Synthesis of ferrocene derivatives functionalized with α-methylene-γ-butyrolactone rings

Recent advances in the synthesis of ferrocene derivatives via 3d transition metal-catalyzed C–H functionalization

“…7 The other strategy involves direct functionalization of the ferrocene backbone. This strategy is mainly carried out by a Friedel–Crafts type electrophilic aromatic substitution reaction 8 or by a lithiation reaction employing stoichiometric alkyllithium reagents followed by a reaction with electrophiles. 9 This lithiation method has proven to be useful especially for the preparation of various 1,2-disubstituted ferrocene-based chiral ligands when chiral auxiliaries or chiral ligands were employed.…”