Controversies on Endocrine and Reproductive Effects of Glyphosate and Glyphosate-Based Herbicides: A Mini-Review

Araújo-Ramos, Anderson Tadeu de; Passoni, Marcella Tapias; Romano, Marco Aurélio; Romano, Renata Marino; Martino‐Andrade, Anderson Joel

doi:10.3389/fendo.2021.627210

Cited by 41 publications

(24 citation statements)

References 60 publications

(68 reference statements)

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“…Likewise, other studies have shown that exposure to GBH promotes a reduction in the activity of enzymes responsible for metabolizing cholesterol and forming steroid hormones in the testis of the animals (Pham et al, 2019; Romano et al, 2010). Likewise, in females, a reduction in the activity of aromatase is found, which converts testosterone into estradiol, promoting an increase in this adipose panicle (De Araujo‐Ramos et al, 2021; Ingaramo et al, 2020). In line with these studies, we found an increase in the adipose tissue in danger, the main supplier of cholesterol for the production of these hormones.…”

Section: Discussionmentioning

confidence: 99%

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Barbosa

Zazula

Oliveira

et al. 2022

The Anatomical Record

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Glyphosate (GBH) is a worldwide consumption pesticide and is used in the formulation of Roundup®, one of the most commercialized herbicides in the world. Maternal exposure to this herbicide can promote changes and adaptations in the offspring; however, the effects on skeletal muscle are poorly understood. In this sense, the present study sought to evaluate the effect of exposure to GBH on the characteristics of the soleus (SOL) and extensor digitorum longus (EDL) muscles. C57BL/6 pregnant female mice were divided into two groups: control (CTL) receiving water and glyphosate (GBH; n = 6) receiving 0.5% glyphosate. Male puppies were designated according to the group to which the mothers belonged, such as CTL‐F1 and GBH‐F1 and then euthanized at 150 days of age. There was a reduction in body weight and nasoanal length of animals exposed to GBH, while there was an increase in EDL weight, reduction in the proportion of fibers and number of nuclei, and an increase in the connective tissue of the SOL. The animals exposed to GBH presented higher values of body characteristics, mainly adiposity gain, while they presented a reduction in neuromuscular junctions (NMJ), and an increase in fibrosis in the SOL muscle, while there was a reduction in the number of nuclei, and an increase in the weight of the EDL muscle. These findings indicate that glyphosate can promote changes in the offspring's body growth, the deposition of adipose panicles and its effects on muscle can lead to changes in the structure and functioning of this tissue.

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Section: Discussionmentioning

confidence: 99%

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Barbosa

Zazula

Oliveira

et al. 2022

The Anatomical Record

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“…Certain groups of pesticides have the ability to modify the balance and function of the endocrine, immune, and neurological system (Cremonese et al, 2012;Pinheiro and Souza, 2017;de Araújo-Ramos et al, 2021). Therefore, fetal susceptibility to environmental exposure is even more critical if contact with these substances occurs early in the prenatal period, with risk of prematurity, low birth weight, reduced weight for gestational age, intrauterine growth retardation, reduced height and head circumference of the neonate, fetal death, poor Apgar score, and congenital malformations (CM), such as cryptorchidism and hypospadias (Cremonese et al, 2012;Carmichael et al, 2016;Froes Asmus et al, 2017;Ling et al, 2018;Toichuev et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Characterization and distribution of pesticide use from 2015 to 2019, by health regions in the state of Rondônia (RO), Amazon, Brazil

Franco

Parmejiani

Cunha

et al. 2021

Rev. Bras. Ciênc. Ambient.

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Colonization projects and the consolidation of commodities production made ranching and agriculture one of the main economic activities in Rondônia (RO). Simultaneously to this process, there was an increase in the consumption of pesticides, resulting in risks to human health and the environment. Based on datasets of different origins, this article analyzed the spatial distribution of pesticide commercialization in the different health regions of the state of Rondônia (RO), between 2015 and 2019. We used data from the Rondônia State Pesticide Trade Inspection System (Sistema de Fiscalização do Comércio de Agrotóxicos do Estado de Rondônia – SIAFRO), managed by the Agrosilvopastoral Health Defense Agency of the State of Rondônia (Agência de Defesa Sanitária Agrosilvopastoril do Estado de Rondônia – IDARON); the Phytosanitary Pesticides System (Sistema de Agrotóxicos Fitossanitários – AGROFIT), the National Health Surveillance Agency (Agência Nacional de Vigilância Sanitária – ANVISA), the Brazilian Institue of the Environment and Renewable Natural Resources (Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis – IBAMA) and of the IBGE Automatic Recovery System of the Brazilian Institute of Geography and Statistics (Sistema IBGE de Recuperação Automática do Instituto Brasileiro de Geografia e Estatística – SIDRA/IBGE). The consolidation of these data contributed to the analysis and presentation of the spatial distribution of the average amount of pesticides sold by health regions in RO and the main active ingredients sold, their use classification and quantity applied to each culture. We conclude that the production of commodities such as soy, corn, coffee, and pasture are the main drivers of pesticide commercialization in the study region. The main marketed active ingredients suggest potential risks to public health and the environment. In addition, the present safety criteria regarding pesticides, especially in Brazil, are outdated and lead to public health and environmental vulnerability.

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“…Usually, formulants have more deleterious effects than glyphosate alone because of possible cumulative effects on endocrine and reproductive endpoints [106]. As summarized in Table 1, in female reproduction, glyphosate and GBHs exposure has consequences for post-natal ovarian and uterine development, puberty onset, oocyte maturation, sperm-oocyte binding ability and early embryo development, implantation and successful pregnancy.…”

Section: Gbhs In Roundup Formulationsmentioning

confidence: 99%

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development

Marino

Mele

Viggiano

et al. 2021

IJMS

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Glyphosate is widely used worldwide as a potent herbicide. Due to its ubiquitous use, it is detectable in air, water and foodstuffs and can accumulate in human biological fluids and tissues representing a severe human health risk. In plants, glyphosate acts as an inhibitor of the shikimate pathway, which is absent in vertebrates. Due to this, international scientific authorities have long-considered glyphosate as a compound that has no or weak toxicity in humans. However, increasing evidence has highlighted the toxicity of glyphosate and its formulations in animals and human cells and tissues. Thus, despite the extension of the authorization of the use of glyphosate in Europe until 2022, several countries have begun to take precautionary measures to reduce its diffusion. Glyphosate has been detected in urine, blood and maternal milk and has been found to induce the generation of reactive oxygen species (ROS) and several cytotoxic and genotoxic effects in vitro and in animal models directly or indirectly through its metabolite, aminomethylphosphonic acid (AMPA). This review aims to summarize the more relevant findings on the biological effects and underlying molecular mechanisms of glyphosate, with a particular focus on glyphosate's potential to induce inflammation, DNA damage and alterations in gene expression profiles as well as adverse effects on reproduction and development.

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Controversies on Endocrine and Reproductive Effects of Glyphosate and Glyphosate-Based Herbicides: A Mini-Review

Cited by 41 publications

References 60 publications

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Characterization and distribution of pesticide use from 2015 to 2019, by health regions in the state of Rondônia (RO), Amazon, Brazil

Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development

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