Controlling the Size of Taurine Crystals in the Cooling Crystallization Process

Lin, Ruohui; Woo, Meng Wai; Selomulya, Cordelia; Lu, Jianping; Chen, Xiao

doi:10.1021/ie4000807

Cited by 13 publications

(10 citation statements)

References 38 publications

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“…The operational conditions of spherical crystallization can influence the crystal morphology and particle size distribution. 33 Hence, the effect of three parameters including the stirring speed, the terminal temperature and the initial supersaturation of m-ABA solution were studied in our investigation. The operating conditions were listed in Table 1.…”

Section: Investigation Of the Effect Of Process Parametersmentioning

confidence: 99%

Spherical Agglomerates of m-Aminobenzoic Acid: Solvent Selection, Preparation, Mechanism, and Characterization

Xiao

Wang

Tuo

et al. 2021

Ind. Eng. Chem. Res.

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Solvents for spherical agglomerates preparation are usually selected according to the Lifshitz–van der Waals acid–base theory with negative adhesion free energies. However, some solvents with positive adhesion free energies in which spherical agglomerates can be obtained are easily ignored. This work proposes that solvents should be screened comprehensively by theoretical calculation combined with experiments using m-aminobenzoic acid (m-ABA) as a model compound. According to the Lifshitz–van der Waals acid–base theory, water, isopropyl alcohol, and ethylene glycol with negative adhesion free energies were screened out as the possible solvents for the preparation of m-ABA spherical agglomerates. Crystallization experiments showed that in addition to the three solvents, methanol and ethanol with positive adhesion free energies were also appropriate for spherical crystallization of m-ABA. A common feature of the five solvents which can form spherical agglomerates is that they have both hydrogen-bond-donating and hydrogen-bond-accepting capabilities. The single-factor analysis method was used to systematically investigate the effects of stirring speed, terminal temperature, and supersaturation on spherical agglomerates of m-ABA. The formation mechanism of m-ABA spherical agglomerates was elucidated with the help of the in situ Pixact Crystallization Monitoring system. Comparative experiments proved that the obtained spherical agglomerates exhibit better chemical stabilities and crystal form stability than needle-like crystals.

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Section: Investigation Of the Effect Of Process Parametersmentioning

confidence: 99%

Spherical Agglomerates of m-Aminobenzoic Acid: Solvent Selection, Preparation, Mechanism, and Characterization

Xiao

Wang

Tuo

et al. 2021

Ind. Eng. Chem. Res.

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“…As shown in Figure S5, the crystals obtained were almost all spherical crystals under the stirring speed investigated. When the stirring speed was increased from 100 to 500 rpm at an interval of 100 rpm, the average size decreased from 315 to 158 μm due to an increase in the shear force . However, the crystal size distribution became narrow gradually with the increasing of stirring speed which may be because better mixing at the higher stirring speed could avoid local supersaturation and inhibit the nucleation process.…”

Section: Resultsmentioning

confidence: 99%

“…When the stirring speed was increased from 100 to 500 rpm at an interval of 100 rpm, the average size decreased from 315 to 158 μm due to an increase in the shear force. 32 However, the crystal size distribution became narrow gradually with the increasing of stirring speed which may be because better mixing at the higher stirring speed could avoid local supersaturation and inhibit the nucleation process. Considering both average size and particle size distribution of the products, the stirring speed is set to 300 rpm.…”

Section: Resultsmentioning

confidence: 99%

Self-Assembly of Monodispersed Carnosine Spherical Crystals in a Reverse Antisolvent Crystallization Process

Zhou

Wang

et al. 2019

Crystal Growth & Design

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Spherical crystallization is an effective way to increase particle size, raise bulk density, and improve flowability and compressibility of crystals with small sizes, especially needle-like and flake-like microcrystals. In this work, a reverse antisolvent crystallization method was used to obtain the spherical crystals of carnosine instead of commercially available needle-like carnosine material. Besides, the solubility of carnosine in a binary solvent mixture of water + ethanol was measured at temperatures ranging from 288.05 to 323.15 K by using a gravimetric method under atmospheric pressure to optimize this crystallization process and increase the yield of carnosine. On the basis of these thermodynamic data, single factor analysis in a reverse antisolvent crystallization process was performed, including carnosine aqueous solution concentration, feeding rate, volume ratio of solution to antisolvent, temperature, and stirring speed. Polarizing microscopy, particle size distributions, and in situ particle vision measurements were used to characterize and monitor the carnosine spherical crystals during the reverse antisolvent crystallization process. Finally, monodispersed, several hundred micrometer-sized carnosine spherical crystals with a higher bulk density (0.224 g/mL) and smaller repose angle (39°), which indicated better flowability, were successfully crystallized, and a feasible formation mechanism was proposed.

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“…This may be because the stirring accelerates collisions between crystals and facilitates secondary nucleation in crystallization process, resulting in the formation of small crystals. [14][15][16][17] Moreover, the particle size distribution curves obtained by statistical treatments are shown in Figure 3. It can be found that as the stirring rate increases, the particle size distribution of the AP crystals becomes narrower.…”

Section: Batch Cooling Crystallizationmentioning

confidence: 99%

Solvent–Solvent Cooling Crystallization: An Effective Method to Control the Morphology and Size of Ammonium Perchlorate Crystals

Liu

Xie

et al. 2019

Crystal Research and Technology

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Controlling ammonium perchlorate crystals with desired properties is still a challenge in industrial crystallization. In this work, two different cooling crystallization methods, namely solvent–solvent cooling crystallization and batch cooling crystallization, are compared to prepare ammonium perchlorate crystals with tunable shapes and sizes. The influences of crystallization parameters such as cooling pattern, cooling rate, stirring rate, feed rate, and solution concentration on the morphology and size of ammonium perchlorate particles are studied. The results indicate that solvent–solvent cooling crystallization makes it easier to control the supersaturation of the crystallization system than bath cooling crystallization, resulting in a more uniform morphology of the ammonium perchlorate crystals prepared by the solvent–solvent cooling crystallization. In addition, by adjusting the crystallization conditions, the shape of ammonium perchlorate crystals can be tailored as long rectangle, tabular, spherical, platy, bipyramid, and high‐index faced polyhedron shaped, the mean size of which can be controlled from 43.9 to 191.9 µm. Moreover, the proposed crystallization method provides a promising strategy for the continuous production of ammonium perchlorate crystals in industry; it is also a reference for the crystallization of other materials in crystal engineering.

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Controlling the Size of Taurine Crystals in the Cooling Crystallization Process

Cited by 13 publications

References 38 publications

Spherical Agglomerates of m-Aminobenzoic Acid: Solvent Selection, Preparation, Mechanism, and Characterization

Spherical Agglomerates of m-Aminobenzoic Acid: Solvent Selection, Preparation, Mechanism, and Characterization

Self-Assembly of Monodispersed Carnosine Spherical Crystals in a Reverse Antisolvent Crystallization Process

Solvent–Solvent Cooling Crystallization: An Effective Method to Control the Morphology and Size of Ammonium Perchlorate Crystals

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