering, orthopedic and dental applications. Nanosized materials offer improved performances compared with conventional materials due to their large surface-to-volume ratios. This review summarizes existing knowledge and recent progress in fabrication methods of nanosized (or nanostructured) HAp particles, as well as their recent applications in medical and dental fields. In section 1, we provide a brief overview of HAp and nanoparticles. In section 2, fabrication methods of HAp nanoparticles are described based on the particle formation mechanisms. Recent applications of HAp nanoparticles are summarized in section 3. The future perspectives in this active research area are given in section 4.

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Section: Emulsion Methods (Surfactant-based Biphasic Process)mentioning

confidence: 99%

Section: Nanocrystal Coatingmentioning

confidence: 99%

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Okada

Furuzono

2012

Science and Technology of Advanced Materials

126

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“…Meanwhile, the -PO 4 anions in HA site also possesses a tetrahedral structure. Hence, the CTAB is capable to regulate the crystallization process [30]. However, the CTAB does not prevent the formation of agglomerates upon mixing the sources of Ca and P. The energy dispersive spectroscopy (EDS) spectra evidence the presence of Ca, P and O in the HA samples prepared out of different anionic precursors as depicted in Fig.…”

Section: Morphological Analysismentioning

confidence: 99%

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Sundarabharathi¹,

Ponnamma

Parangusan

et al. 2019

SN Appl. Sci.

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Synthetic nano hydroxyapatites (HA) have been considered as potential biomaterials for bone tissue engineering applications because of its excellent biological properties. The present work deals with the synthesis of HA nanoparticles from different anion source materials via autoclave assisted hydrothermal method. All the prepared HA nanoparticles were characterized by X-ray diffraction (XRD), Fourier transformation infrared spectra, field emission scanning electron microscopy, energy dispersive spectra and high resolution transmission electron microscopy. The XRD patterns reveal the pure and hexagonal phase structure with smaller crystallite size for HA obtained from various calcium salt precursors. HA particles prepared from nitrate precursors show spherical morphology with 32 nm grain size whereas those derived from the acetate, chloride and egg shell precursors respectively show needle-like, irregular and oval morphology. The effect of different anions on the dielectric properties and alternating conductivity of HA is investigated, as a polarized surface can trigger biological reactions. For the particles obtained from nitrate, acetate, chloride and egg shell precursors respectively give dielectric constant (εʹ) values of 9.96, 13.22, 9.92 and 10.86 at 5 MHz. The εʹ and dielectric loss (εʹʹ) values for the HA nanoparticles decrease with increase in the applied frequency as well. The alternating current conductivity values confirm that the as-synthesized HA samples exhibit insulating behavior. In short this article provides the various applicability of HA particles in optoelectronics and drug delivery.

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“…Such a division depends on the complication of the synthesis system or difficulties on maintaining the synthesis conditions. Looking at the simplest approaches for nHAp synthesis—mostly one-step processes—one can extract as the most common wet chemical precipitation technique [ 9 – 11 ], hydrothermal method [ 12 , 13 ], sol-gel method [ 14 ], and microemulsion method [ 15 ]. In all of these methods, addition of templates, surfactants, or crystallization mediation agents is possible for improvement of product physical properties control.…”

Section: Introductionmentioning

confidence: 99%

Lecithin-based wet chemical precipitation of hydroxyapatite nanoparticles

2015

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Hydroxyapatite Ca10(PO4)6(OH)2 nanoparticles have been successfully synthesized by the wet chemical precipitation method at 60 °C in the presence of biocompatible natural surfactant—lecithin. The composition and morphology of nanoparticles of hydroxyapatite synthesized with lecithin (nHAp-PC) was studied by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Size distribution for nanoparticles was measured by nanoparticle tracking analysis in NanoSight system. We discuss in details influence of lecithin concentration in reaction system on nHAp-PC morphology, as well as on size distributions and suspendability of nanoparticles. Product exhibits crystalline structure and chemical composition of hydroxyapatite, with visible traces of lecithin. Difference in surfactant amounts results in changes in particles morphology and their average size.

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Controlling morphology of hydroxyapatite nanoparticles through hydrothermal microemulsion chemical synthesis

Cited by 32 publications

References 15 publications

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Hydroxylapatite nanoparticles: fabrication methods and medical applications

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

Lecithin-based wet chemical precipitation of hydroxyapatite nanoparticles

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