CoOOH nanosheets-coated g-C3N4/CuInS2 nanohybrids for photoelectrochemical biosensor of carcinoembryonic antigen coupling hybridization chain reaction with etching reaction

Zhang, Kangyao; Lv, Shuzhen; Zhou, Qian; Tang, Dianping

doi:10.1016/j.snb.2019.127631

Cited by 214 publications

(75 citation statements)

References 48 publications

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“…They are also important in the choice of treatment approach, assessing the treatment efficacy, mitigating treatment toxicity, and detecting any recurrence of the disease [ 46 ]. Although various types of biomarkers have been found in tumors and in cancer cells, most of the well-known cancer biomarkers that have been detected by biosensors have been protein-based [ 47 , 48 ]. Several conventional assay-based techniques, including polymerase chain reaction (PCR), flow cytometry, and immunohistochemistry have been exploited for the quantification of various biomarkers [ [49] , [50] , [51] , [52] , [53] ].…”

Section: Scaffold-based Materials In Biosensing For Infectious Disease and Cancer Diagnosismentioning

confidence: 99%

Applications of scaffold-based advanced materials in biomedical sensing

Sarkhosh-Inanlou

Shafiei‐Irannejad

Azizi

et al. 2021

TrAC Trends in Analytical Chemistry

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There have been many efforts to synthesize advanced materials that are capable of real-time specific recognition of a molecular target, and allow the quantification of a variety of biomolecules. Scaffold materials have a porous structure, with a high surface area and their intrinsic nanocavities can accommodate cells and macromolecules. The three-dimensional structure (3D) of scaffolds serves not only as a fibrous structure for cell adhesion and growth in tissue engineering, but can also provide the controlled release of drugs and other molecules for biomedical applications. There has been a limited number of reports on the use of scaffold materials in biomedical sensing applications. This review highlights the potential of scaffold materials in the improvement of sensing platforms and summarizes the progress in the application of novel scaffold-based materials as sensor, and discusses their advantages and limitations. Furthermore, the influence of the scaffold materials on the monitoring of infectious diseases such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and bacterial infections, was reviewed.

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Section: Scaffold-based Materials In Biosensing For Infectious Disease and Cancer Diagnosismentioning

confidence: 99%

Applications of scaffold-based advanced materials in biomedical sensing

Sarkhosh-Inanlou

Shafiei‐Irannejad

Azizi

et al. 2021

TrAC Trends in Analytical Chemistry

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“…Due to their superior photoactivities and conductivity, metallic sulfide nanomaterials have been used in various PEC biosensing systems to be photoactive materials or be one of other components through combining with photoactive materials [ 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Metallic Sulfide Nanomaterialsmentioning

confidence: 99%

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Wang

Jiang

et al. 2020

Sensors

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In recent years, sulfur-containing nanomaterials and their derivatives/composites have attracted much attention because of their important role in the field of biosensor, biolabeling, drug delivery and diagnostic imaging technology, which inspires us to compile this review. To focus on the relationships between advanced biomaterials and biosensors, this review describes the applications of various types of sulfur-containing nanomaterials in biosensors. We bring two types of sulfur-containing nanomaterials including metallic sulfide nanomaterials and sulfur-containing quantum dots, to discuss and summarize the possibility and application as biosensors based on the sulfur-containing nanomaterials. Finally, future perspective and challenges of biosensors based on sulfur-containing nanomaterials are briefly rendered.

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“…Our microaptasensors fuse the merits of microfabricated electrodes, electrochemical analysis, hybridization chain reaction (HCR)-based signal amplification, and multiple aptamers. In our protocol, long HCR products can attach multiple avidin-horseradish peroxidases (HRPs) for efficient signal amplification for the sensitive detection of exosomes in the sample [43][44][45][46] . In addition, by introducing anti-EpCAM aptamers, our micro-aptasensors enable the detection of EpCAM-positive exosomes with high specificity.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification

et al. 2021

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Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytical sensing methods struggle to achieve high sensitivity and high selectivity simultaneously. In this work, we present an electrochemical micro-aptasensor for the highly sensitive detection of exosomes by integrating a micropatterned electrochemical aptasensor and a hybridization chain reaction (HCR) signal amplification method. Specifically, exosomes are enriched on CD63 aptamer-functionalized electrodes and then recognized by HCR products with avidin-horseradish peroxidase (HRP) attached using EpCAM aptamers as bridges. Subsequently, the current signal that is generated through the enzyme reaction between the HRP enzyme and 3,3’,5,5’-tetramethylbenzidine (TMB)/H2O2 directly correlates to the amount of bound HRP on the HCR products and thus to the number of target exosomes. By introducing anti-EpCAM aptamers, micro-aptasensors can detect cancerous exosomes with high specificity. Due to the micropatterned electrodes and HCR dual-amplification strategy, the micro-aptasensors achieve a linear detection response for a wide range of exosome concentrations from 2.5×103 to 1×107 exosomes/mL, with a detection limit of 5×102 exosomes/mL. Moreover, our method successfully detects lung cancer exosomes in serum samples of early-stage and late-stage lung cancer patients, showcasing the great potential for early cancer diagnosis.

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CoOOH nanosheets-coated g-C3N4/CuInS2 nanohybrids for photoelectrochemical biosensor of carcinoembryonic antigen coupling hybridization chain reaction with etching reaction

Cited by 214 publications

References 48 publications

Applications of scaffold-based advanced materials in biomedical sensing

Applications of scaffold-based advanced materials in biomedical sensing

Biosensors Based on Advanced Sulfur-Containing Nanomaterials

Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification

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