Background: Gall bladder is very common organ to be affected by many pathological diseases which include wide spectrum of the lesions from congenital ones to inflammatory or premalignant and malignant lesions. Aim: Study the spectrum of histopathological lesions in gallbladder in Cholecystectomy specimens. Material and Methods: The study was conducted in the Department of Pathology, Muzaffarnagar Medical College, Muzaffarnagar. Total of 434 cholecystectomy specimen were studied. Result: Maximum cases (231/434 cases) were of chronic cholecystitis followed by acute cholecystitis (28 cases), eosinophilic cholecystitis (3 cases), cholesterolosis (31 cases), follicular cholecystitis (11 cases), xanthogranulomatous cholecystitis (9 cases) and one case each of mucocele and porcelain gall bladder. Metaplasia was seen in 83 cases (19.12%), dysplasia in 16 cases (3.68%) and malignancy in 5 cases (1.15%). Conclusion: Gall bladder with stones of prolonged duration associated with risk of premalignant and malignant conditions making histopathological examination necessary for timely recognization of lesion.

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Introduction: Gallbladder carcinoma (GBC) is the most common malignancy of biliary tract. It is associated with shortest median survival due to late diagnosis. Its clinical features are often mimicked by features of benign or inflammatory disease. Aim: The aim of the present study was to find out incidence of GBC in submitted cholecystectomy specimen and study its histological types at a tertiary teaching hospital in western Uttar Pradesh. Materials and Methods: It was a hospital based retro-prospective study on cholecystectomy specimens from June 2008-May 2018. Observations: Out of 2858 cases, 45 cases were malignant. M: F ratio was 1:3.5. Mean age was 51.38 years. Most cases were of adenocarcinoma-conventional type (75.57%). Conclusion: The present study came to the conclusion that GBC is more common in females. The age group is variable but it is in the middle age. Adenocarcinoma is the most common histologic subtype. Chronic cholelithiasis is a major risk factor. Timely surgery is the only available treatment.