Convenient Synthesis of Ferrocene Conjugates Mediated by Benzyltriethylammonium Tetrathiomolybdate in a Multi‐Step Tandem Process

Abstract

The synthesis of a wide range of ferrocene‐derived sulfur‐linked mono‐ and disubstituted Michael adducts and conjugates mediated by benzyltriethylammonium tetrathiomolybdate (1) in a tandem process is reported. New route to access acryloylferrocene (4) and 1,1′‐diacryloylferrocene (5) is discussed. Conjugation of amino acids to ferrocene is established via their N and C termini and also via side chains employing conjugate addition as key step to furnish mono‐ and divalent conjugates. This methodology has also been extended to access several ferrocene–carbohydrate conjugates. The electrochemical behavior of some selected ferrocene conjugates was studied by cyclic voltammetry. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

The synthesis, structure, electrochemistry and in vitro anticancer activity studies of ferrocenyl-thymine conjugates

“…These reactions afforded the expected chloroketones 11a and 12a both with 70% isolated yield. In a second step, 11a and 12a were treated with triethylamine in CH 3 CN solution for 15 min [40]. These dehydrohalogenation reactions allowed us to obtain acryloyl derivatives 11b and 12b with 90% and 93% yields respectively.…”

Convenient Synthesis of Ferrocene Conjugates Mediated by Benzyltriethylammonium Tetrathiomolybdate in a Multi‐Step Tandem Process

“…In the original article 1 the structures of the anomeric bromides 22 – 25 have been wrongly indicated as β‐anomers; all of them ( 22 – 25 ) have to be α‐anomeric bromides, which upon reaction with tetrathiomolybdate furnish β‐substituted ferrocene conjugates.…”