Conversion of d-psicose to allitol by Enterobacter agglomerans strain 221e

Muniruzzaman, Syed; Tokunaga, Hisahiro; Izumori, Ken

doi:10.1016/0922-338x(95)93989-w

Cited by 34 publications

(17 citation statements)

References 13 publications

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“…Previous studies confirmed the validity of this approach; for example, L-xylulose, D-tagatose, D-sorbose, Dpsicose, D-talitol, and allitol were successfully produced using microorganisms [7][8][9][10][11]. Among these, allitol is a rare hexitol that is synthesised by the reduction of D-psicose [12]. In the natural world, allitol is present in plants of the Itea genus (Itea virginica L.) and certain fungi [13,14].…”

Section: Introductionmentioning

confidence: 61%

“…The use of both bacterial reduction (using Enterobacter strain 221) and enzymatic reaction (using ribitol dehydrogenase: RDH) to produce allitol from Dpsicose has been reported [12,15,16]. In recent studies, a new RDH from Providencia alcalifaciens RIMD 1656011 and formate dehydrogenase (FDH) from the methanolassimilating yeast Ogataea parapolymorpha DL-1 were cloned and characterised [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of allitol from D-psicose using ribitol dehydrogenase and formate dehydrogenase

Hassanin¹,

Letsididi²,

Koko³

et al. 2017

Trop. J. Pharm Res

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Section: Introductionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Synthesis of allitol from D-psicose using ribitol dehydrogenase and formate dehydrogenase

Hassanin¹,

Letsididi²,

Koko³

et al. 2017

Trop. J. Pharm Res

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“…The crystal structure was analyzed by 13 C NMR spectroscopy. The main signals in the 13 C NMR spectra of the isolated product were identical with those of authentic D-allose. The retention time of HPLC was indistinguishable from that of authentic D-allose.…”

Section: Resultsmentioning

confidence: 99%

“…The product was identified by HPLC analysis, 13 C NMR spectrophotometer (model ALPHA 400, JEOL, Tokyo) at 400 MHz according to the method of Gray, optical rotation with P-1030 (Jasco, Tokyo), and melting point measurements.…”

Section: Chemicalsmentioning

confidence: 99%

Production of l-allose and d-talose from l-psicose and d-tagatose by l-ribose isomerase

Terami

Uechi

Nomura

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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l-ribose isomerase (L-RI) from Cellulomonas parahominis MB426 can convert l-psicose and d-tagatose to l-allose and d-talose, respectively. Partially purified recombinant L-RI from Escherichia coli JM109 was immobilized on DIAION HPA25L resin and then utilized to produce l-allose and d-talose. Conversion reaction was performed with the reaction mixture containing 10% l-psicose or d-tagatose and immobilized L-RI at 40 °C. At equilibrium state, the yield of l-allose and d-talose was 35.0% and 13.0%, respectively. Immobilized enzyme could convert l-psicose to l-allose without remarkable decrease in the enzyme activity over 7 times use and d-tagatose to d-talose over 37 times use. After separation and concentration, the mixture solution of l-allose and d-talose was concentrated up to 70% and crystallized by keeping at 4 °C. l-Allose and d-talose crystals were collected from the syrup by filtration. The final yield was 23.0% l-allose and 7.30% d-talose that were obtained from l-psicose and d-tagatose, respectively.

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“…The processes for producing allitol and D-talitol have been previously reported and involve isolation and identiˆcation from Iteailcifolia and Himanthalia elongate. 1) In addition, the fermentation and production of allitol and D-talitol from D-psicose, a ketohexose, by Enterobacter agglomerans 2) and Candida famata 3) and L-iditol from L-sorbose, a ketohexose, by Candida intermedia 4) have been reported. However, even with these processes, it is very di‹cult to produce large amounts of these sugar alcohols.…”

Section: Introductionmentioning

confidence: 99%

Possibility as Monosaccharide Laxative of Rare Sugar Alcohols

Oosaka

2009

YAKUGAKU ZASSHI

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Allitol, D-talitol and L-iditol are sugar alcohols that are rare in nature. Due to their previous rarity, little is known about the laxative eŠects of these rare sugar alcohols. Therefore, reliable data on the laxative eŠect that these sugar alcohols cause in experimental animals could help to evaluate the eŠectiveness of new monosaccharide laxative drugs. To investigate the laxative eŠect of rare sugar alcohols, the study was designed to observe the diarrhea that occurred after oral administration of these sugar alcohols in mice. Moreover, to investigate the in‰uence on intestinal function of rare sugar alcohols, the study was designed to examine small intestine transit and the luminal water content. Results indicated that rare sugar alcohols have a laxative eŠect in mice. Diarrhea started at a dose of 4.95 g/kg of rare sugar alcohols. There was a statistically signiˆcant laxative eŠect for D-talitol and L-iditol at a dose of 9.9 g/kg as compared to vehicle. Moreover, rare sugar alcohols signiˆcantly increased the small intestinal transit and the luminal water content of the small intestine and cecum in mice as compared to each vehicle. Overall, L-iditol greatly changes the function of intestine. In conclusion, rare sugar alcohols increase water content in small intestine and accelerate small intestine transit. These results support laxative eŠect of rare sugar alcohols. Therefore, rare sugar alcohols may be useful as monosaccharide laxatives and may be used to treat constipation.

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Conversion of d-psicose to allitol by Enterobacter agglomerans strain 221e

Cited by 34 publications

References 13 publications

Synthesis of allitol from D-psicose using ribitol dehydrogenase and formate dehydrogenase

Synthesis of allitol from D-psicose using ribitol dehydrogenase and formate dehydrogenase

Production of l-allose and d-talose from l-psicose and d-tagatose by l-ribose isomerase

Possibility as Monosaccharide Laxative of Rare Sugar Alcohols

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