Convergent Aedes and Drosophila CidB interactomes suggest cytoplasmic incompatibility targets are conserved

Oladipupo, Seun Olaitan; Carroll, Jazmine D.; Beckmann, John F.

doi:10.1016/j.ibmb.2023.103931

Cited by 3 publications

(1 citation statement)

References 58 publications

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“…Like other CE‐clan DUBs, CidB demonstrates a preference for K63‐linked polyUb. Interestingly, CidA does not affect CidB DUB activity, but more likely alters its localization and access to substrates (Beckmann et al , 2017; Oladipupo et al , 2023; Terretaz et al , 2023).…”

Section: Ub‐like Hydrolysis By Ce‐clan Proteasesmentioning

confidence: 99%

Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system

2023

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Regulation through post‐translational ubiquitin signaling underlies a large portion of eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have evolved mechanisms to manipulate or subvert the host ubiquitin system. Bacteria are particularly adept at this and rely heavily upon ubiquitin‐targeted virulence factors for invasion and replication. Despite lacking a conventional ubiquitin system of their own, many bacterial ubiquitin regulators loosely follow the structural and mechanistic rules established by eukaryotic ubiquitin machinery. Others completely break these rules and have evolved novel structural folds, exhibit distinct mechanisms of regulation, or catalyze foreign ubiquitin modifications. Studying these interactions can not only reveal important aspects of bacterial pathogenesis but also shed light on unexplored areas of ubiquitin signaling and regulation. In this review, we discuss the methods by which bacteria manipulate host ubiquitin and highlight aspects that follow or break the rules of ubiquitination.

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Section: Ub‐like Hydrolysis By Ce‐clan Proteasesmentioning

confidence: 99%

Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system

2023

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Using Baker’s Yeast to Determine Functions of Novel Wolbachia (and Other Prokaryotic) Effectors

Murphy,

Beckmann

2023

Methods in Molecular Biology

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The prevalence of Wolbachia in multiple cockroach species and its implication for urban insect management

Oladipupo

Laidoudi

Beckmann

et al. 2023

Journal of Economic Entomology

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Cockroach management relies heavily on the use of conventional insecticides in urban settings, which no longer provide the anticipated level of control. Knowledge of cockroach endosymbionts, like Wolbachia, might provide novel avenues for control. Therefore, we screened 16 cockroach species belonging to 3 families (Ectobiidae, Blattidae, and Blaberidae) for the presence of Wolbachia. We mapped the evolution of Wolbachia-cockroach relationships based on maximum likelihood phylogeny and phylogenetic species clustering on a multi-loci sequence dataset (i.e., coxA, virD4, hcpA, and gatB) of Wolbachia genes. We confirmed the previous report of Wolbachia in 1 Ectobiid species; Supella longipalpa (Fab.), and detected the presence of Wolbachia in 2 Ectobiid species; Balta notulata (Stål) and Pseudomops septentrionalis Hebard, and 1 Blaberid species; Gromphadorhina portentosa (Schaum). All cockroach-associated Wolbachia herein detected were clustered with the ancestor of F clade Wolbachia of Cimex lectularius L. (bed bugs). Since Wolbachia provision C. lectularius with biotin vitamins that confer reproductive fitness, we screened the cockroach-associated Wolbachia for the presence of biotin genes. In toto, our results reveal 2 important findings: (i) Wolbachia is relatively uncommon among cockroach species infecting about 25% of species investigated, and (ii) cockroach-associated Wolbachia have biotin genes that likely provide nutritional benefits to their hosts. Thus, we discuss the potential of exploring Wolbachia as a tool for urban insect management.

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Convergent Aedes and Drosophila CidB interactomes suggest cytoplasmic incompatibility targets are conserved

Cited by 3 publications

References 58 publications

Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system

Ubiquitin‐targeted bacterial effectors: rule breakers of the ubiquitin system

Using Baker’s Yeast to Determine Functions of Novel Wolbachia (and Other Prokaryotic) Effectors

The prevalence of Wolbachia in multiple cockroach species and its implication for urban insect management

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