Convenient Synthesis and Antibacterial Activity of Tricyclic Azine Derivatives

Abstract

Phenylenediamine reacted readily with 2 mol of ethyl acetoacetate to give diethyl (2Z,2'Z)-3,3'- [(1,4-phenylene)bisimino]dibut-2-enoate, which reacted with dimethylformamide dimethylacetal, activated methylene nitriles, ylidenemalononitriles and phenyl and benzoyl isothiocyanate to give, respectively, a 4,7-phenanthroline-2,9-dicarboxylate-1,10-diol, and tricyclic bispyridine and bispyrimidine derivatives. Two compounds showed strong antibacterial activity against several microorganisms, while six others showed high to moderate activity.

Chelating Behaviour of Dihydrothieno[3,4, d] Pyridazine Derivatives with Some Lanthanide and Actinide Metals

“…Furthermore, a number of thienopyridazines have been claimed to possess interesting biological and pharmacological activities such as, anticancer 16 , useful as oxidase inhibitor [17][18] . Complexation of thienopyridazine with transition and rare earth metals have been studied [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] .…”