Controlling the release of peptide antimicrobial agents from surfaces

Shukla, Anita; Fleming, Kathleen; Chuang, Helen F.; Chau, Tanguy M.; Loose, Christopher; Stephanopoulos, Gregory; Hammond, Paula T.

doi:10.1016/j.biomaterials.2009.11.082

Cited by 251 publications

(222 citation statements)

References 50 publications

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“…This can be achieved by impregnating the surface with an antimicrobial agent or using functionalized coatings that allow a localized antimicrobial delivery (Zilberman and Elsner 2008; Shukla et al 2010;Yala et al 2011). As reviewed by Glinel et al (2012), several AMP-based coatings have been tested successfully.…”

Section: Anti-biofilm Antimicrobial Peptide Strategiesmentioning

confidence: 99%

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

2012

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Antimicrobial peptides (AMPs) have a broad spectrum of activity and unspecific mechanisms of action. Therefore, they are seen as valid alternatives to overcome clinically relevant biofilms and reduce the chance of acquired resistance. This paper reviews AMPs and anti-biofilm AMP-based strategies and discusses ongoing and future work. Recent studies report successful AMP-based prophylactic and therapeutic strategies, several databases catalogue AMP information and analysis tools, and novel bioinformatics tools are supporting AMP discovery and design. However, most AMP studies are performed with planktonic cultures, and most studies on sessile cells test AMPs on growing rather than mature biofilms. Promising preliminary synergistic studies have to be consubstantiated and the study of functionalized coatings with AMPs must be further explored. Standardized operating protocols, to enforce the repeatability and reproducibility of AMP anti-biofilm tests, and automated means of screening and processing the ever-expanding literature are still missing.

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Section: Anti-biofilm Antimicrobial Peptide Strategiesmentioning

confidence: 99%

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

2012

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“…These studies show that it is possible to incorporate and locally release AMPs while retaining antimicrobial activity, although broad-spectrum AMPs such as human lactoferrin 1-11 may not be as potent as conventional antibiotics such as gentamicin [44][45][46]. Shukla et al [47] incorporated a different AMP, ponericin G1, into a degradable polyectrolyte multilayer film that has applications as coatings for medical devices and wound healing. Controlled release over 10 d was achieved with tunable release profiles and retention of antimicrobial activity [47].…”

Section: Alternatives To Conventional Antibioticsmentioning

confidence: 99%

Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications

2013

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“…Furthermore, the same approach with PEM coatings could be applied to other biodegradable membranes and scaffolds, as we have described previously. Previous studies have demonstrated the compatibility of the poly(β-amino ester) family in vitro and in vivo (31,32). PAA is a well-characterized weak Data are means ± SEM (n = 5 implants per group).…”

Section: Discussionmentioning

confidence: 99%

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

Shah

Hyder

Quadir

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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131

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Traumatic wounds and congenital defects that require large-scale bone tissue repair have few successful clinical therapies, particularly for craniomaxillofacial defects. Although bioactive materials have demonstrated alternative approaches to tissue repair, an optimized materials system for reproducible, safe, and targeted repair remains elusive. We hypothesized that controlled, rapid bone formation in large, critical-size defects could be induced by simultaneously delivering multiple biological growth factors to the site of the wound. Here, we report an approach for bone repair using a polyelectrolye multilayer coating carrying as little as 200 ng of bone morphogenetic protein-2 and platelet-derived growth factor-BB that were eluted over readily adapted time scales to induce rapid bone repair. Based on electrostatic interactions between the polymer multilayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth factors in an easily tunable and controlled manner to direct endogenous cell function. To prove the role of this adaptive release system, we applied the polyelectrolyte coating on a well-studied biodegradable poly(lactic-co-glycolic acid) support membrane. The released growth factors directed cellular processes to induce bone repair in a critical-size rat calvaria model. The released growth factors promoted local bone formation that bridged a critical-size defect in the calvaria as early as 2 wk after implantation. Mature, mechanically competent bone regenerated the native calvaria form. Such an approach could be clinically useful and has significant benefits as a synthetic, off-the-shelf, cell-free option for bone tissue repair and restoration.regenerative medicine | layer-by-layer | biomaterial | controlled drug release | wound healing

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Controlling the release of peptide antimicrobial agents from surfaces

Cited by 251 publications

References 50 publications

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

New trends in peptide-based anti-biofilm strategies: a review of recent achievements and bioinformatic approaches

Perspectives on the prevention and treatment of infection for orthopedic tissue engineering applications

Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction

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