Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro

Miller, Lynne; Rance, Michael J.; Shaw, John S.; Traynor, John R.

doi:10.1016/0014-2999(85)90197-9

Cited by 14 publications

(6 citation statements)

References 15 publications

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“…This is similar to findings in CNS tissue (Griffiths et al, 1983;Gillan et al, 1985;Dixon & Traynor, 1987;1990) and mouse vas deferens (Miller et al, 1985). Since the process in myenteric plexus-longitudinal muscle occurs in well-washed tissue slices it is unlikely to be due to non-specific hydrolases such as might be released by damaged cells.…”

Section: Discussionsupporting

confidence: 88%

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Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin

Dixon

Traynor

1990

British J Pharmacology

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Section: Discussionsupporting

confidence: 88%

“…[Leu5]enkephalin may be produced (Miller et al, 1985;Dixon & Traynor, 1987) and this pentapeptide may contribute to the observed pharmacological actions of the dynorphin fragments (Miller et al, 1985). Indeed the peptidase inhibitors may stabilize [Leu5]enkephalin and therefore favour formation of this pentapeptide (Dixon & Traynor, 1987).…”

Section: Introductionmentioning

confidence: 99%

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin

Dixon

Traynor

1990

British J Pharmacology

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“…A Met-ENK sequence is present in POMC, and three Leu-ENK sequences are included in PDYN. There is no clear evidence that POMC would serve as a precursor for met-ENK, whereas Leu-ENK has been reported to be generated from PDYN in some tissues (Miller et al, 1985;Zamir et al, 1984).…”

Section: Literature Review and Resultsmentioning

confidence: 99%

Immunocytochemical localization of neuropeptides in the adrenal medulla

Pelto‐Huikko

1989

J. Elec. Microsc. Tech.

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The distribution of neuropeptides exhibits pronounced interspecies heterogeneity. Neuropeptides may function as hormones secreted from chromaffin cells or as neurotransmitters/neuromodulators released from nerve terminals. However, other possible functions such as trophic or intracellular effects should also be considered. Thus, to understand the role of neuropeptides, it is important to explore their localization in different species. The distribution of enkephalins, neurotensin, neuropeptide Y, calcitonin gene-related peptide, and galanin in the adrenal medulla of rat, cat, hamster, and mouse is presented in detail.

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“…A more plausible explanation therefore is that the Leu-enkephalin quantified after kindling stimulation is derived from prodynorphin localized in mossy fibers (McGinty et al, 1983), given the simultaneous detection of dynorphin-A products. The prodynorphin precursor contains multiple copies of the Leuenkephalin sequence and production of Leu-enkephalin by dynorphinergic neurons has been demonstrated (Zamir et al, 1984;Miller et al, 1985).…”

Section: Fig 6 Amentioning

confidence: 99%

Amygdala Kindling Modifies Extracellular Opioid Peptide Content in Rat Hippocampus Measured by Microdialysis

Rocha

Evans²,

Maidment³

1997

Journal of Neurochemistry

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Opioid peptide release in the hippocampus was shown to be increased immediately following amygdala kindling stimulation in freely moving rats using microdialysis combined with a universal opioid peptide radioimmunoassay (RIA). Extracellular opioid peptide levels were elevated (55% above basal levels) within the first 10 min after electrical stimulation‐induced partial seizures in previously nonkindled animals. Fully kindled rats showed lower extracellular opioid peptide levels (40% reduction) during the interictal period [16 ± 2.1 days (mean ± SEM) after the last stage V seizure], in comparison with values obtained from the sham‐kindled group under basal conditions. However, opioid peptide release in fully kindled rats increased above 152% of interictal levels within the first 20 min after onset of fully kindled seizures, attaining peak levels equal to that of the partial kindled group and returning to prestimulation conditions 40–60 min following the ictal events. The majority of the immunoreactive material recovered from the hippocampus within the first 20 min following partial and generalized kindled seizures coeluted with dynorphin‐A (1–6), dynorphin‐A (1–8), and Leu‐enkephalin by HPLC/RIA analysis. It is proposed that the enhanced opioid peptide release in hippocampus induced by amygdala kindling stimulation might be associated with either enhanced excitability or seizure suppression as seizure susceptibility fluctuates. The reduced interictal opioid peptide levels may also underlie some interictal behavioral disturbances.

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Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro

Cited by 14 publications

References 15 publications

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin

Immunocytochemical localization of neuropeptides in the adrenal medulla

Amygdala Kindling Modifies Extracellular Opioid Peptide Content in Rat Hippocampus Measured by Microdialysis

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Conversion of dynorphin-(1-9) to [Leu5]enkephalin by the mouse vas deferens in vitro

Cited by 14 publications

References 15 publications

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu5]enkephalin

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu5]enkephalin

Immunocytochemical localization of neuropeptides in the adrenal medulla

Amygdala Kindling Modifies Extracellular Opioid Peptide Content in Rat Hippocampus Measured by Microdialysis

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Product

Resources

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Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin

Evidence that the agonist action of dynorphin A(1–8) in the guinea‐pig myenteric‐plexus may be mediated partly through conversion to [Leu⁵]enkephalin