Cooling devices in laser therapy

Das, Anupam; Sarda, Aarti; De, Abhishek

doi:10.4103/0974-2077.197028

Cited by 33 publications

(32 citation statements)

References 24 publications

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“…For instance, delivering light using an optical fiber or an endoscopic device may reduce the optical pathlength in tissue and lower the possibility of tissue damage. Another possible approach that can be explored in the future is to cool the tissue before heating so that the thermal damage to the tissue can be mitigated 34 . Finally, although the microrocket can move through trunk blood vessels, it is too large to pass through arterioles and capillaries.…”

Section: Discussionmentioning

confidence: 99%

Micro-rocket robot with all-optic actuating and tracking in blood

et al. 2020

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Micro/nanorobots have long been expected to reach all parts of the human body through blood vessels for medical treatment or surgery. However, in the current stage, it is still challenging to drive a microrobot in viscous media at high speed and difficult to observe the shape and position of a single microrobot once it enters the bloodstream. Here, we propose a new micro-rocket robot and an all-optic driving and imaging system that can actuate and track it in blood with microscale resolution. To achieve a high driving force, we engineer the microrobot to have a rocket-like tripletube structure. Owing to the interface design, the 3D-printed micro-rocket can reach a moving speed of 2.8 mm/s (62 body lengths per second) under near-infrared light actuation in a blood-mimicking viscous glycerol solution. We also show that the micro-rocket robot is successfully tracked at a 3.2-µm resolution with an optical-resolution photoacoustic microscope in blood. This work paves the way for microrobot design, actuation, and tracking in the blood environment, which may broaden the scope of microrobotic applications in the biomedical field.

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Section: Discussionmentioning

confidence: 99%

Micro-rocket robot with all-optic actuating and tracking in blood

et al. 2020

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“…In the field of dermatology, cooling that is not for therapeutic purposes is commonly employed to protect the epidermis and skin during treatment 5 . Cooling is used for therapeutic purposes in actinic keratosis, warts, superficial tumors, and even malignant lesions by nonselective tissue destruction, in terms of “cryosurgery” or “the cryosurgical technique.” 6,7 Single or multiple freeze/thaw cycle(s) induce irreversible damage to cells when the tissue temperature reaches far below the freezing point of the tissue water 8 .…”

Section: Discussionmentioning

confidence: 99%

Split‐face comparative trial of 785‐nm picosecond neodymium:yttrium‐aluminum‐garnet laser and precision cryotherapy combination treatment for facial benign pigmented lesions

Park

Han

Koh

et al. 2021

Dermatologic Therapy

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Cryotherapy (or cryosurgery) has been performed to treat various skin lesions in the field of dermatology; however, to the best of our knowledge, no study has investigated its efficacy and safety for benign pigmented lesions. Therefore, we conducted a split‐face study to evaluate the efficacy and safety of cryotherapy in the treatment of benign pigmented lesions. A total of five subjects were included. Picosecond laser therapy was performed to treat the whole face and cryotherapy for half the face. Four weeks after completing the treatment sessions, patients showed more clinical improvement on the laser and cryotherapy combination treatment side than on the laser‐only side, with no adverse events. Our study demonstrated that cryotherapy is a potential adjuvant therapeutic modality for benign pigmented lesions.

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“…Hence, compared with potential adverse events seen with isotretinoin, the treatment is safe to use . The minor epidermal erosions observed during laser treatment might be due to increased heat deposition to the skin, either due to insufficient cooling, bulk heating, or inadequate removal of residual gold microparticles from the skin surface which can potentially be avoided by increased awareness to treatment procedures. Dark macules were observed in three patients, which is believed to stem from a ruptured pustule.…”

Section: Discussionmentioning

confidence: 99%

Acne Treatment With Light Absorbing Gold Microparticles and Optical Pulses: An Open‐Label European Multi‐Centered Study in Moderate to Moderately Severe Acne Vulgaris Patients

et al. 2019

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Background and Objective: Recently, a novel acne treatment based on selective photothermolysis of pilosebaceous units with follicular delivery of inert gold microparticles as an exogenous chromophore and diode laser pulses has been developed. To evaluate the efficacy and safety of a single monotherapy treatment regimen with gold microparticles and diode laser exposure in patients with moderate and moderately severe acne. Further, to evaluate the added benefit of a second treatment regimen combined with pharmaceutical acne treatment in patients with inadequate initial response. Materials and Methods: Patients with moderate and moderately severe facial acne were recruited in this openlabel, pilot study. A single treatment regimen consisted of three weekly facial treatments with topically applied gold microparticles and diode laser pulses. Outcome measures were the proportion of patients with ≥40% improvement in number of acne lesions (weighted lesion count [WLC]) at 12 weeks (single treatment regimen, primary outcome measure), 24, and 36 weeks from baseline (two treatment regimens), safety, and patient satisfaction. Results: A total of 28 patients were enrolled in the study (18 males, 10 females, 19 patients with moderate acne severity, 9 with moderately severe, mean age: 19.8 years). Twenty-five patients underwent analysis for outcome measures. After a single monotherapy treatment regimen, 76% patients (19/25) achieved ≥40% reduction in WLC (mean WLC reduction: 63%; SD: 13%). Of the patients undergoing two treatment regimens (n = 9 patients), 56% experienced a reduction in acne lesion burden (WLC) ≥40% at 24 weeks and 89% 36 weeks post-baseline. Mean pain score was 4.0 (SD: 1.3), and transient erythema and perifollicular edema were commonly noted after treatment. Most patients (81%) were either "satisfied" or "very satisfied" with the treatment. Conclusion: Acne therapy based on selective photothermolysis with gold microparticles shows promise and may be used in treatment of moderate to moderately severe acne.

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Cooling devices in laser therapy

Cited by 33 publications

References 24 publications

Micro-rocket robot with all-optic actuating and tracking in blood

Micro-rocket robot with all-optic actuating and tracking in blood

Split‐face comparative trial of 785‐nm picosecond neodymium:yttrium‐aluminum‐garnet laser and precision cryotherapy combination treatment for facial benign pigmented lesions

Acne Treatment With Light Absorbing Gold Microparticles and Optical Pulses: An Open‐Label European Multi‐Centered Study in Moderate to Moderately Severe Acne Vulgaris Patients

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