Conventional pap (papanicoloau) smear cytology in primary screening of cervical lesions &amp; its comparison with manual liquid based cytology

Garg, Vibhuti; Thakral, Rajender Kumar; Sharma, Veena; Agarwal, Anil; Gupta, Kamna; Vedi, Apurva

doi:10.5958/2394-6792.2016.00090.9

Cited by 2 publications

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“…We compared the parameters we had derived from our study with some standard studies and analysed it statistically. In the present study the most common age group that have undergone the testing was 4 th decade which is comparable with Hawaldar [29] and Sherwani [10] whereas the study by Garg [27] showed less than 30 years age group as the most common ( Table-4). The most common clinical presentation of discharge PV (46%) was comparable with the studies by Garg and Sherwani ( Table-5).…”

Section: Original Research Articlesupporting

confidence: 85%

“…A decline in the incidence and mortality caused by cervical cancer has been observed in the past few decades as a result of screening by cytology. In recent years, the accuracy of the conventional Pap smear has come under a great deal of scrutiny [27]. Liquid-based cytology (LBC) was introduced in mid-1990s as an alternative technique to process cervical samples.…”

Section: Discussionmentioning

confidence: 99%

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Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Sankar

Selvi

Lenin

et al. 2019

Trop J Pathol Microbiol

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Introduction: Cervical cancer is the second most common cancer among Indian women and the fourth most frequent cancer in women across the globe. Though effective screening programmes are available, its role in effective prevention in a developing country like ours still remains an unanswered question and the probable reason behind this could be the difficulty in adopting liquid-based cytology (LBC) as the main screening program ahead of conventional pap smear (CPS). Aims and Objectives: This study was performed with an objective to analyse and interpret the samples by both CPS and LBC and to compare the both so as to find out the possibility of implementing LBC in a rural teaching institute of Tamilnadu like ours. Materials and methods: This was a prospective observational study which includes sample of 100 women who have attended the gynaecological outpatient department (OPD) of Vinayaka Missions Kirupananda, Variyar Medical College and Hospitals, Salem, Tamil Nadu. The slides were interpreted by two independent cytopathologists based on The Bethesda System and the results were analysed statistically. Results: The youngest patient was 19 years and the oldest was 68 years old. The most common age group in the study is 4 th decade. The commonest clinical presentation was discharge per vaginum (PV). Screening time was less with LBC which also showed cleaner background compared to CPS. Other parameters like organisms and epithelial cell abnormalities were detected in both CPS and LBC. Conclusion: Even though LBC was few steps above CPS while considering the smear background and time taken to screen the slides, CPS still remains the better among the two in our setup taking into consideration the cost efficacy it provides which is the main factor for the population in our rural setup.

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Section: Original Research Articlesupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Sankar

Selvi

Lenin

et al. 2019

Trop J Pathol Microbiol

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“…This was discordant with most of the other studies which observed white discharge per vaginum as the complaint in most of the patients12,14,15 that may be due to the fact that we selected symptomatic patients only and females with no symptoms or not seeming to be in a high risk zone were excluded from the study. Most of the cases (19 ie.…”

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confidence: 84%

Comparison between manual liquid based cytology and conventional Pap smear for evaluation of cervical lesions and it’s histopathological correlation in cases of epithelial abnormalities

Mittal¹

2018

jmscr

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Introduction: Pap smear has been most widely used screening method for cervical cytology since last 50 years. Despite of it reducing morbidity and mortality from cervical cancer by detecting precancerous lesions, false negativity rate of Pap smear is very high. Manual liquid based cytology has been developed as an alternative to conventional Pap smear to overcome its drawbacks. Main advantages of MLBC over CPS are increased percentage of representative cells, better presentation on slide, increased detection of abnormal or dysplastic cell and overall reduced number of unsatisfactory smears. Aim: to compare the number satisfactory smears and sensitivity in detecting intraepithelial abnormalities with both the techniques. Materials and Methods: this was a prospective study done on 200 symptomatic women. The sample of each patient was collected into a preservative vial by a cytobrush for MLBC and with an Ayre spatula directly on a slide for CPS. The results were interpreted according to the Bethesda system. The cases of intraepithelial lesions on cytology were followed and confirmed by histopathology. Results: MLBC showed slightly higher number of satisfactory smears ie. 175 (87.5 %) as compared to CPS (171 ie. 85.5%). The sensitivity of MLBC was much higher ie. 81.8% as compared to CPS which was 36.3%. The p-value was calculated as 0.15 which was not significant. Conclusion: MLBS was better than CPS in specimen adequacy and lesser obscurance of morphology of representative cells. The number of intraepithelial lesions detected on MLBC was higher but its superiority over CPS is still debatable.

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Conventional pap (papanicoloau) smear cytology in primary screening of cervical lesions & its comparison with manual liquid based cytology

Cited by 2 publications

References 0 publications

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Good old pap smear towers over the latest LBC for cervical screening: a study in a rural teaching institute of Tamil Nadu, India

Comparison between manual liquid based cytology and conventional Pap smear for evaluation of cervical lesions and it’s histopathological correlation in cases of epithelial abnormalities

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