Convalescent plasma: A potential therapeutic option for COVID-19 patients

The global pandemic of the coronavirus disease 2019 is a known consequence of infection of severe respiratory syndrome coronavirus-2 (SARS-CoV-2). It has affected nations worldwide with soaring number of cases daily. Symptoms such as fever, cough, and shortness of breath, diarrhea, nausea and vomiting are commonly presented in COVID-19 patients. This focused review aims to discuss these uncommon and atypical COVID-19 symptoms that may be presented which might affect neurological, cardiovascular, cutaneous and ocular systems and their possible mode of actions. Nonetheless, there are some cases of reported uncommon or atypical symptoms which may warrant healthcare professionals to be aware of, especially when in contact with patients. The knowledge and information concerning these symptoms might be able to provide additional cues for healthcare professional by subjecting patients to COVID-19 screening. Meanwhile, it might be able to further enhance the alertness and additional precautions being taken by healthcare personnel, which eventually lead to reduced risk of infections.

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Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening

Ong

Khaw

et al. 2021

Medicina

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Biopharmaceuticals for prevention of COVID-19

Akbarzadehlaleh¹,

Farjami²,

Montazersaheb³

et al. 2022

Asian Pacific Journal of Tropical Medicine

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The COVID-19 epidemic caused by SARS-CoV-2 virus has turned into a worldwide pandemic. Therefore, health officials all around the world have strived for developing efficient preventive and treatment methods to deal with this global crisis. Amongst them, monoclonal antibodies, anti-TNFs, and convalescent plasma appear to be effective against this disease. In addition, clinical trials are currently being conducted for viral targeting vaccines. This review summarizes major advances using biopharmaceuticals in the treatment and prevention strategies against COVID-19 that have occurred in the global medicinal system from its introduction until March 2022.

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Dynamics of transmission of COVID-19 cases and household contacts

Rajmohan

Jose

Thodi

et al. 2021

Journal of Acute Disease

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Objective: To study the transmission dynamics of coronavirus disease 2019 (COVID-19) among 101 confirmed cases and their 387 household contacts and to determine risk factors associated with secondary attack among the household contacts. Methods: A prospective cohort study was conducted from January 1st 2021 to February 28th 2021, among 101 SARS-CoV-2 cases and 387 household contacts who were followed up for 14 days from the last day of contact with the index case of COVID-19. The dynamics of disease transmission was estimated, and factors affecting transmission risk were analyzed. Besides, the association between various factors and household secondary attack rate was determined. Results: The median incubation period was found to be 5 days, and the observed reproductive number (R) was found to be 1.63 (95% CI: 1.28-1.98). The mean household secondary attack rate was 40.7%. Contacts with comorbidities like diabetes mellitus, hypertension, dyslipidemia, and hypothyroidism had significantly higher attack rates (P<0.05). Conclusions: As new variants of SARS-CoV-2 emerges, it is crucial to know the trasmission dynamics. This study shows a high secondary attack rate of COVID-19 among household contacts that must be closely monitored.

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Convalescent plasma: A potential therapeutic option for COVID-19 patients

Cited by 3 publications

References 19 publications

Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening

Focused Review: Potential Rare and Atypical Symptoms as Indicator for Targeted COVID-19 Screening

Biopharmaceuticals for prevention of COVID-19

Dynamics of transmission of COVID-19 cases and household contacts

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