Controversial Practices in Allergy

Grieco, Michael H.

doi:10.1001/jama.1982.03320470052032

Cited by 42 publications

(2 citation statements)

References 34 publications

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“…The sublingual provocative food testing was not able to differentiate between placebo and food drops (42, 43, 44) and may even be potentially fatal in patients with systemic mastocytosis (45).…”

Section: Miscellaneousmentioning

confidence: 99%

Unproven diagnostic procedures in IgE‐mediated allergic diseases

Niggemann

Grüber

2004

Allergy

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A considerable body of literature on therapeutic aspects of complementary and alternative medicine has been published in recent years, but little is known on diagnostic procedures. This short review lists complementary and alternative diagnostic procedures for the diagnosis of allergic diseases and presents an assessment of their usefulness for the daily practice. The review of the literature revealed that neither the determination of specific immunoglobulin G‐antibodies in serum, the hair‐analysis, the cytotoxic test, kinesiology, iridology, or electrodermal testing represent useful tests for the daily practice. To date, no complementary or alternative diagnostic procedure can be recommended as a meaningful element in the diagnostic work‐up of allergic diseases. This is especially true for food allergy: properly performed oral food challenges still represent the gold standard for implementing specific diets in food allergic individuals. Ineffective diagnostic approaches may be costly for the consumer and delay appropriate therapy.

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Section: Miscellaneousmentioning

confidence: 99%

Unproven diagnostic procedures in IgE‐mediated allergic diseases

Niggemann

Grüber

2004

Allergy

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“…Many different tests and procedures have been proposed, but no single test or combination of tests has been validated as diagnostic. The tests most frequently used by practitioners who diagnose IEI are provocation-neutralization 11,[64][65][66][67][68] and a panel of immunologic tests. The latter encompasses measurements of serum immunoglobulins, complement levels, blood lymphocyte subset counts, autoantibodies, and serum antibodies to chemicals.…”

Section: Diagnostic Methodsmentioning

confidence: 99%

Idiopathic environmental intolerances

1999

Journal of Allergy and Clinical Immunology

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Elimination of Oral Food Challenge Reaction by Injection of Food Extracts: A Double-blind Evaluation

Rea¹,

Podell²,

Williams³

et al. 1984

Archives of Otolaryngology - Head and Neck Surgery

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\s=b\ Twenty subjects underwent a double-blind evaluation by analyzing six variables to determine if subcutaneous injection of the food extract neutralizing dose would protect subjects from reactions bo. Twelve subjects had four of the six variables neutralized 60% of the time following the food antigen neutralizing dose. The placebo trials neutralized four of six variables 15% of the time. The sign/ symptom results show statistical significance favoring food extract neutralization over placebo. The remaining eight subjects had at least two of the six variables neutralized by the food extract up to 85% of the time. It appears that the phenomenon of subcutaneous food neutralization can be scientifically endorsed for clinical use in the treatment of food reactions. (Arch Otolaryngol 1984;110:248-252) Intracutaneous injection therapy with food extracts by the method of symptom neutralization is a popu¬ lar, but controversial technique.14 Proponents of neutralization main¬ tain that if a person is sensitive to a substance, one often can determine through titration a specific dose of

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Controversial Practices in Allergy

Cited by 42 publications

References 34 publications

Unproven diagnostic procedures in IgE‐mediated allergic diseases

Unproven diagnostic procedures in IgE‐mediated allergic diseases

Idiopathic environmental intolerances

Elimination of Oral Food Challenge Reaction by Injection of Food Extracts: A Double-blind Evaluation

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