Conventional, continuous, and telemetric monitoring of urodynamic parameters in non‐human primates: A comparative study

Ghoniem, Gamal M.; Sakr, Mostafa A.; Shabaan, Alaa M.; Shoukry, Mohamed; Aertker, Mike W.

doi:10.1002/(sici)1520-6777(1996)15:3<203::aid-nau5>3.3.co;2-n

Cited by 3 publications

(3 citation statements)

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“…Urge sensations generally disappear on voiding. Because of our initial results, which are in line with those studies using comparative ambulatory pressure monitoring, we are convinced that conventional cystometry does not reveal the real clinical situation in the majority of patients [11,[65][66][67]. Accordingly, the less time-consuming comparative cystometry is recommended, so as to include former underdiagnosed 'normals' as well as former undiscovered urge incontinence.…”

Section: Diagnosissupporting

confidence: 72%

Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence

Hohlbrugger

1996

Int Urogynecol J

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Urine contains up to 10 times more potassium (K+) than blood plasma. Hence, extracellular K+ concentration of the bladder wall can increase secondary to a leaky urothelium (GAG layer deficiency) and/or vesical ischemia (reduced washout) at low filling volumes. Consequent sensory afferentiated excitation/depolarization of the detrusor leads to urgency/frequency and facilitates the onset of 'uninhibited' contractions. This feature, in association with a weak rhabdosphincter, causes urge incontinence. The non-neuromuscular (non-reflexive) origin explains refractoriness to any neurotransmitted inhibition. Even successful interference with contractility (Ca2+) leaves depolarization unaffected. Accordingly, comparative cystometry (saline versus 0.2 M KCl) is recommended in order to comprise better former falsely under-diagnosed 'normals' as well as former undiscovered urge incontinence, and thus indications for bladder neck surgery as well as neuromuscular drug treatment. Future first-line therapy in idiopathic storage disorders should be directed to the GAG layer, vesical blood flow (K+ washout) and the rhabdosphincter.

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Section: Diagnosissupporting

confidence: 72%

Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence

Hohlbrugger

1996

Int Urogynecol J

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“…Urodynamic studies in non-human primates (rhesus monkeys) showed that telemetric and continuous monitoring of detrusor pressure is more physiological and more accurate than conventional urodynamics [14]. They were able to show that, at 6-8 weeks after implantation, investigated variables (frequency, volume, maximum flow rate [Q max] , maximum detrusor pressure [P det max ]) approached the values before implantation [15]. Ghoniem et al [14] were among the first researchers to generate physiological telemetric data using the combination of telemetry and uroflowmetry.…”

Section: Introductionmentioning

confidence: 99%

Telemetric monitoring of bladder function in female Göttingen minipigs

Huppertz

Kirschner‐Hermanns²,

Tolba

et al. 2015

BJU Int

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These authors contributed equally to this work. ObjectivesTo generate real-time radio-telemetric urodynamic reference data of maximum detrusor pressure (P det max ), maximum flow rate (Q max) and estimated grade of infravesical obstruction, as well as duration of detrusor contraction (DOC), in female G€ ottingen minipigs and to describe translational aspects of the use of G€ ottingen minipigs for urological research. Materials and MethodsA telemetric transmitter was implanted into five female G€ ottingen minipigs, and 24 h measurements in metabolic cages were taken. Through operator-based analysis, synchronized real-time radio-telemetric cystometric data with flowmetric data and video sequences were used to determine voiding detrusor contractions (VCs) and non-voiding detrusor contractions (NVCs). Furthermore, data from telemetric natural-filling cystometry from free-moving and restricted maintenance conditions were compared for potential differences. ResultsThe median (range) P det max of VCs was 120.6 (21.0-370.0) cmH 2 O and, therefore, significantly different from that of .6 cmH 2 O] cm H 2 O). Intraindividual comparison of minipig data revealed great differences in voiding contractions. The effects of limited movement on VCs were analysed and showed significantly higher P det max and lower DOC than in free-moving conditions. ConclusionThe presented data can be used for the development of telecystometric implanted minipig models, to investigate changes of detrusor function such as under-or overactivity, and might serve as model for bladder changes occurring with iatrogenic bladder outlet obstruction (BOO) or different therapeutic options for overactive bladder. Radio-telemetric real-time natural filling and voiding cystometries are feasible, reproducible in non-anaesthetized minipigs with free or limited movement and can give new insights into circadian behaviour and physiological and pathological bladder function.

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“…Ghoniem et al demonstrated that telemetric and continuous bladder pressure monitoring in primates was more physiological and more accurate than conventional UDS. 10 In the minipig radiotelemetric ambulatory filling and voiding cystometry is a useful translational model of voiding function. 11 Animal models are helpful to develop new treatments for pelvic floor dysfunction.…”

mentioning

confidence: 99%

Conscious Neuromodulation of the Bladder before Clinical Use

Comiter

2015

Journal of Urology

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Conventional, continuous, and telemetric monitoring of urodynamic parameters in non‐human primates: A comparative study

Cited by 3 publications

References 0 publications

Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence

Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence

Telemetric monitoring of bladder function in female Göttingen minipigs

Conscious Neuromodulation of the Bladder before Clinical Use

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