Synthesis of novel 9-((arylidene)hydrazono)-2,4,6,8-tetrakis(4-methoxyphenyl)-3,7-diazabicyclo[3.3.1]nonane azines as potential antibacterial agents

Antibacterial Activity Exerted by some Diazabicyclo-steroid Derivatives Against Staphylococcus Aureus and Streptococcus Pneumoniae

“…There are reports which indicate the preparation of diazahicyclo derivatives as antibacterial agents; nevertheless, expensive reagents and special conditions are required [9][10][11][12][13][14][15][16][17] . Therefore, in this study three diazahicyclo-steroid derivatives were synthetized using several strategies to evaluate the biological activity against Staphylococcus aureus and Streptococcus pneumoniae.…”

“…In this sense, new drugs have been developed for control of bacterial resistance; for example, the preparation of diazabicycle derivatives as antibacterial agents against Staphylococcus aureus strains 9 Other data in dicate the synthesis and antibacterial activity of some 1,3-diazabicyclo-carbapen derivatives 2,4-dichloro-5-fluorophenyl derivatives against Staphylococcus aureus strain 10 . In addition, some 3, 7-diazabicyclo[3.3.1]nonaneazines were prepared as antibacterial agents against Staphylococcus aureus 11 . In addition a study showed the synthesis of 9-alkyl-l,5-diazabicyclo-[4.3.0]non-5-enes which decreased the bacterial growth of Staphylococcus aureus 12 .…”

Synthesis of diversely substituted adamantanes as a new class of antimicrobial agent

“…Though the synthesis of 4,8,9,10-tetraaryl-1,3-diazatricyclo[3.3.1.1]decan-6-ones and its corresponding alcohols have been reported [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] for a limited number of derivatives, their biological significance is not yet explored and hence in the present work 4,8,9,10-tetraaryl-1,3-diazatricyclo[3.3.1.1]decan-6-ones were synthesized using the reports available in the literature [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], which in turn reduced into 4,8,9,10-tetraaryl-1,3-diazatricyclo[3.3.1.1]decan-6-ols using NaBH 4 ; characterized using IR, 1 H NMR, 13 C NMR, and mass spectral data and then subjected to antimicrobial evaluation against various microbial strains and the results were discussed.…”