2015
DOI: 10.1038/nri.2015.7
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Converging roles of caspases in inflammasome activation, cell death and innate immunity

Abstract: Inflammatory and apoptotic caspases are central players in inflammation and apoptosis, respectively. However, recent studies have revealed that these caspases have functions beyond their established roles. In addition to mediating cleavage of the inflammasome-associated cytokines interleukin-1β (IL-1β) and IL-18, inflammatory caspases modulate distinct forms of programmed cell death and coordinate cell-autonomous immunity and other fundamental cellular processes. Certain apoptotic caspases assemble structurall… Show more

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Cited by 569 publications
(482 citation statements)
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References 197 publications
(340 reference statements)
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“…13 In other immune cells other proteases may activate IL-1b, e.g., proteinase-3 in neutrophils, granzyme A in NK cells, chymase in mast cells, and metalloendopeptidase meprin A in epithelial cells. 5,14 Inflammasomes are cytosolic wheel-like complexes composed by the assembly of NACHT, LRR and PYD domains-containing proteins (NLRP), the linker molecule apoptosis-associated specklike protein (ASC), and caspase-1 ( Figure 2).…”
Section: Il-1bmentioning
confidence: 99%
“…13 In other immune cells other proteases may activate IL-1b, e.g., proteinase-3 in neutrophils, granzyme A in NK cells, chymase in mast cells, and metalloendopeptidase meprin A in epithelial cells. 5,14 Inflammasomes are cytosolic wheel-like complexes composed by the assembly of NACHT, LRR and PYD domains-containing proteins (NLRP), the linker molecule apoptosis-associated specklike protein (ASC), and caspase-1 ( Figure 2).…”
Section: Il-1bmentioning
confidence: 99%
“…From an evolutionary perspective, pyroptosis of cells harboring intracellular bacteria or in which LPS has breached the plasma membrane is an effective means of eliminating an intracellular bacterial niche and activating the host through release of inflammatory mediators such as IL-1β, while sparing uninfected neighboring cells (13,(28)(29)(30). Thus, pyroptosis induced by inflammatory caspases 1/4/5/11 is an innate immune response distinct from the canonical inflammasome activation pathway via cell-surface TLR4 (11,(31)(32)(33)(34). However, caspase-11 can also be immunopathologic in sepsis (35).…”
Section: Introductionmentioning
confidence: 99%
“…Pyroptosis is uniquely dependent on inflammatory caspases such as caspase-1, murine caspase-11, and its human homologs caspases-4 and -5. Caspase-1 is a central component of canonical NLRP3, NLRC4, AIM2, and pyrin inflammasomes, and its activation leads to proteolytic processing and secretion of proinflammatory cytokines IL-1 and IL-18 as well as to pyroptosis (Man and Kanneganti, 2016). Intracellular lipopolysaccharide (LPS) from gram-negative bacteria can directly bind caspases-4, -5, or -11, and the activation of these caspases causes pyroptosis and non-canonical inflammasome activation (Hagar et al, 2013;Kayagaki et al, 2013;Shi et al, 2014).…”
mentioning
confidence: 99%