Conventional or mechanochemically-aided intercalation of diclofenac and naproxen anions into the interlamellar space of CaFe-layered double hydroxides and their application as dermal drug delivery systems

Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications

“…LDHs are well-known anion exchanging materials [36] and have numerous applications in different areas such as electrochemistry [37], drug delivery [38] or heterogeneous catalysis [39,40] due to their several advantages such as ease of preparation [41], chemical stability [42], resistance against mechanical energy [43] and compatibility with biological systems [44]. By utilizing their anion exchanger capacities, various structures of different interlayer galleries or outer surfaces, morphologies [45,46], dimensions [47] and compositions [48] were produced, exhibiting wider physicochemical properties compared to their parent structures.…”

Nickel Hydroxides: Requirements, Targeted Construction and Choice of Characteristics and Industrially Applicable Synthesis for Targeted Use in Electrochemical Devices

“…[95,96] However, there are synthesis methods that are specific only to layered double hydroxides. These methods include the reconstruction method, [97] based on the fact that LDHs have a memory effect. If LDH is slowly heated and calcined at a certain temperature, layered double hydroxide (LDH) turns into layered double oxide (LDO).…”

Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging

“…By synthetically manipulating the content and structure of the LDH, it may be possible to produce bio-applicable intercalating moieties between the layers for various biomedical applications. Several chemical methods such as coprecipitation [ 1 , 2 , 33 , 34 , 35 , 36 ], ion exchange [ 3 , 37 , 38 , 39 ], exfoliation-reassembling [ 39 , 40 , 41 ], and calcination–reconstruction [ 10 , 35 , 42 , 43 , 44 , 45 ] can be used for lattice engineering to prepare biofunctional LDH nanohybrid materials, as shown in Figure 3 [ 46 , 47 ]. The guest species are accommodated within the interlayers of LDHs through electrostatic interactions, hydrogen-bonding linkages, and van der Waals forces between the guest species and the hydroxyl groups of LDH layers, as well as interlayer anionic and water molecules [ 21 , 30 ].…”

“…Sipos et al used several synthetic approaches to intercalate naproxen or diclofenac, nonsteroidal anti-inflammatory medicines, into the interlamellar area of CaFe-LDH for cutaneous administration [ 45 ]. Based on the highest organic content and average crystal thickness, the dehydroxylation-rehydration approach was the most suited for drug-LDH composites among coprecipitation, direct anion exchange, dehydroxylation-rehydration, and mechanochemical treatment.…”