Convergent Paired Electrolysis for the Synthesis of Pyrazolyl‐Substituted Tetrahydroisoquinolines

Abstract

A convergent paired electrolysis method for the synthesis of 1‐pyrazolyl‐substituted tetrahydroisoquinolines has been developed. The reaction proceeded without any transition metal catalyst and chemical oxidant. The desired products could be isolated with high yields (80‐99%) in 60‐80 min. 108% Faradaic efficiency and the gram‐scale synthesis (84%) were observed. Mechanism studies revealed that the C‐N bond formation process might mainly involve in nucleophilic addition reaction.