Convenient and sequential one-pot route for synthesis of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives

CuBr‐catalysed one‐pot multicomponent synthesis of 3‐substituted 2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives

“…White solid; m.p. 245–246°C (247–248°C), IR (KBr, ν , cm −1 ): 3178, 3029, 1694, 1645, 1621, 1533, 1486. 1 H NMR (500 MHz, DMSO‐ d 6 , δ , ppm): 5.24 (s, 2H), 7.19–7.27 (m, 7H), 7.74–781 (m, 2H), 12.01 (brs, 1H).…”

“…White crystals; m.p. 262–264°C (265–268°C). IR (KBr, ν , cm −1 ): 3268, 3071, 1664, 1623, 1596, 1532, 1481.…”

“…Extending the chemistry of quinazolinone and its derivatives and the use of copper as catalyst in the reactions have been a goal of our research group. Following our ongoing efforts for the synthesis of quinazolinone derivatives, herein we report a method for the synthesis of 3‐substituted 2‐thioxo‐2,3‐dihydroquinazolin‐4(1 H )‐one derivatives based on a tandem reaction through the reaction of methyl 2‐bromobenzoate, phenylisothiocyanate and sodium azide in the presence of copper bromide and l ‐proline (Scheme ).…”

Facile Non‐Transition Metal‐Catalyzed Synthesis of 2‐Thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one Derivatives via One‐Pot Multicomponent Reactions

“…Following our ongoing efforts for the synthesis of quinazolinone derivatives, we hereby, report a method for the synthesis of 3‐alkyl/aryl‐2‐thioxo‐2,3‐dihydroquinazolin‐4(1 H )‐one derivatives . The products are obtained from the multicomponent reaction of isatoic anhydride, aniline and amine derivatives, chloroform and sulfur in the presence of potassium tert ‐butoxide (Scheme ).…”

Synthesis of Novel 6‐Mercapto‐12‐phenethyl‐quinazolino[3,4‐a]quinazolinones

“…One of the versatile methods for the preparation of quinazlinone derivatives is based on the isatoic anhydride as a useful starting material . At this juncture, we have successfully developed efficient procedures for the synthesis of a wide range of derivatives of quinazolinone and significant results encouraged us to continue our research into the new quinazolinones (Scheme ). Herein, based on the anticancer activity of quinazolines and our experience in this field , we synthesized novel 6‐mercapto‐12‐phenethyl‐quinazolino[3,4‐ a ]quinazolinone derivatives 9 .…”