Frequency and histological spectrum of gallbladder carcinoma- a tertiary teaching hospital based study on 2858 cholecystectomy specimens in western Uttar Pradesh, India

Abstract

Introduction: Gallbladder carcinoma (GBC) is the most common malignancy of biliary tract. It is associated with shortest median survival due to late diagnosis. Its clinical features are often mimicked by features of benign or inflammatory disease. Aim: The aim of the present study was to find out incidence of GBC in submitted cholecystectomy specimen and study its histological types at a tertiary teaching hospital in western Uttar Pradesh. Materials and Methods: It was a hospital based retro-prospective study on cholecystectomy specimens from June 2008-May 2018. Observations: Out of 2858 cases, 45 cases were malignant. M: F ratio was 1:3.5. Mean age was 51.38 years. Most cases were of adenocarcinoma-conventional type (75.57%). Conclusion: The present study came to the conclusion that GBC is more common in females. The age group is variable but it is in the middle age. Adenocarcinoma is the most common histologic subtype. Chronic cholelithiasis is a major risk factor. Timely surgery is the only available treatment.