Conventional papillary thyroid carcinoma: effects of cystic changes visible on ultrasonography on disease prognosis

Kim, Ja Young; Kim, Min Jung; Lee, Hye Sun; Kwak, Jin Young

doi:10.14366/usg.14028

Cited by 12 publications

(23 citation statements)

References 28 publications

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“…Prophylactic central lymph node dissection was routinely performed at the time of total thyroidectomy for all included patients. (26,27). However, the association between preoperative US features and recurrence of classic PTC was the primary concern of the present study, and none of these concepts were documented in the previous studies (26,27).…”

Section: Patientsmentioning

confidence: 65%

Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Kim¹,

Kwak²,

Kim³

et al. 2015

Radiology

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Section: Patientsmentioning

confidence: 65%

Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Kim¹,

Kwak²,

Kim³

et al. 2015

Radiology

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“…In the present study marked hypoechogenicity was rare among nodules in category 3a, indicating that this sign has an extremely low probability of appearing in thyroid nodules if other signs of malignancy are absent. Because cystic papillary thyroid cancer is extremely rare 19 and solid benign thyroid nodules are extremely common, a solid nodule cannot become a sign to assess benign and malignant nodules. Because color Doppler ultrasonography has no clear indicator for discriminating benign and malignant nodules 20 22 and because ultrasound elastography technology is immature 23,24 , these 2 modes were not used to examine the thyroid nodules included in the present study.…”

Section: Relationship Between Ti-rads Category and Ultrasonographic Fmentioning

confidence: 99%

Ultrasonography-Based Classification and Reporting System for the Malignant Risk of Thyroid Nodules

et al. 2017

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Objective: The aim of this study was to test the predictive value of a Thyroid Imaging Reporting and Data System (TI-RADS) for malignant thyroid nodules.Methods: Ultrasonographic data was examined for 910 thyroid nodules with histopathologically confirmed diagnoses. Nodules were placed into incomplete (category 0) or complete final categories (1, 2, 3a, 3b, 3c, 4, or 5) based on the presence and number of ultrasonographic features of malignancy, and the predictive value for the malignancy of nodules in categories 2 4 was assessed. Results:The overall rate of malignancy among thyroid nodules included in the study was 59.34%. The rate of malignancy gradually increased according to TI-RADS categories as follows: category 2, 5.4%; category 3 (a c), 36% to 92%; and category 4, 99.0%. When nodules of category 2 were counted as benign, the reliability of the TI-RADS classification for determining the risk of malignancy was as follows; sensitivity, 98.15%; specificity, 47.84%; positive predictive value, 73.31%; negative predictive value, 94.65%; and odds ratio, 48.61. Conclusions:The TI-RADS classification used in this study is relatively simple and provides a reliable measure of the risk of malignancy of thyroid nodules. (J Nippon Med Sch 2017; 84: 118 124)

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“…There have been plenty of studies concerning the US features of patients with PTC [15][16][17][18]. According to our knowledge, no reports have been published to date that evaluate the preoperative US features of patients with TT-UMP.…”

Section: Introductionmentioning

confidence: 99%

Comparing Clinicopathologic and Radiographic Findings Between TT-UMP, Classical, and Non-Encapsulated Follicular Variants of Papillary Thyroid Carcinomas

Başer¹,

Topaloğlu

Tam

et al. 2016

Endocr Pathol

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Thyroid tumors of uncertain malignant potential (TT-UMP) comprise an accepted subgroup of follicular-patterned thyroid tumors for which benignancy or malignancy cannot be precisely assessed. We aimed to evaluate the demographic characteristics, ultrasound (US) findings, and cytological results of patients with TT-UMP and compare these findings to a classical variant of papillary thyroid carcinoma (CV-PTC) and non-encapsulated follicular variant of PTC (NEFV-PTC) patients; we also evaluated the immunohistochemical characteristics of patients with TT-UMP. Twenty-four patients with TT-UMP, 672 with CV-PTC, and 132 with NEFV-PTC were included in the study. Mean longitudinal nodule size and median nodule volume were higher in the TT-UMP group than in the CV-PTC and NEFV-PTC groups (p < 0.001 and p < 0.001 for CV-PTC; p < 0.001 and p = 0.008 for NEFV-PTC). The presence of halo and peripheral vascularization was observed more frequently in the TT-UMP group than in the CV-PTC group (p = 0.002 and p = 0.024). Benign and follicular neoplasm/suspicious for follicular neoplasm cytological results were higher in the TT-UMP group than in the CV-PTC group (p = 0.030 and p = 0.001). US findings were similar between TT-UMP and NEFV-PTC groups (all, p > 0.05). However, none of the patients with TT-UMP were called malignant; 105 patients (31.2 %) of CV-PTC and 11 patients (9.5 %) of NEFV-PTC (infiltrative FV) were classified as malignant cytologically. Tumor size was higher in the TT-UMP group than in the CV-PTC and NEFV-PTC groups (p < 0.001 and p = 0.006). In the TT-UMP group, positive expression of HBME-1, CK-19, and Gal-3 was found in 50, 33.3, and 25 % of patients, respectively. This study demonstrated that none of the TT-UMP patients were evaluated as malignant in preoperative cytology. However, patients with TT-UMP had higher nodule and tumor sizes than CV-PTC and NEFV-PTC patients; US features were similar between NEFV-PTC and TT-UMP patients.

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Conventional papillary thyroid carcinoma: effects of cystic changes visible on ultrasonography on disease prognosis

Cited by 12 publications

References 28 publications

Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Association of Preoperative US Features and Recurrence in Patients with Classic Papillary Thyroid Carcinoma

Ultrasonography-Based Classification and Reporting System for the Malignant Risk of Thyroid Nodules

Comparing Clinicopathologic and Radiographic Findings Between TT-UMP, Classical, and Non-Encapsulated Follicular Variants of Papillary Thyroid Carcinomas

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