2015
DOI: 10.1097/wnp.0000000000000150
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Conundrums of High-Frequency Oscillations (80–800 Hz) in the Epileptic Brain

Abstract: Pathological HFOs (80-800 Hz) are considered biomarkers of epileptogenic tissue, but the underlying complex neuronal events are not well understood. Here, we identify and discuss several outstanding issues or conundrums in regards to the recording, analysis and interpretation of HFOs in the epileptic brain to critically highlight what is known and what is not about these enigmatic events. HFOs reflect a range of neuronal processes contributing to overlapping frequencies from the lower 80 Hz to the very fast sp… Show more

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Cited by 53 publications
(54 citation statements)
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References 157 publications
(225 reference statements)
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“…Further improvements of HFOs signal quality rely on improvements in EEG acquisition [41,42]. Recording in a shielded environment and utilization of specialized hardware amplifiers can improve signal-to-noise ratio and improve the performance of HFOs detectors [33].…”
Section: Hfos Detectionmentioning
confidence: 99%
See 2 more Smart Citations
“…Further improvements of HFOs signal quality rely on improvements in EEG acquisition [41,42]. Recording in a shielded environment and utilization of specialized hardware amplifiers can improve signal-to-noise ratio and improve the performance of HFOs detectors [33].…”
Section: Hfos Detectionmentioning
confidence: 99%
“…While early studies were focused on the frequency band of the HFOs oscillations to classify them as pathologic or physiologic, considering the wide range of overlapping pHFOs and nHFOs frequencies [3,4,11,18,4244], more recent studies have explored other frequency-independent characteristics of HFOs: rate, amplitude, and duration [4552]. Regions showing a high rate of interictal HFOs have been correlated with pathological epileptic tissue in different studies [2,15,48,5254].…”
Section: Hfos Rate Amplitude and Durationmentioning
confidence: 99%
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“…First, referential montage increases the spatial resolution of the iEEG as compared with bipolar montage by increasing the total number of recordings. Second, referential montage could improve HFO detection by increasing the signal to noise ratio, since the dipole generators of the HFO could be distributed across multiple macro-electrode sites, which could obscure the HFO due to in phase cancellation (de la Prida et al, 2016). …”
Section: Introductionmentioning
confidence: 99%
“…A distinção entre HFO fisiológicas normais e HFO epileptiformes patológicas permanece um desafio para epileptologia clínica [77]- [79]. Uma abordagem simples é classificar HFO associadas com sharp waves epileptiformes como HFO patológicas e HFO evento-relacionadas a tarefas motoras e de memória como normais [80].…”
Section: Hfo Patológicas E Fisiológicasunclassified