Synthesis of Novel 6‐Mercapto‐12‐phenethyl‐quinazolino[3,4‐a]quinazolinones

Abstract

Novel 6‐mercapto‐12‐phenethyl‐quinazolino[3,4‐a]quinazolinone derivatives were synthesized through a user‐friendly five‐step reaction starting from isatoic anhydride. All products were characterized by IR, 1H‐NMR, 13C‐NMR spectroscopy, and chemical analysis. All of them were evaluated for their in vitro cytotoxic activity against two cell lines namely MOLT‐4 (human lymphoblastic leukemia) and MCF‐7 (human breast adenocarcinoma).

Synthesis of Cytotoxic Isodeoxypodophyllotoxin Analogs

“…Interestingly, Zavala et al have reported that isodeoxypodophyllotoxin ( 7a ) with 5,5a‐ trans ‐5a,8a‐ trans configuration has equipotent inhibition against microtubule assembly in comparison to podophyllotoxin (bearing a 5,5a‐ cis ‐5a,8a‐ trans configuration) . In continuation of our work on heterocyclic compounds , we describe here the synthesis and cytotoxic activity of isodeoxypodophyllotoxin derivatives with focusing on the modification of E ring (Fig. ).…”