Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B′ methyltransferase family in Coffea arabica

Mizuno, Kouichi; Matsuzaki, Masahiro; Kanazawa, Shiho; Tokiwano, Tetsuo; Yoshizawa, Yuko; Kato, Masaaki

doi:10.1016/j.bbrc.2014.09.043

Cited by 33 publications

(27 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2007; Ashihara et al, 2010); more complex glycosides also occur (Gregory, 1998). Enzymes that would allow the N-glucoside and trigonelline to act as mobilizable storage forms have been characterized (Upmeier et al, 1988;Shimizu and Mazzafera, 2000;Mizuno et al, 2014). Brassicaceae contain the b-D-glucosyl ester of nicotinic acid, which almost certainly acts as a mobilizable storage form (Li et al, 2015).…”

Section: Pyridoxine (B 6 )mentioning

confidence: 99%

Does Abiotic Stress Cause Functional B Vitamin Deficiency in Plants?

et al. 2016

View full text Add to dashboard Cite

B vitamins are the precursors of essential metabolic cofactors but are prone to destruction under stress conditions. It is therefore a priori reasonable that stressed plants suffer B vitamin deficiencies and that certain stress symptoms are metabolic knock-on effects of these deficiencies. Given the logic of these arguments, and the existence of data to support them, it is a shock to realize that the roles of B vitamins in plant abiotic stress have had minimal attention in the literature (100-fold less than hormones) and continue to be overlooked. In this article, we therefore aim to explain the connections among B vitamins, enzyme cofactors, and stress conditions in plants. We first outline the chemistry and biochemistry of B vitamins and explore the concept of vitamin deficiency with the help of information from mammals. We then summarize classical and recent evidence for stress-induced vitamin deficiencies and for plant responses that counter these deficiencies. Lastly, we consider potential implications for agriculture.

show abstract

Section: Pyridoxine (B 6 )mentioning

confidence: 99%

Does Abiotic Stress Cause Functional B Vitamin Deficiency in Plants?

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The finding supports the study by Mizuno et al (2014) who used the N-methyltransferase assay with S-adenosyl[methyl-14C]methionine to confirm these enzymes catalyzing the conversion of nicotinate to trigonelline and the expression profiles for two genes homologous to caffeine synthases were similar to the accumulation profile of trigonelline.…”

Section: Genotypes Snpssupporting

confidence: 89%

“…These are candidate genes which may control the variability of coffee quality . Genes regulating the main chemical components that are thought to be involved in the flavour and sensory quality of coffee are listed in Table 2.8 (Campa et al, 2003;Denoeud et al, 2014;Geromel et al, 2006;Joët et al, 2009;Kato and Mizuno, 2004;Koshiro et al, 2006;Lepelley et al, 2012;Leroy et al, 2011;Leroy et al, 2005;Mahesh et al, 2006;Mizuno et al, 2014;Mizuno et al, 2003b;Ogawa et al, 2001;Ogita et al, 2004;Perrois et al, 2014;Privat et al, 2011;Privat et al, 2008;Simkin et al, 2006;Uefuji et al, 2003).…”

Section: Gene Identificationmentioning

confidence: 99%

“…ATP-ADP; Red squares: SAM-SAH). Mizuno et al (2014) found that production of trigonelline from nicotinate is catalyzed by a Nmethyltransferase, as is caffeine synthase. In addition, the expression profiles for two genes homologous to caffeine synthases were similar to the accumulation profile of trigonelline.…”

Section: Snp Detection and Kegg Pathway-based Analysis For Trigonellimentioning

confidence: 99%

“…In particular, a nucleotide mutation in the CADXMT1 gene (Maluf et al, 2009) coding for an N-methyltransferase (NMT) enzyme which caused a natural caffeine-free mutation (called "caffeine-free") in an C. arabica plant (Silvarolla et al, 2004) has been reported. For trigonelline, enzymes catalysed the conversion of nicotinate to trigonelline, coffee trigonelline synthases (termed CTgS1 and CTgS2), have been isolated and characterized (Mizuno et al, 2014). However, these caffeine/trigonelline biosynthesis genes were identified based on sequences derived from a limited number of specific arabica cultivars (e.g., Caturra and Laurina).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genomic studies of biochemical compounds determining arabica coffee (Coffea arabica L.) quality

Tran¹

View full text Add to dashboard Cite

Coffee is an important crop globally. Improving coffee quality is a primary breeding target that would benefit from understanding of trait inheritance and ancestral genetic information. However, comparatively little information exists on the genetics of quality and the relationships between wild and cultivated coffee genotypes, especially arabica coffee (Coffea arabica L.) which accounts for almost 60% of coffee production globally. The complex polyploidy genome and limited genomic information for C. arabica have impeded the progress of genetic studies. Arabica coffee is among the major organisms that do not have a reference genome. This project aimed to develop and utilise genomic resources in genetic studies of arabica coffee quality. The relationship between coffee species and the position of arabica within the Coffeeae tribe were investigated using complete chloroplast genome sequences to determine the value of these genetic resources in breeding. A draft genome sequence of arabica coffee was developed. Marker-trait associations were studied for caffeine and trigonelline, the two principal compounds known to be related to coffee quality, paving the way for developing new improved varieties with preferred levels of these compounds in the coffee beans.Chloroplast genomes of 16 coffee species were sequenced and their phylogeny constructed. Results support distinct Psilanthus and Coffea clades. It is likely that C. canephora is a hybrid that has a Psilanthus maternal genome but received much of its nuclear genome from Coffea. The maternal genomes of C. arabica and C. canephora are divergent. This result is in agreement with the fact that the chloroplast genome of arabica should be that of the maternal parent i.e. C. eugenioides. There were two species (C. humblotiana and C. tetragona) close to C. arabica and one species (P. ebracteolatus) close to C. canephora containing almost no caffeine. They could serve as important materials in arabica quality breeding and research.For the association study, 232 diverse arabica coffee accessions originating from 27 countries were harvested from the germplasm collection at CATIE (Tropical Agricultural Research and Higher Education Centre), Costa Rica. Substantial variation between genotypes was observed for bean morphology attributes. Non-volatiles including caffeine and trigonelline showed larger variation in range than was previously reported. Results of targeted analysis of 18 volatiles from 35 accessions also showed significant variation. No strong correlation was found between bean morphology and the levels of non-volatile or volatile compounds, implying that it is difficult to select for low or high non-volatile and volatile compounds based on bean physical characteristics. However, it also indicates that breeding for desirable combinations of traits (i.e. large bean size, low caffeine, high trigonelline, and favourable volatiles) is possible.ii The genome of the most popular arabica variety (K7) in Australia was sequenced. Genome assembly was performed using b...

show abstract

Biosynthesis of Purine Alkaloids

2020

Plant Nucleotide Metabolism ‐ Biosynthesis, Degradation, and Alkaloid Formation

View full text Add to dashboard Cite

Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B′ methyltransferase family in Coffea arabica

Cited by 33 publications

References 25 publications

Does Abiotic Stress Cause Functional B Vitamin Deficiency in Plants?

Does Abiotic Stress Cause Functional B Vitamin Deficiency in Plants?

Genomic studies of biochemical compounds determining arabica coffee (Coffea arabica L.) quality

Biosynthesis of Purine Alkaloids

Contact Info

Product

Resources

About