Conventional treatment versus vacuum therapy for diabetic foot ulcers treatment

Potula, Vigna Sai

doi:10.18203/2349-2902.isj20175482

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…At this stage, we applied NPWT to enhance wound healing by increasing local blood flow, reducing tissue edema, eliminating exudates, promoting cell hyperplasia, and preventing bacterial growth [7]. Similar to our report, some recent studies have also confirmed that NPWT is a safe and effective technique to accelerate wound healing [18,19]. AMG was another modern therapy that we combined with conventional treatment.…”

Section: Discussionsupporting

confidence: 79%

Using a combination therapy to combat scalp necrosis: a case report

2020

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Background: Chronic nonhealing wounds are very expensive to treat and debilitating, and they reduce healthrelated quality of life. Scalp necrosis is very rare due to its rich vascularity. However, any post-traumatic wounds with secondary infection can lead to scalp necrosis. Case presentation: We report a case of a 77-year-old Azerbaijani man with a history of diabetes who had a car accident and sustained a scalp wound. He underwent reconstructive surgery for the scalp wound. The wound became infected, and scalp necrosis developed following the surgery. There was no progress in wound healing in spite of conventional wound therapy. We combined maggot debridement therapy with negative-pressure wound therapy and amniotic membrane grafting for 7 months. Necrotic tissues began to be eliminated after the second use of larva therapy, and the wound became free of necrotic tissues with clear increase of granulated tissues after four treatments with maggot debridement therapy. Then, we applied negative-pressure wound therapy and amniotic membrane grafting to accelerate wound healing and improve wound closure. The patient's scalp wound recovered well, and he was discharged to home in good condition. Conclusions: Medical and wound care teams can benefit from this combination therapy when dealing with nonhealing necrotic wounds.

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Section: Discussionsupporting

confidence: 79%

Using a combination therapy to combat scalp necrosis: a case report

2020

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“…Conventional methods alone sometimes fail to heal chronic ulcers so that adjunctive methods may be necessary. 4 Hyperbaric oxygen therapy (HBOT) has been proposed to aid treatment of DFUs owing to its effects on the reversal of wound tissue hypoxia. 5 Administering 100% oxygen at 1 absolute atmospheric air (ATA) pressure for a period of time increases the amount of oxygen dissolved in the plasma 5-fold; from 0.3 to 1.5 ml/L 3 , and at 2.5 ATA, the dissolved oxygen content is approximately 5.5 ml/L 3 .…”

mentioning

confidence: 99%

“…Conventional methods alone sometimes fail to heal chronic ulcers so that adjunctive methods may be necessary. 4…”

mentioning

confidence: 99%

Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone

Salama

Eldeeb

El‐Barbary

et al. 2019

The International Journal of Lower Extremity Wounds

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Recent systematic reviews and meta-analyses have produced conflicting results about the efficacy of hyperbaric oxygen therapy (HBOT) in improving the healing rate for chronic diabetic foot wounds. This study aimed to assess the efficacy of systemic HBOT in healing of chronic nonischemic diabetic foot ulcer. Thirty adult patients having Wagner's grade 2 or 3 chronic diabetic foot ulcers, in whom the response to 30 days of standard wound care was not favorable, were prospectively randomized to have either HBOT (20-40 sessions) plus conventional treatment (n = 15) or conventional treatment alone (n = 15). Ischemic wounds and patients with contraindications to systemic HBOT were excluded. The primary end point was complete healing of the target ulcer. Secondary endpoints included the following: rate of ulcer healing at the end of treatment period and at 4 and 8 weeks thereafter as well as rate of amputation. A significantly greater percentage of HBOT-treated wounds (33.3%, 5/15) achieved complete closure than conventional therapy-treated wounds (0%, 0/15; P = .014) at the end of treatment. This significant difference was maintained throughout the 8 weeks of follow-up. Complications frequency was nonsignificantly different between both groups. Our study showed that HBOT plus conventional therapy appears as safe as and probably more effective than conventional therapy alone for the healing of chronic nonischemic diabetic foot wounds. Larger studies are required to confirm its specific indications.

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“…These factors result in longer time taken to heal and reduce the tensile strength of the wound. 3 In diabetes mellitus, there are numerous derangements such as ischemia, neuropathy, microangiopathy, impaired immunity and defective angiogenesis. 4 During hyperglycemia, free radicals also increase which often leads to damage to blood vessels, accelerated atherosclerosis, diabetic nephropathy, neuropathy and retinopathy.…”

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confidence: 99%

“…They further get infected leading to cellulitis, necrosis and formation of diabetic wound. 3 Old age, poor glycemic control, diabetic neuropathy, previous history of amputation or ulcers are all risk factors for diabetic ulcers. 3 Ulcers can be prevented by good glycemic control, detailed examination and proper foot care.…”

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confidence: 99%

Comparative study on microbiological and histopathological examination of diabetic wounds managed by conventional dressing and vacuum assisted closure therapy

Kumar¹,

Raja²,

Haritha³

et al. 2021

Int Surg J

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Background: Diabetes mellitus and its complications are rising. Managing the diabetic foot wound is very challenging. Early intervention and intense management using modern technique will improve the diabetic wounds for a definitive procedure and also prevent, reduce the level of amputation of extremity. Our study compares the microbiological and histopathological results of diabetic wounds managed by conventional dressing and VAC (vacuum assisted closure) therapy.Methods: This was an institutional based prospective study conducted between July 2018 and July 2019 consisting of 50 patients with diabetic wound of lower extremities. Patients were divided into group A- 25 patients underwent conventional dressing and group B- 25 patients underwent negative pressure wound therapy (NPWT). Wound swab and tissue biopsy was obtained on day 0 and day 10 from both groups and compared.Results: Among patients, 76% and 24% were males and females respectively. Histopathologically, necrosis and inflammatory cell infiltrate were significantly decreased in group B compared to group A. Angiogenesis increased notably in group B. On microbiological grounds, from both groups Pseudomonas aeruginosa was found to be the most common organism on day 0 and 10. But the prevalence of infection in group B was grossly reduced when compared to group A.Conclusions: VAC therapy is a better modality to treat diabetic wound compared to conventional dressing as it accelerates the healing of a chronic wound by increasing angiogenesis and decreasing necrosis, inflammatory cell infiltrate and microbial growth.

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Conventional treatment versus vacuum therapy for diabetic foot ulcers treatment

Cited by 6 publications

References 5 publications

Using a combination therapy to combat scalp necrosis: a case report

Using a combination therapy to combat scalp necrosis: a case report

Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone

Comparative study on microbiological and histopathological examination of diabetic wounds managed by conventional dressing and vacuum assisted closure therapy

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