Controversies on Preeclampsia through the lens of Reproductive Immunology: A Systematic Review

Ahmadi, Seyyed Amir Yasin; Shahsavar, Farhad; Hasanvand, Afshin

doi:10.16965/ijims.2016.104

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…Uterine vascular remodeling is one of the controversial issues in histology and embryology that approximately in all related articles it is known as an unknown process. So the final accepted idea in most papers like Ashton et al (31) is that for sufficient blood supplying of embryo it is necessary that uterine arteries should "revert", in which its endothelial cells are replaced by extra villous trophoblast (EVT), surrounding smooth muscles and fibrinoid (Figure 1), (29,(31)(32)(33). In the first trimester of pregnancy, decidual spiral arteries change from narrow position into dilated form with lack of maternal vasomotor control.…”

Section: Vascular Remodeling and Histopathology Of Endometriummentioning

confidence: 99%

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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IntroductionAmong the controversies in reproduction science, role of immune and inflammatory systems in implantation process and durability of pregnancy is a hot topic nowadays. Some researchers and practitioners believe that administration of drugs such as prednisolone, aspirin or heparin can improve success rate of implantation and pregnancy through inhibiting coagulation, inflammatory and immune systems; while others believe that such systems not only do not have negative effect on rejecting blastocyst and embryo by itself but also are necessary for implantation and remodeling of uterine spiral arteries through secreting adhesive and angiogenic factors. Such controversies are proposed both in natural pregnancies resulting in spontaneous abortion as well as in successful and/or unsuccessful assisted reproductive technologies (ARTs). Recurrent spontaneous abortion (RSA) is defined as having 3 or more history of abortion (1). About the other issue, some researchers and practitioners are grumbling of low success rate of ARTs like in vitro fertilization (IVF). Infertility is a problem for 10%-15% of couples; most of which -but not all -require ART (2). The average fertilization rate of ART in previous researches has been reported about 30% (3) and this report is for 1998. It has been claimed in an article published in 2015 that this rate has improved in the recent decade (4). Even though at the first glance this rate seems low, but the interesting point is that in the claim of a valid reference (5) the chance of natural pregnancy for each intercourse per month does not go up more than 33%. Also this number has been reported in some studies up to 40% (6). Thus, we should not be grumbling of the low fertilization rate of ARTs. Finally we intend to represent and report our insights, reasoning and suggestions in the present review. MethodsThis systematic and critical review includes investigation of scientific data bases and tracing the citations and the references of the articles in order to find the root of the truth. Through this wisdom, we showed the mere that a content proposed in an indexed article is not a reason that this content is valid and able to be cited. Indeed, the researcher should regard and notice the reasoning, citations and protocol of his/her references during the literature review. This is the benefit point of systematic review rather than holistic and narrative reviews. Since some data were few, the time period of publications was not important to us. As the searching strategy, we used the Web of Science Core Collection and Google Scholar for finding articles other than ISI-WOS and the tracing mentioned in the above paragraph. Results and DiscussionRole of Immune System and Leukocytes In 2015, Ghafourian et al (1) by measuring the level of natural killer-cells (NKs) in blood of the RSA and the control group concluded that RSA patients in normal (non-preg- AbstractAmong the controversies about reproduction sciences, role of immune and inflammatory systems in implantation process and durability of...

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Section: Vascular Remodeling and Histopathology Of Endometriummentioning

confidence: 99%

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017

Vincent

Darmayasa

Suardika

2018

Intisari Sains Medis

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Background: Preeclampsia and eclampsia have been increasing at an alarming rate. It is a challenging task for doctors and pregnant mothers. Preeclampsia defined as new onset of hypertension (≥140mmHg systolic or ≥90mm Hg diastolic on at least two occasions 6 hours apart) and proteinuria (at least 1+ on dipstick or ≥300mg in a 24-hour urine collection) after 20 weeks of gestation. Eclampsia defined as neurologic involvement in the form of generalized tonicclonic convulsions in women with preeclampsia is termed eclampsia if the seizures cannot be attributed to any other cause such as epilepsy, cerebral infection, tumor or ruptured aneurysm. Aim: This study aims to find the association of risk factors for preeclampsia and eclampsia. The risk factors for preeclampsia and eclampsia are obesity, primigravida, multiple pregnancies, diabetes, pre-existing hypertension, family history, expecting mother's age, nutritional status, and socioeconomic status. The study was carried out by using descriptive research and data were collected from medical records in Sanglah hospital which has 140 cases. Results: The results for preeclampsia are highest in expecting the age of 20-35 years old, primigravida women with gestational age > 37 weeks, overweight and overnourished women, a middle socioeconomic status and also without risk factors. The results for eclampsia are dominant in expecting age of 20-35 years old, primigravida women with gestational age > 37 weeks, women with middle socioeconomic status and majority without risk factors, and women who are overweight and overnourished. Conclusion: Preeclampsia and eclampsia cases are highest in expecting age of 20-35 years old, primigravida women with gestational age >37 weeks, overweight and overnourished women, majority women without risk factors and from middle socioeconomic status.

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Controversies on Preeclampsia through the lens of Reproductive Immunology: A Systematic Review

Abstract: BACKGROUND

Cited by 2 publications

References 18 publications

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017

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